Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: Initial findings in prostate cancer

Cancer Research

Volumn 61, Issue 1, 2001, Pages 110-117

  Degrado, Timothy R ^a   Coleman, R Edward ^a   Wang, Shuyan ^a   Baldwin, Steven W ^c   Orr, Matthew D ^c   Robertson, Cary N ^b   Polascik, Thomas J ^b   Price, David T ^b  

^a Departments of Radiology   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CHOLINE DERIVATIVE; FLUOROBROMOMETHANE; FLUORODEOXYGLUCOSE F 18; FLUOROMETHYLDIMETHYL 2 HYDROXYETHYLAMMONIUM; HEMICHOLINIUM 3; TRACER; UNCLASSIFIED DRUG; CHOLINE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE; FLUOROMETHYL DIMETHYL 2 HYDROXYETHYLAMMONIUM; FLUOROMETHYL DIMETHYL-2-HYDROXYETHYLAMMONIUM; QUATERNARY AMMONIUM DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ANIMAL CELL; ARTICLE; BONE METASTASIS; CANCER DIAGNOSIS; CANCER LOCALIZATION; CHOLINE UPTAKE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PHOSPHORYLATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE CARCINOMA; RADIOCHEMISTRY; RECEPTOR UPREGULATION; SOFT TISSUE TUMOR; SYNTHESIS; AGED; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG SCREENING; EVALUATION; ISOTOPE LABELING; METABOLISM; MIDDLE AGED; NUDE MOUSE; PROSTATE TUMOR; SCINTISCANNING; TISSUE DISTRIBUTION;

AGED; AGED, 80 AND OVER; ANIMALS; CHOLINE; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; HUMANS; ISOTOPE LABELING; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; PROSTATIC NEOPLASMS; QUATERNARY AMMONIUM COMPOUNDS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0034746341     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Relevance of positron emission tomography (PET) in oncology
2. Oncological applications of FDG PET imaging: Brain tumors, colorectal cancer, lymphoma, and melanoma
3. Positron emission tomography in urological oncology
4. PET imaging of brain tumor with [methyl-11C]choline
5. Brain tumors: Detection with C-11 choline PET
6. Locally increased uptake of fluorine-18-fluorodeoxyglucose after intracavitary administration of iodine-131-labeled antibody for primary brain tumors
7. PET imaging of prostate cancer using carbon-11-choline
8. Metastatic prostate cancer: Initial findings of PET with 2-deoxy-2-[F-18]-fluoro-D-glucose
9. Labeled choline and phosphoryl-choline: Body distribution and brain autoradiography: Concise communication
10. Carbon-11 choline: Synthesis, purification, and brain uptake inhibition by 2-dimethylaminoethanol
11. Automated synthesis of fluorine-18 labeled choline analogue: 2-fluoroethyl-dimethyl-2-oxyethylammonium
12. 18F]Fluorocholine (FCH) as an oncologic PET tracer: Evaluation in murine prostate cancer xenograft model
13. 2Br; fluoromethylation reagent with high specific radioactivity
14. 2BrF via aminopolyether supported nucleophilic substitution
15. A peltier thermal cycling unit for radiopharmaceutical synthesis
16. Choline kinase inhibitors as a novel approach for antiproliferative drug design
17. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
18. Epidermal growth factor-dependent activation of the src-family kinases
19. Heterotransplantation of human cradiopharyngiomas in athymic "nude" mice
20. Performance characteristics of a whole body PET scanner
21. 3H] and synthesis in vivo of acetylcholine in various tissues of guinea pigs
22. Studies of human tumors by MRS: A review
23. Analysis of cytosolic phosphoethanolamine and ethanolamine and their correlation with prognostic factors in breast cancer
24. Elevated phosphocholine concentration in ras-transformed NIH3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown
25. Early increase in choline kinase activity induction of the H-ras oncogene in mouse fibroblast cell lines
26. Increased choline kinase activity and elevated phosphocholine levels in human colon cancer
27. Prostate cancer: Localization with three-dimensional proton MR spectroscopic imaging-clinicopathologic study
28. Prostate cancer: Prediction of extracapsular extension with endorectal MR imaging and three-dimensional proton MR spectroscopic imaging
29. 1H magnetic resonance spectroscopy of the response of brain gliomas to radiotheraphy
30. Magnetic resonance spectroscopy guided brain tumor resection: Differentiation between recurrent glioma and radiation change in two diagnostically difficult cases
31. 14C)acetylcholine synthesis and (3H)choline high-affinity uptake in rat striatal synaptosomes
32. PDGF induction of tyrosine phosphorylation of GTPase activating protein
33. Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase-significance for diabetes and cancer
34. Uneven distribution of protein kinase C-α and -β isozymes in human sarcomas and carcinomas
35. Association between the PDGF receptor and members of the src family of tyrosine kinases
36. Phosphorylcholine: A novel second messenger essential for mitogenic activity of growth factors
37. The accuracy of CT in the staging of carcinoma of the prostate
38. Prostatic carcinoma: Staging by clinical assessment. CT and MR imaging
39. Comparison of magnetic resonance imaging and ultrasonography in staging early prostate cancer
40. Capromab pendetide. A review of its use as an imaging agent in prostate cancer
41. Metabolic imaging of untreated prostate cancer by positron emission tomography with 18-fluorine-labeled deoxyglucose
42. Possible role of FDG-PET in the evaluation of urologic malignancies
43. Monoclonal antibody imaging of occult prostate cancer in patients with elevated prostate-specific antigen. Positron emission tomography and biopsy correlation
44. Detection of bony metastases of androgen-dependent prostate cancer by PET-FDG
45. 1H-magnetic resonance spectroscopy
46. Immortalization and transformation are associated with specific alterations in choline metabolism