Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency

Aging Male

Volumn 7, Issue 2, 2004, Pages 133-143

  Genazzani, A R ^a   Inglese, S ^a   Lombardi, I ^a   Pieri, M ^a   Bernardi, F ^a   Genazzani, A D ^b   Rovati, L ^c   Luisi, M ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c Rotta Research Laboratorium   (Italy)

Author keywords

Age; DHEA; Male; Partial androgen deficiency of aging male (PADAM); Steroids

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ANDROSTANOLONE; ANDROSTENEDIONE; BETA ENDORPHIN; ESTRADIOL; ESTRONE; FOLLITROPIN; GROWTH HORMONE; HYDROCORTISONE; HYDROXYPROGESTERONE; LUTEINIZING HORMONE; PLACEBO; PRASTERONE; PRASTERONE SULFATE; PROGESTERONE; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN C; TESTOSTERONE;

ADULT; AGE; AGED; AGING; ARTHRALGIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; ENDOCRINE DISEASE; ENDOCRINE FUNCTION; ESTRADIOL BLOOD LEVEL; ESTRONE BLOOD LEVEL; FATIGUE; FOLLITROPIN BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; LONG TERM CARE; LOW DRUG DOSE; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MOOD; NEUROENDOCRINE SYSTEM; NEUROENDOCRINOLOGY; PARTIAL ANDROGEN DEFICIENCY; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; QUESTIONNAIRE; SCORING SYSTEM; SIDE EFFECT; SYMPTOM; TESTOSTERONE BLOOD LEVEL;

AGED; AGING; ANDROGENS; ANDROPAUSE; ARTHRALGIA; BETA-ENDORPHIN; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DEPRESSION; FATIGUE; GONADAL STEROID HORMONES; GONADOTROPINS, PITUITARY; HORMONE REPLACEMENT THERAPY; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED;

EID: 4644246248     PISSN: 13685538     EISSN: None     Source Type: Journal    
DOI: 10.1080/13685530412331284669     Document Type: Article

References (49)

1. Baulieu EE, Robel P. Neurosteroids: a new brain function. J Steroid Biochem Molec Biol 1990;37: 395-403
2. Corpechot C, Robel P, Axelson M, et al. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA 1981;78:4704-7
3. A receptor. Mechanism of action and physiological significance. Prog Neurobiol 1992;38:379-95
4. A receptor. Brain Res 1990;526:143-6
5. A receptor. Neuroscience 1991;45: 127-35
6. 3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors: J Endocrinol 1996;150:S33-42
7. Liut D, Dillon JS. Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha i2,3. J Biol Chem 2002;277: 21379-88
8. Simoncini T, Mannella P, Fornari L, et al. Dehydroepiandrosterone (DHEA) modulates endothelial nitric oxide synthesis via direct genomic and non-genomic mechanisms. Endocrinology 2003;144:3449-55
9. Labrie F, Belanger A, Cusan L, et al. Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology. J Clin Endocrinol Metabol 1997; 82: 2403-9
10. Field AE, Colditz GA, Willett WC, et al. The relation of smoking, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone binding globulin in middle-age. J Clin Endocrinol Metab 1994;79:1310-6
11. Salvini S, Stampfer MJ, Barbieri RL, et al. Effects of age, smoking and vitamins on plasma DHEAS levels: a cross-sectional study in men. J Clin Endocrinol Metab 1992;74:139-43
12. Sulcova J, Hill M, Hampl R, et al. Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects. J Endocrinol 1997;154:57-62
13. Labrie F, Belanger A, Cusan L, et al. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 1997;82:2396-402
14. Herbert J. The age of dehydroepiandrosterone. Lancet 1995;345:1193-4
15. Helzlsouer KJ, Gordon GB, Alberg A, et al. Relationship of prediagnostic serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing premenopausal breast cancer. Cancer Res 1992;52:1-4
16. Bulbrook RD, Hayward JL, Spicer CC. Relation between urinary androgen and corticoid excretion and subsequent breast cancer. Lancet 1977;2:395-8
17. Barrett-Connor E, Khaw K, Yen SSC. A prospective study of dehydroepiandrosterone sulfate mortality and cardiovascular disease. N Engl J Med 1986;315:1519-24
18. Feldman NA, Johannes CB, Araujo NB, et al. Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study. Am J Epidemiol 2001;153:79-89
19. Thoman ML, Weigle WD. The cellular and subcellular bases of immunosenescence. Adv Immunol 1989;46:221-61
20. Williams DP, Boyden TW, Parmenter RW, et al. Relationship of body fat percentage and fat distribution with dehydroepiandrosterone sulfate in premenstrual females. J Clin Endocrinol Metab 1993;77:80-5
21. Morales AJ, Nolan JJ, Nelson JC, et al. Effects of replacement dose of deydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994;78:1360-7
22. Hunt PJ, Gurnell EM, Hupper FA, et al. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000;85:4650-6
23. Spath-Schwalbe E, Dodt C, Dittmann J, et al. Dehydroepiandrosterone in Alzheimer disease. Lancet 1990;335:1412
24. Bernardi F, Lanzone A, Cento RM, et al. Allopregnanolone and dehydroepiandrosterone response to corticotropin-realising factor in patients suffering from Alzheimer disease and vascular dementia. Eur J Endocrinol 2000;138: 466-71
25. Roberts E, Bologa L, Flood JF, et al. Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice. Brain Res 1987;406:357-62
26. Kimonides VG, Khatibi NH, Svendsen CN, et al. Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) protect neurons against excitatory aminoacid induced neurotoxicity. Proc Natl Acad Sci USA 1999;95:1852-7
27. Kimonides VG, Spillantini MG, Sofroniew MV, et al. Dehydroepiandrosterone (DHEA) antagonises the neurotoxic effects of corticosterone and traslocation of SAPK3 in hippocampal primary cultures. Neuroscience 1999;89:429-36
28. May M, Holmes E, Rogers W, et al. Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone. Life Sci 1991;46: 1627-31
29. Nestler JE, Barlascini CO, Clore JN, et al. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensivity in normal men. J Clin Endocrinol Metab 1988;66:57-61
30. Vermeulen A. Andropause. Maturitas 2000;34: 5-15
31. Genazzani AR, Petraglia F, Mercuri N, et al. Effect of steroid hormones and antihormones on hypothalamic β-endorphin concentration in intact and castrated female rats. J Endocrinol Invest 1990; 13:91-6
32. Daughday WH, Mariz IK, Blethen SL. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites - a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol extracted serum. J Clin Endocrinol Metab 1980;51:781-5
33. Genazzani AR, Petraglia F, Bernardi F, et al. Circulating levels of allopregnanolone in human: gender, age and endocrine influences. J Clin Endocrinol Metab 1998;83:2099-103
34. Stomati M, Bersi C, Rubino S, et al. Neuroendocrine effects of different oestradiol-progestin regimens in postmenopausal women. Maturitas 1997;28:127-35
35. Legrain S, Massien C, Lahhlou N, et al. Dehydroepiandrosterone replacement administration and pharmacodynamic studies in healthy elderly subjects. J Clin Endocrinol Metab 2000;5: 3208-17
36. Kahn AJ, Halloran B. Dehydroepiandrosterone supplementation and bone turnover in middle-aged to elderly men. J Clin Endocrinol Metab 2002; 87:1544
37. Morales AJ, Haubrich RH, Hwang JY, et al. The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol 1998;49:421-32
38. Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci USA 2000;97:4279-84
39. Phillips GB. Relationship between serum dehydroepiandrosterone sulfate, androstenedione, and sex hormones in men and women. Eur J Endocrinol 1996;134:201-6
40. 5 derivatives in rat and monkey brain. J Steroid Biochem 1987;27: 649-55
41. Valenti G, Banchini A, Denti L, et al. Acute oral administration of dehydroepiandrosterone in male subjects: effects of age on bioavailability, sulfo-conjugation and bioconversion in other steroids. J Endocrinol Invest 1999;22:24-8
42. Artl W, Haas J, Cailles F, et al. Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens. J Clin Endocrinol Metab 1999;84:2170-6
43. Genazzani AD, Stomati MD, Strucchi C, et al. Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women. Fertil Steril 2001;76: 241-8
44. Genazzani AR, Facchinetti F, Pintor C, et al. Proopiomelanocortin-related peptide plasma levels throughout prepuberty and puberty. J Clin Endocrinol Metab 1983;57:56-61
45. Stomati M, Rubino S, Spinetti A, et al. Endocrine, neuroendocrine and behavioral effect of oral dehydroepiandrosterone supplementation in postmenopausal women. Gynecol Endocrinol 1999; 13:15-25
46. Cheng YJ, Karavolas HJ. Conversion of progesterone to 5α-pregnane-3,20-dione and 3α-hydroxy-5α-20-one by rat medial basal hypothalamus and the effects of estradiol and stage of estrus cycle on the conversion. Endocrinology 1973;93: 1157-62
47. Bernardi F, Pieri M, Stomati M, et al. Effects of different hormonal replacement therapies on circulating allopregnanolone and dehydroepiandrosterone levels in postmenopausal women. Gynecol Endocrinol 2003;17:65-77
48. Artl W, Callies F, Koheler I, et al. Dehydroepiandrosterone supplementation in healthy men with age-related decline of dehydroepiandrosterone secretion. J Clin Endocrinol Metab 2001;86: 4686-92
49. Percheron G, Hogrel JY, Denot-Ledunois S, et al. Effect of 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area. Arch Intern Med 2003;163:720-7