Research communication: Mitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic islets

Biochemical Journal

Volumn 353, Issue 2, 2001, Pages 175-180

  Ainscow, E K ^a   Rutter, G A ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Aequorin; ATP; Calcium; Luciferase; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; AEQUORIN; CALCIUM; LUCIFERASE; TOLBUTAMIDE; ANTIDIABETIC AGENT; GLUCOSE; INSULIN; POTASSIUM CHLORIDE;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM METABOLISM; GENE TARGETING; GLUCOSE OXIDATION; IMMUNOCYTOCHEMISTRY; INSULIN RELEASE; LONG TERM POTENTIATION; METABOLIC ACTIVATION; MITOCHONDRIAL MEMBRANE; NONHUMAN; PANCREAS ISLET CELL; POLYADENYLATION; PRIORITY JOURNAL; PROMOTER REGION; RAT; VIRUS EXPRESSION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CYTOMEGALOVIRUS; DRUG EFFECT; GENETICS; LUMINESCENCE; MALE; METABOLISM; MITOCHONDRION; PANCREAS ISLET; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; AEQUORIN; ANIMALS; CALCIUM; CELL LINE; CELLS, CULTURED; CYTOMEGALOVIRUS; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; LUCIFERASES; LUMINESCENT MEASUREMENTS; MALE; MITOCHONDRIA; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; TOLBUTAMIDE;

EID: 0035864148     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3530175     Document Type: Article

References (36)

1. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cell: Potential role in nutrient sensing
2. Metabolic fate of glucose in purified islet cells - Glucose-regulated anaplerosis in beta cells
3. The ABCs of ATP-sensitive potassium channels: More pieces of the puzzle
4. 2+ to supramicromolar levels in a pancreatic β-cell line: Possible role in glucose and agonist-induced insulin secretion
5. 2+ in aequorin-expressing INS-1 cells
6. 2+ oscillations in the pancreatic beta-cell line, MIN6
7. Role of calcium ions in regulation of mammalian intramitochondrial metabolism
8. 2+-binding to citrate cycle enzymes
9. 2+ with recombinant targeted aequorin: Significance for the regulation of pyruvate dehydrogenase activity
10. The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism
11. Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria
12. Glucose-induced ATP microdomains in single islet beta-cells
13. Integrating cytosolic calcium signals into mitochondrial metabolic responses
14. 2+ triggered, mitochondrial activation
15. 2+ revealed by specifically targeted recombinant aequorin
16. Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet beta cells
17. A simplified system for generating recombinant adenoviruses
18. Acute over-expression of LDH-A perturbs glucose stimulated mitochondrial metabolism and insulin secretion
19. Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 β-cells
20. Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera
21. 2+
22. A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling
23. Biphasic insulin release as the expression of combined inhibitory and potentiating effects of glucose
24. Cholinergic agonists prime the beta-cell to glucose stimulation
25. 2+ in the pancreatic β-cell
26. Pulsatile insulin secretion from isolated human pancreatic islets
27. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes
28. Decoding of cytosolic calcium oscillations in the mitochondria
29. Glucose-induced early changes in cytoplasmic calcium of pancreatic beta-cells studied with time-sharing dual-wavelength fluorometry
30. 2+ and the ATP/ADP ratio: A feedback control mechanism in mouse pancreatic istets
31. 2+) in single islets of Langerhans
32. 2+ or metabolism in normal mouse islets
33. Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells
34. Sur1 knockout mice - A model for K-ATP channel-independent regulation of insulin secretion
35. 2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell
36. Separation of the glucose-stimulated cytoplasmic mitochondrial NAD(P)H responses in pancreatic islet beta cells