Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2

Journal of Biological Chemistry

Volumn 273, Issue 6, 1998, Pages 3431-3437

  Furuta, Machi ^a,c   Carroll, Raymond ^a   Martin, Sean ^a   Swift, Hewson H ^a   Ravazzola, Mariella ^b   Orci, Lelio ^b   Steiner, Donald F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; CARBOXYPEPTIDASE H; FURIN; INSULIN; PROINSULIN; PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE DISRUPTION; GENE MUTATION; INSULIN RELEASE; INSULIN SYNTHESIS; MOUSE MUTANT; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN TARGETING; SECRETORY GRANULE;

AMINO ACID SEQUENCE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INSULIN; ISLETS OF LANGERHANS; KINETICS; MICE; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON; PROINSULIN; PROPROTEIN CONVERTASE 2; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE HOMOLOGY, AMINO ACID; SUBCELLULAR FRACTIONS; SUBTILISINS;

EID: 0032488981     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.6.3431     Document Type: Article

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