Characterization of Radioiodinated Ligand Binding to Amyloid β Plaques

Journal of Molecular Neuroscience

Volumn 20, Issue 3, 2003, Pages 249-253

  Kung, Mei Ping ^a   Zhuang, Zhi Ping ^a   Hou, Catherine ^a   Jin, Lee Way ^b   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

A ; aggregates; Radioiodinated ligands; SPECt imaging

Indexed keywords

2,3 DIHYDRO 1H IMIDAZO[1,2 B]PYRAZOLE; AMYLOID BETA PROTEIN; IODINE; LIGAND; MIPAFOX; THIOFLAVINE; TRACER; 2 (4' DIMETHYLAMINOPHENYL) 6 IODOBENZOTHIAZOLE; 2-(4'-DIMETHYLAMINOPHENYL)-6-IODOBENZOTHIAZOLE; 6 IODO 2 (4' DIMETHYLAMINO )PHENYL IMIDAZO(1,2 A)PYRIDINE; 6-IODO-2-(4'-DIMETHYLAMINO-)PHENYL-IMIDAZO(1,2-A)PYRIDINE; AMYLOID BETA PROTEIN[1-40]; DIAGNOSTIC AGENT; MIPA COMPOUND; PEPTIDE FRAGMENT; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; RADIOACTIVE IODINE; THIAZOLE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BINDING; DRUG UPTAKE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; IODINATION; LIGAND BINDING; MOUSE; NONHUMAN; PROTEIN BINDING; RADIOIODINATION; SENILE PLAQUE; STRUCTURE ANALYSIS; ALZHEIMER DISEASE; ANIMAL; BINDING COMPETITION; BINDING SITE; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; HUMANS; IODINE RADIOISOTOPES; LIGANDS; MALE; MICE; MICE, INBRED ICR; PEPTIDE FRAGMENTS; PYRAZOLES; PYRIDINES; SENILE PLAQUES; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0642341172     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:20:3:249     Document Type: Article

References (5)

1. Klunk W. E., Wang Y., Huang G.-F., Debnath M. L., Holt D. P., and Mathis C. A. (2001) Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci. 69, 1471-1484.
2. Kung M.-P., Hou C., Zhuang Z.-P., Zhang B., Skovronsky D. M., Trojanowski J. Q., et al. (2002) IMPY: an improved thioflavin-T derivative for in vivo labeling of β-amyloid plaques. Brain Res. 956, 202-210.
3. Kung M.-P., Skovronsky D., Hou C., Zhuang Z., Gur T., Zhang B., et al. (2003) Detection of amyloid plaques by radioligands for Aβ40 and Aβ42: potential imaging agents in Alzheimer's patients. J. Mol. Neurosci. 20, 15-24.
4. Zhuang Z.-P., Kung M.-P., Hou C., Plossel K., Skovronsky D., Gur T. L., et al. (2001a) IBOX(2-(4′-dimethyl-aminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain. Nucl. Med. Biol. 28, 887-894.
5. Zhuang Z.-P., Kung M.-P., Hou C., Skovronsky D., Gur T. L., Trojanowski J. Q., et al. (2001b) Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J. Med. Chem. 44, 1905-1914.