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Volumn 393, Issue 1, 2006, Pages 431-439

Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose

Author keywords

Glycolysis; Membrane potential; Mitochondria; Pyruvate; Reactive oxygen species; Uncoupling protein (UCP)

Indexed keywords

CELLS; CLONING; GLUCOSE; IONS; POLARIZATION; PROTONS;

EID: 30044432203     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050494     Document Type: Article
Times cited : (45)

References (52)
  • 1
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    • Ricquier, D. and Bouillaud, F. (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem. J. 345, 161-179
    • (2000) Biochem. J. , vol.345 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 2
    • 0033969421 scopus 로고    scopus 로고
    • Uncoupling protein 2 and 3 potential regulators of mitochondrial energy metabolism
    • Boss, O., Hagen, T. and Lowell, B. B. (2000) Uncoupling protein 2 and 3 potential regulators of mitochondrial energy metabolism. Diabetes 49, 143-156
    • (2000) Diabetes , vol.49 , pp. 143-156
    • Boss, O.1    Hagen, T.2    Lowell, B.B.3
  • 3
    • 0035283161 scopus 로고    scopus 로고
    • Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4
    • Bouillaud, F., Couplan, E., Pecqueur, C. and Ricquier, D. (2001) Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4. Biochim. Biophys. Acta 1504, 107-119
    • (2001) Biochim. Biophys. Acta , vol.1504 , pp. 107-119
    • Bouillaud, F.1    Couplan, E.2    Pecqueur, C.3    Ricquier, D.4
  • 4
    • 0033391964 scopus 로고    scopus 로고
    • A history of the first uncoupling protein, UCP1
    • Nicholls, D. G. and Rial, E. (1999) A history of the first uncoupling protein, UCP1. J. Bioenerg. Biomembr. 31, 399-406
    • (1999) J. Bioenerg. Biomembr. , vol.31 , pp. 399-406
    • Nicholls, D.G.1    Rial, E.2
  • 6
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon, B. and Nedergaard, J. (2004) Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 7
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls, D. G. and Locke, R. M. (1984) Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 1-64
    • (1984) Physiol. Rev. , vol.64 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 9
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
    • Gong, D. W., He, Y., Karas, M. and Reitman, M. (1997) Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin. J. Biol. Chem. 272, 24129-24132
    • (1997) J. Biol. Chem. , vol.272 , pp. 24129-24132
    • Gong, D.W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 10
    • 0033899544 scopus 로고    scopus 로고
    • Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation
    • Yu, X. X., Mao, W., Zhong, A., Schow, P., Brush, J., Sherwood, S. W., Adams, S. H. and Pan, G. (2000) Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB J. 14, 1611-1618
    • (2000) FASEB J. , vol.14 , pp. 1611-1618
    • Yu, X.X.1    Mao, W.2    Zhong, A.3    Schow, P.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 11
    • 0032545458 scopus 로고    scopus 로고
    • BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
    • Sanchis, D., Fleury, C., Chomiki, N., Goubern, M., Huang, Q., Neverova, M., Gregoire, F., Easlick, J., Raimbault, S., Levi-Meyrueis, C. et al. (1998) BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J. Biol. Chem. 273, 34611-34615
    • (1998) J. Biol. Chem. , vol.273 , pp. 34611-34615
    • Sanchis, D.1    Fleury, C.2    Chomiki, N.3    Goubern, M.4    Huang, Q.5    Neverova, M.6    Gregoire, F.7    Easlick, J.8    Raimbault, S.9    Levi-Meyrueis, C.10
  • 12
    • 0018358214 scopus 로고
    • Brown adipose tissue mitochondria
    • Nicholls, D. G. (1979) Brown adipose tissue mitochondria. Biochim. Biophys. Acta 549, 1-29
    • (1979) Biochim. Biophys. Acta , vol.549 , pp. 1-29
    • Nicholls, D.G.1
  • 14
    • 0020404134 scopus 로고
    • The acute regulation of mitochondrial proton conductance in cells and mitochondria from the brown fat of cold-adapted and warm-adapted guinea pigs
    • Locke, R. M., Rial, E. and Nicholls, D. G. (1982) The acute regulation of mitochondrial proton conductance in cells and mitochondria from the brown fat of cold-adapted and warm-adapted guinea pigs. Eur. J. Biochem 129, 381-387
    • (1982) Eur. J. Biochem , vol.129 , pp. 381-387
    • Locke, R.M.1    Rial, E.2    Nicholls, D.G.3
  • 18
    • 0032564864 scopus 로고    scopus 로고
    • Uncoupling: New approaches to an old problem of bioenergetics. Biochim
    • Skulachev, V. P. (1998) Uncoupling: new approaches to an old problem of bioenergetics. Biochim. Biophys. Acta 1363, 100-124
    • (1998) Biophys. Acta , vol.1363 , pp. 100-124
    • Skulachev, V.P.1
  • 21
    • 2242425423 scopus 로고    scopus 로고
    • Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
    • Brand, M. D., Pamplona, R., Portero-Otin, M., Requena, J. R., Roebuck, S. J., Buckingham, J. A., Clapnam, J. C. and Cadenas, S. (2002) Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. Biochem. J. 368, 597-603
    • (2002) Biochem. J. , vol.368 , pp. 597-603
    • Brand, M.D.1    Pamplona, R.2    Portero-Otin, M.3    Requena, J.R.4    Roebuck, S.J.5    Buckingham, J.A.6    Clapnam, J.C.7    Cadenas, S.8
  • 22
    • 0033387853 scopus 로고    scopus 로고
    • Anion carriers in fatty acid-mediated physiological uncoupling
    • Skulachev, V. P. (1999) Anion carriers in fatty acid-mediated physiological uncoupling. J. Bioenerg. Biomembr. 31, 431-445
    • (1999) J. Bioenerg. Biomembr. , vol.31 , pp. 431-445
    • Skulachev, V.P.1
  • 25
    • 1442349997 scopus 로고    scopus 로고
    • Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death
    • Vincent, A. M., Olzmann, J. A., Brownlee, M., Sivitz, W. I. and Russell, J. W. (2004) Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death. Diabetes 53, 726-734
    • (2004) Diabetes , vol.53 , pp. 726-734
    • Vincent, A.M.1    Olzmann, J.A.2    Brownlee, M.3    Sivitz, W.I.4    Russell, J.W.5
  • 26
    • 23944494249 scopus 로고    scopus 로고
    • Targeted expression of the human uncoupling protein 2 (hUCP2) to adults neurons extends life span in the fly
    • Fridell, Y., Sanchez-Blanco, A., Silvia, B. and Helfand, S. (2005) Targeted expression of the human uncoupling protein 2 (hUCP2) to adults neurons extends life span in the fly. Cell Metab. 1, 145-152
    • (2005) Cell Metab. , vol.1 , pp. 145-152
    • Fridell, Y.1    Sanchez-Blanco, A.2    Silvia, B.3    Helfand, S.4
  • 29
    • 0030761155 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells
    • Budd, S. L., Castilho, R. F. and Nicholls, D. G. (1997) Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells. FEBS lett. 415, 21-24
    • (1997) FEBS Lett. , vol.415 , pp. 21-24
    • Budd, S.L.1    Castilho, R.F.2    Nicholls, D.G.3
  • 33
    • 0035875366 scopus 로고    scopus 로고
    • A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast
    • Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B. and Brand, M. D. (2001) A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast. Biochem. J. 356, 779-789
    • (2001) Biochem. J. , vol.356 , pp. 779-789
    • Stuart, J.A.1    Harper, J.A.2    Brindle, K.M.3    Jekabsons, M.B.4    Brand, M.D.5
  • 34
    • 0025830873 scopus 로고
    • J-aggregate formation of a carbocyanine as a quanlitative fluorescent indicator of membrane potential
    • Reers, M., Smith, T. W. and Chen, L. B. (1991) J-aggregate formation of a carbocyanine as a quanlitative fluorescent indicator of membrane potential. Biochemistry 30, 4480-4486
    • (1991) Biochemistry , vol.30 , pp. 4480-4486
    • Reers, M.1    Smith, T.W.2    Chen, L.B.3
  • 35
    • 0037044809 scopus 로고    scopus 로고
    • High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their lib fiber content
    • Couplan, E., Gelly, C., Goubern, M., Fleury, C., Quesson, B., Silberberg, M., Thiaudiere, E., Mateo, P., Lonchampt, M., Levens, N. et al. (2002) High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their lib fiber content. J. Biol. Chem. 277, 43079-43088
    • (2002) J. Biol. Chem. , vol.277 , pp. 43079-43088
    • Couplan, E.1    Gelly, C.2    Goubern, M.3    Fleury, C.4    Quesson, B.5    Silberberg, M.6    Thiaudiere, E.7    Mateo, P.8    Lonchampt, M.9    Levens, N.10
  • 36
  • 38
    • 0030969868 scopus 로고    scopus 로고
    • Superoxide production by the mitochondrial respiratory chain
    • Turrens, J. F. (1997) Superoxide production by the mitochondrial respiratory chain. Biosci. Rep. 17, 3-8
    • (1997) Biosci. Rep. , vol.17 , pp. 3-8
    • Turrens, J.F.1
  • 41
    • 0038168520 scopus 로고    scopus 로고
    • Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10
    • Jaburek, M. and Garlid, K. D. (2003) Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10. J. Biol. Chem. 278, 25825-25831
    • (2003) J. Biol. Chem. , vol.278 , pp. 25825-25831
    • Jaburek, M.1    Garlid, K.D.2
  • 42
    • 0035282920 scopus 로고    scopus 로고
    • Uncoupling proteins: The issues from a biochemist point of view
    • Klingenberg, M. and Echtay, K. S. (2001) Uncoupling proteins: the issues from a biochemist point of view. Biochim. Biophys. Acta 1504, 128-143
    • (2001) Biochim. Biophys. Acta , vol.1504 , pp. 128-143
    • Klingenberg, M.1    Echtay, K.S.2
  • 44
    • 0037033039 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
    • Echtay, K. S., Murphy, M. P., Smith, R. A., Talbot, D. A. and Brand, M. D. (2002) Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J. Biol. Chem. 277, 47129-47135
    • (2002) J. Biol. Chem. , vol.277 , pp. 47129-47135
    • Echtay, K.S.1    Murphy, M.P.2    Smith, R.A.3    Talbot, D.A.4    Brand, M.D.5
  • 45
    • 0346814090 scopus 로고    scopus 로고
    • Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: Studies using a mitochondria- targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone
    • Murphy, M. P., Echtay, K. S., Blaikie, F. H., Asin-Cayuela, J., Cocheme, H. M., Green, K., Buckingham, J. A., Taylor, E. R., Hurrell, F., Hughes, G. et al. (2003) Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. J. Biol. Chem. 278, 48534-48545
    • (2003) J. Biol. Chem. , vol.278 , pp. 48534-48545
    • Murphy, M.P.1    Echtay, K.S.2    Blaikie, F.H.3    Asin-Cayuela, J.4    Cocheme, H.M.5    Green, K.6    Buckingham, J.A.7    Taylor, E.R.8    Hurrell, F.9    Hughes, G.10
  • 46
    • 0033542112 scopus 로고    scopus 로고
    • Cloning and characterization of the 5′ flanking region of the human uncoupling protein 3 (UCP3) gene
    • Acin, A., Rodriguez, M., Rique, H., Canet, E., Boutin, J. A. and Galizzi, J. P. (1999) Cloning and characterization of the 5′ flanking region of the human uncoupling protein 3 (UCP3) gene. Biochem. Biophys. Res. Commun. 258, 278-283
    • (1999) Biochem. Biophys. Res. Commun. , vol.258 , pp. 278-283
    • Acin, A.1    Rodriguez, M.2    Rique, H.3    Canet, E.4    Boutin, J.A.5    Galizzi, J.P.6
  • 49
    • 0025154843 scopus 로고
    • New substrates and competitive inhibitors of the Ch translocating pathway of the uncoupling protein of brown adipose tissue mitochondria
    • Jezek, P. and Garlid, K. D. (1990) New substrates and competitive inhibitors of the Ch translocating pathway of the uncoupling protein of brown adipose tissue mitochondria. J. Biol. Chem. 265, 19303-19311
    • (1990) J. Biol. Chem. , vol.265 , pp. 19303-19311
    • Jezek, P.1    Garlid, K.D.2
  • 50
    • 0015899581 scopus 로고
    • Brown-adipose-tissue mitochondria. The influence of albumin and nucleotides on passive ion permeabilities
    • Nicholls, D. G. and Lindberg, O. (1973) Brown-adipose-tissue mitochondria. The influence of albumin and nucleotides on passive ion permeabilities. Eur. J. Biochem. 37, 523-530
    • (1973) Eur. J. Biochem. , vol.37 , pp. 523-530
    • Nicholls, D.G.1    Lindberg, O.2
  • 51
    • 0031867963 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein may participate in futile cycling of pyruvate and other monocarboxylates
    • Jezek, P. and Borecky, J. (1998) Mitochondrial uncoupling protein may participate in futile cycling of pyruvate and other monocarboxylates. Am. J. Physiol. 275, C496-C504
    • (1998) Am. J. Physiol. , vol.275
    • Jezek, P.1    Borecky, J.2
  • 52
    • 10044268549 scopus 로고    scopus 로고
    • Mitochondrial activation and the pyruvate paradox in a human cell line
    • de Andrade, P. B., Casimir, M. and Maechler, P. (2004) Mitochondrial activation and the pyruvate paradox in a human cell line. FEBS lett. 578, 224-228
    • (2004) FEBS Lett. , vol.578 , pp. 224-228
    • De Andrade, P.B.1    Casimir, M.2    Maechler, P.3


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