Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo

Journal of Medicinal Chemistry

Volumn 49, Issue 26, 2006, Pages 7636-7645

  Henzing, Alexander J ^a   Dodson, Helen ^a   Reid, Joel M ^b   Kaufmann, Scott H ^b   Baxter, Robert L ^c   Earnshaw, William C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Mayo Clinic College of Medicine   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; AVIDIN; BIOTIN; CASPASE; CASPASE 6; CASPASE INHIBITOR; CYSTEINE PROTEINASE; CYTOKINE; LYSINE; MONOMER; N (2,4 DINITROPHENYL) 3 [N (N ALPHA BENZYLOXYCARBONYLGLUTAMYL)LYSYL]AMINO 5 (2,6 DIMETHYLBENZOYL) 4 OXOPENTANOIC ACID; PROCASPASE 6; PROTEOME; SEPHAROSE; UNCLASSIFIED DRUG;

AFFINITY LABELING; APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PURIFICATION;

AFFINITY LABELS; APOPTOSIS; CASPASE 6; CHROMATOGRAPHY, AFFINITY; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; ENZYME PRECURSORS; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; JURKAT CELLS; PROTEOME; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 33845923917     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060385h     Document Type: Article

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