Tumor dihydropyrimidine dehydrogenase expression is a useful marker in adjuvant therapy with oral fluoropyrimidines after curative resection of colorectal cancer

Cancer Chemotherapy and Pharmacology

Volumn 54, Issue 6, 2004, Pages 531-536

  Tsuji, Takashi ^a   Sawai, Terumitsu ^a   Takeshita, Hiroaki ^a   Nakagoe, Tohru ^a   Hidaka, Shigekazu ^a   Yamaguchi, Hiroyuki ^a   Yasutake, Toru ^a   Nagayasu, Takeshi ^a   Tagawa, Yutaka ^b  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

Colorectal cancer; Dihydropyrimidine dehydrogenase; Oral fluoropyrimidines

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADMINISTRATION, ORAL; CHEMOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; DIHYDROURACIL DEHYDROGENASE (NADP); DISEASE-FREE SURVIVAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUOROURACIL; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 11144303556     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0802-5     Document Type: Article

References (30)

1. Beck A, Etienne MC, Chéradame S, Fischel JL, Formento P, Renée N, Milano G (1994) A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil. Eur J Cancer 30A:1517
2. Borner MM, Schöffski P, Wit R, Caponigro F, Comella G, Sulkes A, Greim G, Peters GJ, Born K, Wanders J, Boer RF, Martin C, Fumoleau P (2002) Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomized crossover trial in advanced colorectal cancer. Eur J Cancer 38:349
3. Carmichael J, Popiela T, Radstone D, Falk S, Borner M, Oza A, Skovsgaard T, Munier S, Martin C (2002) Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 20:3617
4. Cox DR (1972) Regression models and life tables. J R Stat Soc 34:187
5. Diasio RB, Harris BE (1989) Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 16:215
6. Etienne MC, Chéradame S, Fischel JL, Formento P, Dassonville O, Renée N, Schneider M, Thyss A, Demard F, Milano G (1995) Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity. J Clin Oncol 13:1663
7. Etienne MC, Chatelut E, Pivot X, Lavit M, Pujol A, Canal P, Milano G (1998) Co-variables influencing 5-fluorouracil clearance during continuous venous infusion. A NONMEM analysis. Eur J Cancer 34:92
8. Etienne MC, Chazal M, Laurent-Puig P, Mangé N, Rosty C, Formento JL, Francoual M, Forment P, Renée N, Chamorey E, Bourgeon A, Seitz JF, Delpero JR, Letoublon C, Pezet D, Milano G (2002) Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses. J Clin Oncol 20:2832
9. Fleming ID, Cooper JS, Henson DE, Hunter RVP, Kennedy BJ, Murphy GP, O'Sullivan B, Sobin LH, Yarbro JW (1997) Colon and rectum. In: Fleming ID, Cooper JS, Henson DE, Hunter RPV, Kennedy BJ, Murphy GP, O'Sullivan B, Sobin LH, Yarbro JW (eds) AJCC cancer staging manual, 5th edn. Lippincott-Raven, New York, p 83
10. Hamilton SR, Vogelstein B, Kudo S, Riboli E, Nakamura S, Hainaut P, Rubio CA, Sobin LH, Fogt F, Winawer SJ, Goldgar DE, Jass JR (2000) Tumours of the colon and rectum. In: Hamilton SR, Aaltonen LA (eds) Pathology and genetics of tumours of the digestive system. International Agency for Research on Cancer, Lyon, p 103
11. Harris BE, Song R, Soong SJ, Diasio RB (1990) Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for arcadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 50:197
12. Ikenaka K, Shirasaka T, Kitano S, Fujii S (1979) Effect of uracil on metabolism of 5-fluorouracil in vitro. Gann 70:353
13. Ishikawa Y, Kubota T, Otani Y, Watanabe M, Teramoto T, Kumai K, Kitajima M, Takechi T, Okabe H, Fukushima M (1999) Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice. Clin Cancer Res 5:883
14. Japanese Society for Cancer of the Colon and Rectum (1997) Japanese classification of colorectal carcinoma, 1st English edn. Kanehara, Tokyo
15. Johnston SJ, Ridge SA, Cassidy J, McLeod HL (1999) Regulation of dihydropyrimidine dehydrogenase in colorectal cancer. Clin Cancer Res 5:2566
16. Kaplan EL, Meier P (1977) Nonparametric estimation from incomplete observation. J Am Stat Assoc 16:95
17. Kato T, Ohashi Y, Nakazato H, Koike A, Saji S, Suzuki H, Takagi H, Nimura Y, Hasumi A, Baba S, Manabe T, Maruta M, Miura K, Yamaguchi A (2002) Efficacy of oral UFT as adjuvant chemotherapy to curative resection of colorectal cancer: multicenter prospective randomized trial. Langenbecks Arch Surg 386:575
18. McLeod HL, Sludden J, Murray GI, Keenan RA, Davidson AI, Park K, Koruth M, Cassidy J (1998) Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours. Br J Cancer 77:461
19. Milano G, McLeod HL (2000) Can dihydropyrimidine dehydrogenase impact 5-fluorouracil-based treatment? Eur J Cancer 36:37
20. Mori K, Hasegawa M, Nishida M, Toma H, Fukuda M, Kubota T, Nagasue N, Yamana H, Chung KH, Ikeda T, Takasaki K, Oka M, Kameyama M, Toi M, Fujii H, Kitamura M, Murai M, Sasaki H, Ozono S, Makuuchi H, Shimada Y, Onishi Y, Aoyagi S, Mizutani K, Ogawa M, Nakao A, Kinoshita H, Tono T, Imamoto H, Nakashima Y, Manabe T (2000) Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissue. Int J Oncol 17:33
21. Morsman JM, Sludden J, Ameyaw MM, Githang'a J, Indalo A, Ofori-Adjei D, McLeod HL (2000) Evaluation of dihydropyrimidine dehydrogenase activity in South-west Asian, Kenyan and Ghanaian populations. Br J Clin Pharmacol 50:269
22. Peters GJ, van Groeningen CJ, Laurensse EJ, Pinedo HM (1991) A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer 68:1903
23. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer 35:1
24. Sakamoto J, Hamada C, Kodaira S, Nakazato H, Ohashi Y (1999) Adjuvant therapy with oral fluoropyrimidines as main chemotherapeutic agents after curative resection for colorectal cancer: individual patient data meta-analysis of randomized trials. Jpn J Clin Oncol 29:78
25. Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, Lenz HJ, Leichman CG, Leichman L, Diasio RB, Danenberg PV (2000) Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 6:1322
26. Smith RE, Lembersky BC, Wieand HS, Colangelo L, Mamounas EP (2000) UFT/leucovorin vs 5-FU/leucovorin in colon cancer. Oncology 14 [Suppl 9]:24
27. Takechi T, Uchida J, Fujioka A, Fukushima M (1997) Enhancing 5-fluorouracil cytotoxicity by inhibiting dihydropyrimidine dehydrogenase activity with uracil in human tumor cells. Int J Oncol 11:1041
28. Takenoue T, Kitayama J, Takei Y, Umetani N, Matsuda K, Nita ME, Hatano K, Tsuruo T, Nagawa H (2000) Characterization of dihydropyrimidine dehydrogenase on immunohistochemistry in colon carcinoma, and correlation between immunohistochemical score and protein level or messenger RNA expression. Ann Oncol 11:273
29. Tanaka-Nozaki M, Onda M, Tanaka N, Kato S (2001) Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels. Clin Cancer Res 7:2783
30. Yamashita K, Mikami Y, Ikeda M, Yamamura M, Kubozoe T, Urakami A, Yoshida K, Kimoto M, Tsunoda T (2002) Gender differences in the dihydropyrimidine dehydrogenase expression of colorectal cancers. Cancer Lett 188:231