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Volumn 155, Issue 5, 2006, Pages 645-653

RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology prize lecture

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN PATCHED; PROTEIN RET;

EID: 33845255290     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.02289     Document Type: Review
Times cited : (168)

References (91)
  • 1
    • 0022330363 scopus 로고
    • Activation of a novel human transforming gene, ret, by DNA rearrangement
    • Takahashi M, Ritz J & Cooper GM. Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 1985 42 581-588.
    • (1985) Cell , vol.42 , pp. 581-588
    • Takahashi, M.1    Ritz, J.2    Cooper, G.M.3
  • 2
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • Airaksinen MS & Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nature Reviews Neuroscience 2002 3 383-394.
    • (2002) Nature Reviews Neuroscience , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 3
    • 18344380647 scopus 로고    scopus 로고
    • Molecular genetics of multiple endocrine neoplasia types 1 and 2
    • Marx SJ. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nature Reviews. Cancer 2005 5 367-375.
    • (2005) Nature Reviews Cancer , vol.5 , pp. 367-375
    • Marx, S.J.1
  • 7
    • 30144437331 scopus 로고    scopus 로고
    • Oncogenic rearrangements of the NTRK1/NGF receptor
    • Pierotti MA & Greco A. Oncogenic rearrangements of the NTRK1/NGF receptor. Cancer Letters 2006 232 90-98.
    • (2006) Cancer Letters , vol.232 , pp. 90-98
    • Pierotti, M.A.1    Greco, A.2
  • 8
    • 0035516099 scopus 로고    scopus 로고
    • RET oncogene activation in papillary thyroid carcinoma
    • Tallini G & Asa SL. RET oncogene activation in papillary thyroid carcinoma. Advances in Anatomic Pathology 2001 8 345-354.
    • (2001) Advances in Anatomic Pathology , vol.8 , pp. 345-354
    • Tallini, G.1    Asa, S.L.2
  • 9
    • 0035986363 scopus 로고    scopus 로고
    • RET/PTC rearrangement in thyroid tumors
    • Nikiforov YE. RET/PTC rearrangement in thyroid tumors. Endocrine Pathology 2002 13 3-16.
    • (2002) Endocrine Pathology , vol.13 , pp. 3-16
    • Nikiforov, Y.E.1
  • 10
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • Kondo T, Ezzat S & Asa SL. Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nature Reviews Cancer 2006 6 292-306.
    • (2006) Nature Reviews Cancer , vol.6 , pp. 292-306
    • Kondo, T.1    Ezzat, S.2    Asa, S.L.3
  • 11
    • 33646506360 scopus 로고    scopus 로고
    • Drug insight: Small-molecule inhibitors of protein kinases in the treatment of thyroid cancer
    • Santoro M & Carlomagno F. Drug insight: small-molecule inhibitors of protein kinases in the treatment of thyroid cancer. Nature Clinical Practice. Endocrinology and Metabolism 2006 2 42-52.
    • (2006) Nature Clinical Practice. Endocrinology and Metabolism , vol.2 , pp. 42-52
    • Santoro, M.1    Carlomagno, F.2
  • 12
    • 33748742902 scopus 로고    scopus 로고
    • Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: Effects of the detection methods and genetic heterogeneity
    • Zhu Z, Ciampi R, Nikiforova MN, Gandhi M & Nikiforov YE. Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity. Journal of Clinical Endocrinology and Metabolism 2006 91 3603-3610.
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , pp. 3603-3610
    • Zhu, Z.1    Ciampi, R.2    Nikiforova, M.N.3    Gandhi, M.4    Nikiforov, Y.E.5
  • 22
    • 0030941779 scopus 로고    scopus 로고
    • Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children
    • Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H & Fagin JA. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Research 1997 57 1690-1694.
    • (1997) Cancer Research , vol.57 , pp. 1690-1694
    • Nikiforov, Y.E.1    Rowland, J.M.2    Bove, K.E.3    Monforte-Munoz, H.4    Fagin, J.A.5
  • 23
    • 13444311710 scopus 로고    scopus 로고
    • Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomas
    • Nikiforov YE. Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomas. Endocrine Pathology 2004 15 319-327.
    • (2004) Endocrine Pathology , vol.15 , pp. 319-327
    • Nikiforov, Y.E.1
  • 24
    • 0031931662 scopus 로고    scopus 로고
    • RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: Correlation with clinicopathological features
    • Bongarzone I, Vigneri P, Mariani L, Collini P, Pilotti S & Pierotti MA. RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features. Clinical Cancer Research 1998 4 223-228.
    • (1998) Clinical Cancer Research , vol.4 , pp. 223-228
    • Bongarzone, I.1    Vigneri, P.2    Mariani, L.3    Collini, P.4    Pilotti, S.5    Pierotti, M.A.6
  • 26
    • 0031780414 scopus 로고    scopus 로고
    • Sporadic ret-rearranged papillary carcinoma of the thyroid: A subset of slow growing, less aggressive thyroid neoplasms?
    • Soares P, Fonseca E, Wynford-Thomas D & Sobrinho-Simoes M. Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms? Journal of Pathology 1998 185 71-78.
    • (1998) Journal of Pathology , vol.185 , pp. 71-78
    • Soares, P.1    Fonseca, E.2    Wynford-Thomas, D.3    Sobrinho-Simoes, M.4
  • 27
    • 0031933680 scopus 로고    scopus 로고
    • RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes
    • Tallini G, Santoro M, Helie M, Carlomagno F, Salvatore G, Chiappetta G, Carcangiu ML & Fusco A. RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes. Clinical Cancer Research 1998 4 287-294.
    • (1998) Clinical Cancer Research , vol.4 , pp. 287-294
    • Tallini, G.1    Santoro, M.2    Helie, M.3    Carlomagno, F.4    Salvatore, G.5    Chiappetta, G.6    Carcangiu, M.L.7    Fusco, A.8
  • 29
    • 0033874066 scopus 로고    scopus 로고
    • Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas
    • La Perle KM, Jhiang SM & Capen CC. Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas. American Journal of Pathology 2000 157 671-677.
    • (2000) American Journal of Pathology , vol.157 , pp. 671-677
    • La Perle, K.M.1    Jhiang, S.M.2    Capen, C.C.3
  • 31
    • 0030881411 scopus 로고    scopus 로고
    • Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis
    • Mizuno T, Kyoizumi S, Suzuki T, Iwamoto KS & Seyama T. Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis. Oncogene 1997 15 1455-1460.
    • (1997) Oncogene , vol.15 , pp. 1455-1460
    • Mizuno, T.1    Kyoizumi, S.2    Suzuki, T.3    Iwamoto, K.S.4    Seyama, T.5
  • 33
    • 0030929178 scopus 로고    scopus 로고
    • High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation
    • Bounacer A, Wicker R, Caillou B, Cailleux AF, Sarasin A, Schlumberger M & Suarez HG. High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation. Oncogene 1997 15 1263-1273.
    • (1997) Oncogene , vol.15 , pp. 1263-1273
    • Bounacer, A.1    Wicker, R.2    Caillou, B.3    Cailleux, A.F.4    Sarasin, A.5    Schlumberger, M.6    Suarez, H.G.7
  • 35
    • 0033619482 scopus 로고    scopus 로고
    • Ret protooncogene rearrangement in thyroid cancer around Semipalatinsk nuclear testing site
    • Alipov G, Ito M, Prouglo, Y, Takamura N & Yamashita S. Ret protooncogene rearrangement in thyroid cancer around Semipalatinsk nuclear testing site. Lancet 1999 354 1528-1529.
    • (1999) Lancet , vol.354 , pp. 1528-1529
    • Alipov, G.1    Ito, M.2    Prouglo, Y.3    Takamura, N.4    Yamashita, S.5
  • 36
    • 0036632771 scopus 로고    scopus 로고
    • Cancer after nuclear fallout: Lessons from the Chernobyl accident
    • Williams D. Cancer after nuclear fallout: lessons from the Chernobyl accident. Nature Reviews Cancer 2002 2 543-549.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 543-549
    • Williams, D.1
  • 38
    • 0034016275 scopus 로고    scopus 로고
    • Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: Biological, phenotypic, and clinical implications
    • Rabes HM, Demidchik EP, Sidorow JD, Lengfelder E, Beimfohr C, Hoelzel D & Klugbauer S. Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. Clinical Cancer Research 2000 6 1093-1103.
    • (2000) Clinical Cancer Research , vol.6 , pp. 1093-1103
    • Rabes, H.M.1    Demidchik, E.P.2    Sidorow, J.D.3    Lengfelder, E.4    Beimfohr, C.5    Hoelzel, D.6    Klugbauer, S.7
  • 40
  • 42
    • 17144394374 scopus 로고    scopus 로고
    • Frequency of BRAF T1796A mutation in papillary thyroid carcinoma relates to age of patient at diagnosis and not to radiation exposure
    • Powell N, Jeremiah S, Morishita M, Dudley E, Bethel J, Bogdanova T, Tronko M & Thomas G. Frequency of BRAF T1796A mutation in papillary thyroid carcinoma relates to age of patient at diagnosis and not to radiation exposure. Journal of Pathology 2005 205 558-564.
    • (2005) Journal of Pathology , vol.205 , pp. 558-564
    • Powell, N.1    Jeremiah, S.2    Morishita, M.3    Dudley, E.4    Bethel, J.5    Bogdanova, T.6    Tronko, M.7    Thomas, G.8
  • 45
  • 46
    • 33646126725 scopus 로고    scopus 로고
    • Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements
    • Gandhi M, Medvedovic M, Stringer JR & Nikiforov YE. Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements. Oncogene 2006 25 2360-2366.
    • (2006) Oncogene , vol.25 , pp. 2360-2366
    • Gandhi, M.1    Medvedovic, M.2    Stringer, J.R.3    Nikiforov, Y.E.4
  • 49
    • 0038648323 scopus 로고    scopus 로고
    • Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels
    • Wang J, Knauf JA, Basu S, Puxeddu E, Kuroda H, Santoro M, Fusco A & Fagin JA. Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels. Molecular Endocrinology 2003 17 1425-1436.
    • (2003) Molecular Endocrinology , vol.17 , pp. 1425-1436
    • Wang, J.1    Knauf, J.A.2    Basu, S.3    Puxeddu, E.4    Kuroda, H.5    Santoro, M.6    Fusco, A.7    Fagin, J.A.8
  • 50
    • 0042303810 scopus 로고    scopus 로고
    • RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase
    • Knauf JA, Kuroda H, Basu S & Fagin JA. RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase. Oncogene 2003 22 4406-4412.
    • (2003) Oncogene , vol.22 , pp. 4406-4412
    • Knauf, J.A.1    Kuroda, H.2    Basu, S.3    Fagin, J.A.4
  • 57
    • 0942290418 scopus 로고    scopus 로고
    • H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: Functional characterization
    • Celetti A, Cerrato A, Merolla F, Vitagliano D, Vecchio G & Grieco M. H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization. Oncogene 2004 23 109-121.
    • (2004) Oncogene , vol.23 , pp. 109-121
    • Celetti, A.1    Cerrato, A.2    Merolla, F.3    Vitagliano, D.4    Vecchio, G.5    Grieco, M.6
  • 61
    • 0030988478 scopus 로고
    • Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity
    • Tong Q, Xing S & Jhiang SM. Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity. Journal of Biological Chemistry 1993 272 9043-9047.
    • (1993) Journal of Biological Chemistry , vol.272 , pp. 9043-9047
    • Tong, Q.1    Xing, S.2    Jhiang, S.M.3
  • 62
  • 63
    • 0031924319 scopus 로고    scopus 로고
    • Shc and Enigma are both required for mitogenic signaling by Ret/ptc2
    • Durick K, Gill GN & Taylor SS. Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Molecular and Cellular Biology 1998 18 2298-2308.
    • (1998) Molecular and Cellular Biology , vol.18 , pp. 2298-2308
    • Durick, K.1    Gill, G.N.2    Taylor, S.S.3
  • 64
    • 0034967978 scopus 로고    scopus 로고
    • Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade
    • Melillo RM, Santoro M, Ong SH, Billaud M, Fusco A, Hadari YR, Schlessinger J & Lax I. Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Molecular and Cellular Biology 2001 21 4177-4187.
    • (2001) Molecular and Cellular Biology , vol.21 , pp. 4177-4187
    • Melillo, R.M.1    Santoro, M.2    Ong, S.H.3    Billaud, M.4    Fusco, A.5    Hadari, Y.R.6    Schlessinger, J.7    Lax, I.8
  • 65
    • 9444247656 scopus 로고    scopus 로고
    • Minireview: PRKAR1A: Normal and abnormal functions
    • Bossis I & Stratakis CA. Minireview: PRKAR1A: normal and abnormal functions. Endocrinology 2004 145 5452-5458.
    • (2004) Endocrinology , vol.145 , pp. 5452-5458
    • Bossis, I.1    Stratakis, C.A.2
  • 67
    • 17044365440 scopus 로고    scopus 로고
    • Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
    • Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M & Piccolo S. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 2005 121 87-99.
    • (2005) Cell , vol.121 , pp. 87-99
    • Dupont, S.1    Zacchigna, L.2    Cordenonsi, M.3    Soligo, S.4    Adorno, M.5    Rugge, M.6    Piccolo, S.7
  • 68
    • 0029951486 scopus 로고    scopus 로고
    • Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells
    • Yeh S & Chang C. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. PNAS 1996 93 5517-5521.
    • (1996) PNAS , vol.93 , pp. 5517-5521
    • Yeh, S.1    Chang, C.2
  • 69
    • 0033523021 scopus 로고    scopus 로고
    • Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma
    • Heinlein CA, Ting HJ, Yeh S & Chang C. Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. Journal of Biological Chemistry 1999 274 16147-16152.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 16147-16152
    • Heinlein, C.A.1    Ting, H.J.2    Yeh, S.3    Chang, C.4
  • 70
  • 73
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M. BRAF mutation in thyroid cancer. Endocrine-Related Cancer 2005 12 245-262.
    • (2005) Endocrine-Related Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 74
    • 4544246997 scopus 로고    scopus 로고
    • Challenging dogma in thyroid cancer molecular genetics-role of RET/PTC and BRAF in tumor initiation
    • Fagin JA. Challenging dogma in thyroid cancer molecular genetics-role of RET/PTC and BRAF in tumor initiation. Journal of Clinical Endocrinology and Metabolism 2004 89 4264-4266.
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 4264-4266
    • Fagin, J.A.1
  • 76
    • 30944445020 scopus 로고    scopus 로고
    • BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: Functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis
    • Mitsutake N, Miyagishi M, Mitsutake S, Akeno N, Mesa C, Jr, Knauf JA, Zhang L, Taira K & Fagin JA. BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology 2006 147 1014-1019.
    • (2006) Endocrinology , vol.147 , pp. 1014-1019
    • Mitsutake, N.1    Miyagishi, M.2    Mitsutake, S.3    Akeno, N.4    Mesa Jr., C.5    Knauf, J.A.6    Zhang, L.7    Taira, K.8    Fagin, J.A.9
  • 78
    • 33746166501 scopus 로고    scopus 로고
    • Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling
    • Mesa C Jr, Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, Knauf JA, Weber GF & Fagin JA. Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling. Cancer Research 2006 66 6521-6529.
    • (2006) Cancer Research , vol.66 , pp. 6521-6529
    • Mesa Jr., C.1    Mirza, M.2    Mitsutake, N.3    Sartor, M.4    Medvedovic, M.5    Tomlinson, C.6    Knauf, J.A.7    Weber, G.F.8    Fagin, J.A.9
  • 79
    • 10344258041 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase cascade to treat cancer
    • Sebolt-Leopold JS & Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nature Reviews Cancer 2004 4 937-947.
    • (2004) Nature Reviews Cancer , vol.4 , pp. 937-947
    • Sebolt-Leopold, J.S.1    Herrera, R.2
  • 80
    • 33645213890 scopus 로고    scopus 로고
    • Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints
    • Knauf JA, Ouyang B, Knudsen ES, Fukasawa K, Babcock G & Fagin JA. Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints. Journal of Biological Chemistry 2006 281 3800-3809.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 3800-3809
    • Knauf, J.A.1    Ouyang, B.2    Knudsen, E.S.3    Fukasawa, K.4    Babcock, G.5    Fagin, J.A.6
  • 81
    • 20144372793 scopus 로고    scopus 로고
    • Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    • Knauf JA, Ma X, Smith EP, Zhang L, Mitsutake N, Liao XH, Refetoff S, Nikiforov YE & Fagin JA. Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Research 2005 65 4238-4245.
    • (2005) Cancer Research , vol.65 , pp. 4238-4245
    • Knauf, J.A.1    Ma, X.2    Smith, E.P.3    Zhang, L.4    Mitsutake, N.5    Liao, X.H.6    Refetoff, S.7    Nikiforov, Y.E.8    Fagin, J.A.9
  • 84
    • 0043170839 scopus 로고    scopus 로고
    • Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors
    • Russell JP, Shinohara S, Melillo RM, Castallone MD, Santoro M & Rothstein JL. Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors. Oncogene 2003 22 4569-4577.
    • (2003) Oncogene , vol.22 , pp. 4569-4577
    • Russell, J.P.1    Shinohara, S.2    Melillo, R.M.3    Castallone, M.D.4    Santoro, M.5    Rothstein, J.L.6
  • 90
    • 1642320337 scopus 로고    scopus 로고
    • Proinflammatory mediators and genetic background in oncogene mediated tumor progression
    • Russell JP, Engiles JB & Rothstein JL. Proinflammatory mediators and genetic background in oncogene mediated tumor progression. Journal of Immunology 2004 172 4059-4067.
    • (2004) Journal of Immunology , vol.172 , pp. 4059-4067
    • Russell, J.P.1    Engiles, J.B.2    Rothstein, J.L.3
  • 91
    • 33645698808 scopus 로고    scopus 로고
    • Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo
    • Ouyang B, Knauf JA, Smith EP, Zhang L, Ramsey T, Yusuff N, Batt D & Fagin JA. Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo. Clinical Cancer Research 2006 12 1785-1793.
    • (2006) Clinical Cancer Research , vol.12 , pp. 1785-1793
    • Ouyang, B.1    Knauf, J.A.2    Smith, E.P.3    Zhang, L.4    Ramsey, T.5    Yusuff, N.6    Batt, D.7    Fagin, J.A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.