RET/PTC activation in hyalinizing trabecular tumors of the thyroid

American Journal of Surgical Pathology

Volumn 24, Issue 12, 2000, Pages 1615-1621

  Papotti, Mauro ^a   Volante, Marco ^a   Giuliano, Ada ^c   Fassina, Ambrogio ^b   Fusco, Alfredo ^e   Bussolati, Gianni ^a   Santoro, Massimo ^d   Chiappetta, Gennaro ^c  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Hyalinizing trabecular tumor; Immunohistochemistry; Papillary carcinoma; RET PTC; RT PCR; Thyroid

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; GENE REARRANGEMENT; GENETIC TRANSFECTION; HISTOGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ONCOGENE; PAPILLARY CARCINOMA; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID TUMOR;

ADENOMA; ADULT; AGED; CARCINOMA, PAPILLARY; CHILD; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; PROTO-ONCOGENES; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYROID NEOPLASMS;

EID: 0033660519     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200012000-00004     Document Type: Article

References (48)

1. GDNF family neurotrophic factor signaling: Four masters, one servant?
2. RET proto-oncogene rearrangement in thyroid cancer around Semipalatinsk nuclear testing site
3. Frequent activation of RET protooncogene by fusion with a new activating gene in papillary thyroid carcinomas
4. Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of RET tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A
5. High prevalence of activating RET proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation
6. Poorly differentiated (insular) thyroid carcinoma. A reinterpretation of Langhans' 'wuchernde struma.'
7. Hyalinizing trabecular adenoma of the thyroid gland
8. Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation
9. Expression of stratified epithelial type cytokeratins in hyalinizing trabecular adenoma supports their relationship with papillary carcinoma of the thyroid
10. Molecular and biochemical analysis of RET/PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer
11. Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident
12. Hyalinizing trabecular carcinoma of the thyroid gland: Report of two cases of follicular cell thyroid carcinoma with hyalinizing trabecular patterns
13. PTC is a novel rearranged form of the RET proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinoma
14. Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident
15. Detection of the PTC/retTPC oncogene in human thyroid cancers
16. Targeted expression of the RET/PTC1 oncogene induces papillary thyroid carcinomas
17. Hyalinizing trabecular adenoma of the thyroid. A report of three cases
18. Accumulated basal membrane material in hyalinizing trabecular tumors of the thyroid
19. Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chemobyl and analysis of the involved RET-fused gene RFG5
20. High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident
21. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas
22. Thyroid paraganglioma: A clinicopathological and immunohistochemical study of three cases
23. RET oncogene activation in papillary thyroid carcinoma: Prevalence and implications on the histological parameters
24. Abnormal intracellular and extracellular distribution of basement membrane material in papillary carcinoma and hyalinizing trabecular tumors of the thyroid
25. Hyalinizing trabecular adenoma of the thyroid: Morphology and differential diagnosis
26. Hyalinizing trabecular carcinoma of the thyroid gland
27. Distinct patterns of RET rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children
28. Expression of the c-ret protooncogene during mouse embryogenesis
29. Poorly differentiated thyroid carcinoma with primordial cell component
30. Immunophenotypic heterogeneity of hyalinizing trabecular tumor of the thyroid
31. Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells
32. The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids
33. Hyalinizing trabecular adenoma of the thyroid gland
34. Hyalinizing trabecular adenoma: A misnomer for a peculiar tumor of the thyroid gland
35. RET oncogene activation in human thyroid neoplasms is restricted to the papillary carcinoma subtype
36. Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice
37. Molecular characterisation of RET/PTC3: A novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma
38. The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line
39. Distinct frequency of RET rearrangements in papillary thyroid carcinoma of children and adults from Belarus
40. Sporadic rearranged papillary carcinoma of the thyroid: A subset of slow growing, less aggressive thyroid neoplasms?
41. Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia
42. RT/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes
43. High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: A strong correlation between RET/PTC3 and the solid-follicular variant
44. Leucine zipper-mediated dimerization is essential for the PTC1 oncogene activity
45. RET/PTC oncogene activation is an early event in thyroid carcinogenesis
46. How cancer arises
47. Low rate of ret proto-oncogene activation (PTC/retTPC) in papillary thyroid carcinomas from Saudi Arabia