Shc and enigma are both required for mitogenic signaling by Ret/ptc2

Molecular and Cellular Biology

Volumn 18, Issue 4, 1998, Pages 2298-2308

  Durick, Kyle ^a   Gill, Gordon N ^a   Taylor, Susan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; ONCOPROTEIN; TYROSINE; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MALIGNANT TRANSFORMATION; MITOGENESIS; MOUSE; MULTIPLE ENDOCRINE NEOPLASIA; NONHUMAN; ONCOGENE; ONCOGENE RET; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; THYROID PAPILLARY CARCINOMA;

ANIMALIA;

EID: 0031924319     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.4.2298     Document Type: Article

References (58)

1. Asai, N., H. Murakami, T. Iwashita, and M. Takahashi. 1996. A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with She adaptor proteins. J. Biol. Chem. 271:17644-17649.
2. Attie, T., A. Pelet, P. Sarda, P. Edery, C. Eng, L. M. Mulligan, B. A. J. Ponder, A. Munnich, and S. Lyonnet. 1994. A 7bp deletion of the RET proto-oncogene mutations in familial Hirschsprung's disease. Hum. Mol. Genet. 3:1439-1440.
3. Ausubel, F., R. Brent, R. Kingston, D. Moore, J. Seidman, J. Smith, and K. Struhl (ed.). 1994. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
4. Bongarzone, I., M. G. Butti, S. Coronelli, M. G. Borrello, M. Santoro, P. Mondellini, S. Pilotti, A. Fusco, G. Della Porta, and M. A. Pierotti. 1994. Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. Cancer Res. 54:2979-2985.
5. Bongarzone, I., N. Monzini, M. G. Borrello, C. Carcano, G. Ferraresi, E. Arighi, P. Mondellini, G. Della Porta, and M. A. Pierotti. 1993. Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RIα of cyclic AMP-dependent protein kinase A. Mol. Cell. Biol. 13:358-366.
6. Borrello, M. G., L. Alberti, E. Arighi, I. Bongarzone, C. Battistini, A. Bardelli, B. Pasini, C. Piutti, M. G. Rizzetti, P. Mondellini, M. T. Radice, and M. A. Pierotti. 1996. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cγ. Mol. Cell. Biol. 16:2151-2163.
7. Buj-Bello, A., J. Adu, L. G. Pinon, A. Horton, J. Thompson, A. Rosenthal, M. Chinchetru, V. L. Buchman, and A. M. Davies. 1997. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 387:721-724.
8. Cai, H., J. Szeberenyi, and G. M. Cooper. 1990. Effect of a dominant inhibitory HA-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol. Cell. Biol. 10:5314-5323.
9. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745-2752.
10. src myristylation and membrane association and for cell transformation. Mol. Cell. Biol. 4:1834-1842.
11. Dong, H., R. J. O'Brien, E. T. Fung, A. A. Lanahan, P. F. Worley, and R. L. Huganir. 1997. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386:279-284.
12. Durbec, P., C. V. Marcos-Gutierrez, C. Kilkenny, M. Grigoriou, K. Wartiowaara, P. Suvanto, D. Smith, B. Ponder, F. Costantini, M. Saarma, S. Hannu, and V. Pachnis. 1996. GDNF signalling through the Ret receptor tyrosine kinase. Nature 381:789-793.
13. Durick, K., R. Y. Wu, G. N. Gill, and S. S. Taylor. 1996. Mitogenic signaling by Ret/ptc2 requires association with Enigma via a LIM domain. J. Biol. Chem. 271:12691-12694.
14. Durick, K., V. J. Yao, M. G. Borrello, I. Bongarzone, M. A. Pierotti, and S. S. Taylor. 1995. Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2. J. Biol. Chem 270:24642-24645.
15. Edery, P., S. Lyonnet, L. M. Mulligan, A. Pelet, E. Dow, L. Abel, S. Holder, C. Nihoul-Fekete, B. A. Ponder, and A. Munnich. 1994. Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature 367:378-380.
16. Egan, S. E., B. W. Giddings, M. W. Brooks, L. Buday, A. M. Sizeland, and R. A. Weinberg. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363:45-51.
17. Feig, L. A., and G. M. Cooper. 1988. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8:3235-3243.
18. Grieco, M., M. Santoro, M. T. Berlingieri, R. M. Melillo, R. Donghi, I. Bongarzone, M. A. Pierotti, G. Della Porta, A. Fusco, and G. Vecchio. 1990. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60:557-563.
19. Gustafson, T. A., W. He, A. Craparo, C. D. Schaub, and T. J. O'Neill. 1995. Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15:2500-2508.
20. Harrison, S. C. 1996. Peptide-surface association: the case of PDZ and PTB domains. Cell 86:341-343.
21. Henderson, C. E., H. S. Phillips, R. A. Pollock, A. M. Davies, C. Lemeulle, M. Armanini, L. C. Simpson, B. Moffet, R. A. Vandlen, V. E. Koliatsos, and A. Rosenthal. 1994. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266:1062-1064.
22. Huang, L. J., K. Durick, J. A. Weiner, J. Chun, and S. S. Taylor. 1997. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J. Biol. Chem. 272:8057-8064.
23. Jhiang, S. M., J. E. Sagartz, Q. Tong, J. Parker-Thornburg, C. C. Capen, J. Y. Cho, S. Xing, and C. Ledent. 1996. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology 137:375-378.
24. Jing, S., D. Wen, Y. Yu, P. L. Hoist, Y. Luo, M. Fang, R. Tamir, L. Antonio, Z. Hu, R. Cupples, J. Louis, S. Hu, B. W. Altrock, and G. M. Fox. 1996. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF. Cell 85:1113-1124.
25. Kamps, M. P., J. E. Buss, and B. M. Sefton. 1985. Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation. Proc. Natl. Acad. Sci. USA 82:4625-4628.
26. Klein, R. D., D. Sherman, W. H. Ho, D. Stone, G. L. Bennett, B. Moffat, R. Vandlen, L. Simmons, Q. Gu, J. A. Hongo, B. Devaux, K. Poulsen, M. Armanini, C. Nozaki, N. Asai, A. Goddard, H. Phillips, C. E. Henderson, M. Takahashi, and A. Rosenthal. 1997. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 387:717-721.
27. Kornau, H. C., L. T. Schenker, M. B. Kennedy, and P. H. Seeburg. 1995. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269:1737-1740.
28. Kotzbauer, P. T., P. A. Lampe, R. O. Heuckeroth, J. P. Golden, D. J. Creedon, E. M. Johnson, and J. Milbrandt. 1996. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384:467-470.
29. Kunkel, T. A., K. Benebek, and J. McClary. 1991. Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol. 204:125-139.
30. Kupperman, E., W. Wen, and J. L. Meinkoth. 1993. Inhibition of thyrotropin-stimulated DNA synthesis by microinjection of inhibitors of cellular Ras and cyclic AMP-dependent protein kinase. Mol. Cell. Biol. 13:4477-4484.
31. Laminet, A. A., G. Apell, L. Conroy, and W. M. Kavanaugh. 1996. Affinity, specificity, and kinetics of the interaction of the SHC phosphotyrosine binding domain with asparagine-X-X-phosphotyrosine motifs of growth factor receptors. J. Biol. Chem. 271:264-269.
32. Lanzi, C., M. G. Borello, I. Bongarzone, A. Migliazza, A. Fusco, M. Grieco, M. Santoro, R. A. Gambetta, F. Zunino, G. Della Porta, and M. A. Pierotti. 1992. Identification of the product of two oncogenic rearranged forms of the RET proto-oncogene in papillary thyroid carcinomas. Oncogene 7:2189-2194.
33. Lin, L. H., D. H. Doherty, J. D. Lile, S. Bektesh, and F. Collins. 1993. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132.
34. Lowenstein, E. J., R. J. Daly, A. G. Balzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E. Y. Skolnik, D. Bar-Sagi, and J. Schlessinger. 1992. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431-442.
35. Moore, M. W., R. D. Klein, I. Farinas, H. Sauer, M. Armanini, H. Phillips, L. F. Reichardt, A. M. Ryan, K. Carver-Moore, and A. Rosenthal. 1996. Renal and neuronal abnormalities in mice lacking GDNF. Nature 382:76-79.
36. Muller, B. M., U. Kistner, S. Kindler, W. J. Chung, S. Kuhlendahl, S. D. Fenster, L. F. Lau, R. W. Veh, R. L. Huganir, and E. D. Gundelfinger. 1996. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron 17:255-265.
37. Mulligan, L. M., C. Eng, C. S. Healey, D. Clayton, J. B. Kwok, E. Gardner, M. A. Ponder, A. Frilling, C. E. Jackson, H. Lehnert, H. Neumann, S. Thibodeau, and B. Ponder. 1994. Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC. Nat. Genet. 6:70-74.
38. Mulligan, L. M., J. B. J. Kwok, C. S. Healey, M. J. Elsdon, C. Eng, E. Gardner, D. R. Love, S. E. Mole, J. K. Moore, L. Papi, M. A. Ponder, H. Telenius, A. Tunnacliffe, and B. A. J. Ponder. 1993. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363:458-460.
39. Pasini, B., I. Ceccherini, and R. Giovanni. 1996. Ret mutations in human disease. Trends Genet. 12:138-144.
40. Pichel, J. G., L. Shen, H. Z. Sheng, A. Granholm, J. Drago, A. Grinberg, E. J. Lee, S. P. Huang, M. Saarma, B. J. Hoffer, H. Sariola, and H. Westphal. 1996. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382:73-76.
41. Pierotti, M. A., M. Santoro, R. B. Jenkins, G. Sozzi, I. Bongarzone, M. Grieco, N. Monzini, M. Miozzo, M. A. Herrmann, A. Fusco, I. D. Hay, G. D. Porta, and G. Vecchio. 1992. Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC. Proc. Natl. Acad. Sci. USA 89:1616-1620.
42. Pumiglia, K., Y. H. Chow, J. Fabian, D. Morrison, S. Decker, and R. Jove. 1995. Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction. Mol. Cell. Biol. 15:398-406.
43. Romeo, G., P. Ronchetto, Y. Luo, V. Barone, M. Seri, I. Ceccherini, B. Pasini, R. Bocciardi, M. Lerone, H. Kaariainen, and G. Martucciello. 1994. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature 367:377-378.
44. Sanchez, M. P., I. Silos-Santiago, J. Frisen, B. He, S. A. Lira, and M. Barbacid. 1996. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382:70-73.
45. Santoro, M., G. Chiappetta, A. Cerrato, D. Salvatore, L. Zhang, G. Manzo, A. Picone, G. Portella, G. Santelli, G. Vecchio, and A. Fusco. 1996. Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice. Oncogene 12:1821-1826.
46. Santoro, M., N. A. Dathan, M. T. Berlingieri, I. Bongarzone, C. Paulin, M. Grieco, M. A. Pierotti, G. Vecchio, and A. Fusco. 1994. Molecular characterization of RET/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma. Oncogene 9:509-516.
47. Santoro, M., W. T. Wong, P. Aroca, E. Santos, B. Maťoškovǎ, M. Grieco, A. Fusco, and P. P. Di Fiore. 1994. An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway. Mol. Cell. Biol. 14:663-675.
48. Saras, J., and C. H. Heldin. 1996. PDZ domains bind carboxy-terminal sequences of target proteins. Trends Biochem. Sci. 21:455-458.
49. Schuchardt, A., V. D'Agati, L. Larsson-Plomberg, F. Constantini, and V. Pachnis. 1994. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367:380-383.
50. Simske, J. S., S. M. Kaech, S. A. Harp, and S. K. Kim. 1996. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell 85:195-204.
51. Takahashi, M., J. Ritz, and G. M. Cooper. 1985. Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 42:581-588.
52. Tong, Q., S. Xing, and S. M. Jhiang. 1997. Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity. J. Biol. Chem. 272:9043-9047.
53. Treanor, J. J. S., L. Goodman, F. de Sauvage, D. M. Stone, K. T. Poulsen, C. D. Beck, C. Gray, M. P. Armanini, R. A. Pollock, F. Hefti, H. S. Phillips, A. Goddard, M. W. Moore, A. Buj-Bello, A. M. Davies, N. Asai, M. Takahashi, R. Vandlen, C. E. Henderson, and A. Rosenthal. 1996. Characterization of a multicomponent receptor for GDNF. Nature 382:80-83.
54. Trub, T., W. E. Choi, G. Wolf, E. Ottinger, Y. Chen, M. Weiss, and S. E. Shoelson. 1995. Specificity of the PTB domain of She for β turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. J. Biol. Chem. 270: 18205-18208.
55. van der Geer, P., T. Hunter, and R. A. Lindberg. 1994 Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10:251-337.
56. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
57. Wu, R. Y., K. Durick, Z. Songyang, L. C. Cantley, S. S. Taylor, and G. N. Gill. 1996. Specificity of LIM domain interactions with receptor tyrosine kinases. J. Biol. Chem. 271:15934-15941.
58. Wu, R. Y., and G. N. Gill. 1994. LIM domain recognition of a tyrosine-containing tight turn. J. Biol. Chem. 269:25085-25090.