Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas

American Journal of Pathology

Volumn 157, Issue 2, 2000, Pages 671-677

  La Perle, K M D ^a   Jhiang, S M ^a   Capen, C C ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; FEMALE; GENOTYPE; IMMUNOHISTOCHEMISTRY; METASTASIS; MITOSIS INDEX; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; THYROID CARCINOMA;

EID: 0033874066     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64577-4     Document Type: Article

References (48)

1. Carcinoma of follicular epithelium: Radioiodine and other treatments and outcomes
2. Epidemiology of thyroid cancer
3. Carcinoma of follicular epithelium: Pathogenesis
4. Pathologic features of thyroid tumors
5. Pathology of thyroid tumours
6. Tumors of the thyroid gland: Undifferentiated (anaplastic) carcinoma
7. Histologic typing of thyroid tumours
8. Papillary thyroid carcinoma: The impact of therapy in 576 patients
9. Miscellaneous tumors of the thyroid
10. Detection of the PTC/ret(TPC) oncogene in human thyroid cancers
11. Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype
12. RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes
13. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
14. Overexpression of p53 as a possible prognostic factor in human thyroid carcinoma
15. Stepwise participation of p53 gene mutation during dedifferentiation of human thyroid carcinomas
16. Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland
17. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas
18. p53 gene mutation in thyroid carcinoma
19. Retinoblastoma and p53 tumour suppressor gene protein expression in carcinomas of the thyroid gland
20. Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland
21. p53 expression in anaplastic carcinomas arising from thyroid papillary carcinomas
22. p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas
23. Genetic alterations in human epithelial thyroid tumours
24. Origin and progression of thyroid epithelial tumours: Cellular and molecular mechanisms
25. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas
26. Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice
27. Thyroid-stimulating hormone promotes growth of thyroid carcinomas in transgenic mice with targeted expression of the ret/PTC1 oncogene
28. Tumor spectrum analysis in p53-mutant mice
29. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
30. Effects of genetic background on tumorigenesis in p53-deficient mice
31. Genetic background alters the spectrum of tumors that develop in p53-deficient mice
32. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice
33. A mutant p53 transgene accelerates tumour development in hererozygous but not nullizygous p53-deficient mice
34. Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene
35. A mutated p53 gene alters thyroid cell differentiation
36. Reexpression of thyroid peroxidase in a derivative of an undifferentiated thyroid carcinoma cell line by introduction of wild-type p53
37. p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells
38. A cancer family syndrome in twenty-four kindreds
39. Tumors associated with p53 germline mutations: A synopsis of 91 families
40. Early occurrence of metastatic differentiated thyroid carcinomas in transgenic mice expressing the A2a adenosine receptor gene and the human papillomavirus type 16 E7 oncogene
41. Thyroid adenocarcinomas secondary to tissue-specific expression of simian virus-40 large T-antigen in transgenic mice
42. Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism
43. Differentiated carcinomas develop as a consequence of the thyroid specific expression of a thyroglobulin-human papillomavirus type 16 E7 transgene
44. Costimulation of adenylyl cyclase and phospholipase C by a mutant α(1b) adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells
45. Oncogenic potential of guanine nucleotide stimulatory factor α subunit in thyroid glands of transgenic mice
46. The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids
47. Thyroid pathologies in transgenic mice expressing a human activated ras gene driven by a thyroglobulin promoter
48. Production of transgenic mice expressing the Ki-ras oncogene under the control of a thyroglobulin promoter