BRAF mutations are not a major event in post-chernobyl childhood thyroid carcinomas

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 9, 2004, Pages 4267-4271

  Lima, Jorge ^a,b   Trovisco, Vítor ^a,b   Soares, Paula ^a,b   Máximo, Valdemar ^a   Magalhães, João ^a,c   Salvatore, Giuliana ^d   Santoro, Massimo ^d   Bogdanova, Tatyana ^e   Tronko, Mykola ^e   Abrosimov, Alexander ^a,f   Jeremiah, Steve ^g   Thomas, Gerry ^g   Williams, Dillwyn ^h   Sobrinho Simões, Manuel ^a,b,c  

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e V P Komisarenko Institute of Endocrinology and Metabolism of the Ukraine Academy of Medical Sciences   (Ukraine)

^f MEDICAL RADIOLOGICAL RESEARCH CENTER   (Russian Federation)

^g SINGLETON HOSPITAL   (United Kingdom)

^h UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; RAF PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; CHERNOBYL ACCIDENT; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; MALE; ONCOGENE RET; PAPILLARY CARCINOMA; PREVALENCE; PRIORITY JOURNAL; PROTO ONCOGENE; RADIATION EXPOSURE; SEX DIFFERENCE; THYROID CARCINOMA; THYROID PAPILLARY CARCINOMA;

ACCIDENTS, RADIATION; CARCINOMA, PAPILLARY; CHILD; FEMALE; GENE REARRANGEMENT; HUMANS; MALE; MUTATION; NEOPLASMS, RADIATION-INDUCED; ONCOGENE PROTEINS; POWER PLANTS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; THYROID NEOPLASMS; UKRAINE;

EID: 4544324693     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-032224     Document Type: Article

References (31)

1. Thomas GA, Bunnell H, Cook HA, Williams ED, Nerovnya A, Cherstvoy ED, Tronko ND, Bogdanova TI, Chiappetta G, Viglietto G, Pentimalli F, Salvatore G, Fusco A, Santoro M, Vecchio G 1999 High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. J Clin Endocrinol Metab 84:4232-4238
2. Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H, Fagin JA 1997 Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res 57:1690-1694
3. Beimfohr C, Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM 1999 NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accident. Int J Cancer 80:842-847
4. Suchy B, Waldmann V, Klugbauer S, Rabes HM 1998 Absence of RAS and p53 mutations in thyroid carcinomas of children after Chernobyl in contrast to adult thyroid rumours. Br J Cancer 77:952-955
5. Nikiforov YE, Nikiforova MN, Gnepp DR, Fagin JA 1996 Prevalence of mutations of ras and p53 in benign and malignant thyroid tumors from children exposed to radiation after the Chernobyl nuclear accident. Oncogene 13:687-693
6. Santoro M, Thomas GA, Vecchio G, Williams GH, Fusco A, Chiappetta G, Pozcharskaya V, Bogdanova TI, Demidchik EP, Cherstvoy ED, Voscoboinik L, Tronko ND, Carss A, Bunnell H, Tonnachera M, Parma J, Dumont JE, Keller G, Hofler H, Williams ED 2000 Gene rearrangement and Chernobyl related thyroid cancers. Br J Cancer 82:315-322
7. Singer G, Oldt III R, Cohen Y, Wang BG, Sidransky D, Kurman RJ, Shih I 2003 Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 95:484-486
8. Naoki K, Chen TH, Richards WG, Sugarbaker DJ, Meyerson M 2002 Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Res 62:7001-7003
9. Brose MS, Volpe P, Feldman M, Kumar M, Rishi I, Gerrero R, Einhorn E, Herlyn M, Minna J, Nicholson A, Roth JA, Albelda SM, Davies H, Cox C, Brignell G, Stephens P, Futreal PA, Wooster R, Stratton MR, Weber BL 2002 BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 62:6997-7000
10. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE 2002 Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 418:934
11. Pollock PM, Meltzer PS 2002 A genome-based strategy uncovers frequent BRAF mutations in melanoma. Cancer Cell 2:5-7
12. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA 2002 Mutations of the BRAF gene in human cancer. Nature 417:949-954
13. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA 2003 High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63:1454-1457
14. Soares P, Trovisco V, Rocha AS, Lima J, Castro P, Preto A, Maximo V, Botelho T, Seruca R, Sobrinho-Simoes M 2003 BRAF mutations and RET/PTC rear-rangements are alternative events in the etiopathogenesis of PTC. Oncogene 22:4578-4580
15. Cohen Y, Xing M, Mambo E, Guo Z, Wu G, Trink B, Beller U, Westra WH, Ladenson PW, Sidransky D 2003 BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 95:625-627
16. Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, Moses TY, Hostetter G, Wagner U, Kakareka J, Salem G, Pohida T, Heenan P, Duray P, Kallioniemi O, Hayward NK, Trent JM, Meltzer PS 2003 High frequency of BRAF mutations in nevi. Nat Genet 33:19-20
17. Peyssonnaux C, Eychene A 2001 The Raf/MEK/ERK pathway: new concepts of activation. Biol Cell 93:53-62
18. Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF 2001 Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res 56:127-155
19. Kolch W 2000 Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351:289-305
20. Kumar R, Angelini S, Hemminki K 2003 Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9. Oncogene 22:9217-9224
21. Trovisco V, Vieira de Castro I, Soares P, Maximo V, Silva P, Magalhaes J, Abrosimov A, Guiu XM, Sobrinho-Simoes M 2004 BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J Pathol 202:247-251
22. Nikiforova MN, Kimura ET, Gandhi M, Biddinger PW, Knauf JA, Basolo F, Zhu Z, Giannini R, Salvatore G, Fusco A, Santoro M, Fagin JA, Nikiforov YE 2003 BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab 88:5399-5404
23. Fukushima T, Suzuki S, Mashiko M, Ohtake T, Endo Y, Takebayashi Y, Sekikawa K, Hagiwara K, Takenoshita S 2003 BRAF mutations in papillary carcinomas of the thyroid. Oncogene 22:6455-6457
24. Namba H, Nakashima M, Hayashi T, Hayashida N, Maeda S, Rogounovitch TI, Ohtsuru A, Saenko VA, Kanematsu T, Yamashita S 2003 Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J Clin Endocrinol Metab 88:4393-4397
25. Xu X, Quiros RM, Gattuso P, Ain KB, Prinz RA 2003 High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res 63:4561-4567
26. Xing M, Vasko V, Tallini G, Larin A, Wu G, Udelsman R, Ringel MD, Ladenson PW, Sidransky D 2004 BRAF T1796A transversion mutation in various thyroid neoplasms. J Clin Endocrinol Metab 89:1365-1368
27. Harach HR, Williams ED 1995 Childhood thyroid cancer in England and Wales. Br J Cancer 72:777-783
28. Williams D 2002 Cancer after nuclear fallout: lessons from the Chernobyl accident. Nat Rev Cancer 2:543-549
29. Nikiforov YE 2002 RET/PTC rearrangement in thyroid tumors. Endocr Pathol 13:3-16
30. Williams GH, Rooney S, Thomas GA, Cummins G, Williams ED 1996 RET activation in adult and childhood papillary thyroid carcinoma using a reverse transcriptase-n-polymerase chain reaction approach on archival-nested material. Br J Cancer 74:585-589
31. Dahm-Daphi J, Sass C, Alberti W 2000 Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells. Int J Radiat Biol 76:67-75