-
1
-
-
0036295515
-
Molecular mechanisms of RET activation in human cancer
-
Santoro M, Melillo RM, Carlomagno F, Fusco A, Vecchio G 2002 Molecular mechanisms of RET activation in human cancer. Ann NY Acad Sci 963:116-121
-
(2002)
Ann NY Acad Sci
, vol.963
, pp. 116-121
-
-
Santoro, M.1
Melillo, R.M.2
Carlomagno, F.3
Fusco, A.4
Vecchio, G.5
-
2
-
-
0028825189
-
RET/PTC oncogene activation is an early event in thyroid carcinogenesis
-
Viglietto G, Chiappetta G, Martinez-Tello FJ, Tallini G, Rigopoulou D, Visconti R, Mastro A, Santoro M, Fusco A 1995 RET/PTC oncogene activation is an early event in thyroid carcinogenesis. Oncogene 11:1207-1210
-
(1995)
Oncogene
, vol.11
, pp. 1207-1210
-
-
Viglietto, G.1
Chiappetta, G.2
Martinez-Tello, F.J.3
Tallini, G.4
Rigopoulou, D.5
Visconti, R.6
Mastro, A.7
Santoro, M.8
Fusco, A.9
-
3
-
-
0031792561
-
Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia
-
Sugg SL, Ezzat S, Rosen IB, Freeman JL, Asa SL 1998 Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia. J Clin Endocrinol Metab 83:4116-4122
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 4116-4122
-
-
Sugg, S.L.1
Ezzat, S.2
Rosen, I.B.3
Freeman, J.L.4
Asa, S.L.5
-
4
-
-
0035209830
-
Frequent RET rearrangements in thyroid papillary microcarcinoma detected by interphase fluorescence in situ hybridization
-
Corvi R, Martinez-Alfaro M, Harach HR, Zini M, Papotti M, Romeo G 2001 Frequent RET rearrangements in thyroid papillary microcarcinoma detected by interphase fluorescence in situ hybridization. Lab Invest 81:1639-1645
-
(2001)
Lab Invest
, vol.81
, pp. 1639-1645
-
-
Corvi, R.1
Martinez-Alfaro, M.2
Harach, H.R.3
Zini, M.4
Papotti, M.5
Romeo, G.6
-
5
-
-
0029671246
-
Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas
-
Jhiang SM, Sagartz JE, Tong Q, Parker-Thornburg J, Capen CC, Cho JY, Xing S, Ledent C 1996 Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology 137:375-378
-
(1996)
Endocrinology
, vol.137
, pp. 375-378
-
-
Jhiang, S.M.1
Sagartz, J.E.2
Tong, Q.3
Parker-Thornburg, J.4
Capen, C.C.5
Cho, J.Y.6
Xing, S.7
Ledent, C.8
-
6
-
-
9244255770
-
Development of thyroid papillary carcinomas secondary to tissue- specific expression of the RET/PTC1 oncogene in transgenic mice
-
Santoro M, Chiappetta G, Cerrato A, Salvatore D, Zhang L, Manzo G, Picone A, Portella G, Santelli G, Vecchio G, Fusco A 1996 Development of thyroid papillary carcinomas secondary to tissue- specific expression of the RET/PTC1 oncogene in transgenic mice. Oncogene 12:1821-1826
-
(1996)
Oncogene
, vol.12
, pp. 1821-1826
-
-
Santoro, M.1
Chiappetta, G.2
Cerrato, A.3
Salvatore, D.4
Zhang, L.5
Manzo, G.6
Picone, A.7
Portella, G.8
Santelli, G.9
Vecchio, G.10
Fusco, A.11
-
7
-
-
3643067689
-
The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids
-
Powell Jr DJ, Russell J, Nibu K, Li G, Rhee E, Liao M, Goldstein M, Keane WM, Santoro M, Fusco A, Rothstein JL 1998 The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids. Cancer Res 58:5523-5528
-
(1998)
Cancer Res
, vol.58
, pp. 5523-5528
-
-
Powell Jr., D.J.1
Russell, J.2
Nibu, K.3
Li, G.4
Rhee, E.5
Liao, M.6
Goldstein, M.7
Keane, W.M.8
Santoro, M.9
Fusco, A.10
Rothstein, J.L.11
-
8
-
-
0027305591
-
In vitro irradiation is able to cause RET oncogene rearrangement
-
Ito T, Seyama T, Iwamoto KS, Hayashi T, Mizuno T, Tsuyama N, Dohi K, Nakamura N, Akiyama M 1993 In vitro irradiation is able to cause RET oncogene rearrangement. Cancer Res 53:2940-2943
-
(1993)
Cancer Res
, vol.53
, pp. 2940-2943
-
-
Ito, T.1
Seyama, T.2
Iwamoto, K.S.3
Hayashi, T.4
Mizuno, T.5
Tsuyama, N.6
Dohi, K.7
Nakamura, N.8
Akiyama, M.9
-
9
-
-
0030881411
-
Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis
-
Mizuno T, Kyoizumi S, Suzuki T, Iwamoto KS, Seyama T 1997 Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis. Oncogene 15:1455-1460
-
(1997)
Oncogene
, vol.15
, pp. 1455-1460
-
-
Mizuno, T.1
Kyoizumi, S.2
Suzuki, T.3
Iwamoto, K.S.4
Seyama, T.5
-
10
-
-
0033524002
-
Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas
-
Nikiforov YE, Koshoffer A, Nikiforova M, Stringer J, Fagin JA 1999 Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas. Oncogene 18:6330-6334
-
(1999)
Oncogene
, vol.18
, pp. 6330-6334
-
-
Nikiforov, Y.E.1
Koshoffer, A.2
Nikiforova, M.3
Stringer, J.4
Fagin, J.A.5
-
11
-
-
0034613291
-
Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells
-
Nikiforova MN, Stringer JR, Blough R, Medvedovic M, Fagin JA, Nikiforov YE 2000 Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. Science 290:138-141
-
(2000)
Science
, vol.290
, pp. 138-141
-
-
Nikiforova, M.N.1
Stringer, J.R.2
Blough, R.3
Medvedovic, M.4
Fagin, J.A.5
Nikiforov, Y.E.6
-
12
-
-
4544365901
-
Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas
-
Unger K, Zitzelsberger H, Salvatore G, Santoro M, Bogdanova T, Braselmann H, Kastner P, Zurnadzhy L, Tronko N, Hutzlet P, Thomas G 2004 Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas. J Clin Endocrinol Metab 89:4272-4279
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4272-4279
-
-
Unger, K.1
Zitzelsberger, H.2
Salvatore, G.3
Santoro, M.4
Bogdanova, T.5
Braselmann, H.6
Kastner, P.7
Zurnadzhy, L.8
Tronko, N.9
Hutzlet, P.10
Thomas, G.11
-
13
-
-
0026763062
-
Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype
-
Santoro M, Carlomagno F, Hay ID, Herrmann MA, Grieco M, Melillo R, Pierotti MA, Bongarzone I, Della Porta G, Berger N, Peix JL, Paulin C, Fabien N, Vecchio G, Jenkins RB, Fusco A 1992 Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. J Clin Invest 89:1517-1522
-
(1992)
J Clin Invest
, vol.89
, pp. 1517-1522
-
-
Santoro, M.1
Carlomagno, F.2
Hay, I.D.3
Herrmann, M.A.4
Grieco, M.5
Melillo, R.6
Pierotti, M.A.7
Bongarzone, I.8
Della Porta, G.9
Berger, N.10
Peix, J.L.11
Paulin, C.12
Fabien, N.13
Vecchio, G.14
Jenkins, R.B.15
Fusco, A.16
-
14
-
-
0037115405
-
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
-
Carlomagno F, Vitagliano D, Guida T, Ciardiello F, Tortora G, Vecchio G, Ryan AJ, Fontanini G, Fusco A, Santoro M 2002 ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 62:7284-7290
-
(2002)
Cancer Res
, vol.62
, pp. 7284-7290
-
-
Carlomagno, F.1
Vitagliano, D.2
Guida, T.3
Ciardiello, F.4
Tortora, G.5
Vecchio, G.6
Ryan, A.J.7
Fontanini, G.8
Fusco, A.9
Santoro, M.10
-
15
-
-
0034762203
-
The Raf/MEK/ERK pathway: New concepts of activation
-
Peyssonnaux C, Eychene A 2001 The Raf/MEK/ERK pathway: new concepts of activation. Biol Cell 93:53-62
-
(2001)
Biol Cell
, vol.93
, pp. 53-62
-
-
Peyssonnaux, C.1
Eychene, A.2
-
16
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigier HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA 2002 Mutations of the BRAF gene in human cancer. Nature 417:949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmieri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigier, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
17
-
-
1842735328
-
Oncogenic B-Raf mutations: Crystal clear at last
-
Dhillon AS, Kolch W 2004 Oncogenic B-Raf mutations: crystal clear at last. Cancer Cell 5:303-304
-
(2004)
Cancer Cell
, vol.5
, pp. 303-304
-
-
Dhillon, A.S.1
Kolch, W.2
-
18
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling path way by oncogenic mutations of B-RAF
-
Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R; Cancer Genome Project 2004 Mechanism of activation of the RAF-ERK signaling path way by oncogenic mutations of B-RAF. Cell 116:855-867
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
Jones, C.M.7
Marshall, C.J.8
Springer, C.J.9
Barford, D.10
Marais, R.11
-
19
-
-
0037379904
-
High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
-
Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA 2003 High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63:1454-1457
-
(2003)
Cancer Res
, vol.63
, pp. 1454-1457
-
-
Kimura, E.T.1
Nikiforova, M.N.2
Zhu, Z.3
Knauf, J.A.4
Nikiforov, Y.E.5
Fagin, J.A.6
-
20
-
-
1142287286
-
BRAF mutations are associated with some histological types of papillary thyroid carcinoma
-
Trovisco V, Vieira de Castro I, Soares P, Maximo V, Silva P, Magalhaes J, Abrosimov A, Guiu XM, Sobrinho-Simoes M 2004 BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J Pathol 202:247-251
-
(2004)
J Pathol
, vol.202
, pp. 247-251
-
-
Trovisco, V.1
Vieira De Castro, I.2
Soares, P.3
Maximo, V.4
Silva, P.5
Magalhaes, J.6
Abrosimov, A.7
Guiu, X.M.8
Sobrinho-Simoes, M.9
-
21
-
-
10744222003
-
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
-
Nikiforova MN, Kimura ET, Gandhi M, Biddinger PW, Knauf JA, Basolo F, Zhu Z, Giannini R, Salvatore G, Fusco A, Santoro M, Fagin JA, Nikiforov YE 2003 BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab 88:5399-5404
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 5399-5404
-
-
Nikiforova, M.N.1
Kimura, E.T.2
Gandhi, M.3
Biddinger, P.W.4
Knauf, J.A.5
Basolo, F.6
Zhu, Z.7
Giannini, R.8
Salvatore, G.9
Fusco, A.10
Santoro, M.11
Fagin, J.A.12
Nikiforov, Y.E.13
-
22
-
-
0142135475
-
BRAF mutations in papillary carcinomas of the thyroid
-
Fukushima T, Suzuki S, Mashiko M, Ohtake T, Endo Y, Takebayashi Y, Sekikawa K, Hagiwara K, Takenoshita S 2003 BRAF mutations in papillary carcinomas of the thyroid. Oncogene 22:6455-6457
-
(2003)
Oncogene
, vol.22
, pp. 6455-6457
-
-
Fukushima, T.1
Suzuki, S.2
Mashiko, M.3
Ohtake, T.4
Endo, Y.5
Takebayashi, Y.6
Sekikawa, K.7
Hagiwara, K.8
Takenoshita, S.9
-
23
-
-
0141453014
-
Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
-
Namba H, Nakashima M, Hayashi T, Hayashida N, Maeda S, Rogounovitch TI, Ohtsuru A, Saenko VA, Kanematsu T, Yamashita S 2003 Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J Clin Endocrinol Metab 88:4393-4397
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4393-4397
-
-
Namba, H.1
Nakashima, M.2
Hayashi, T.3
Hayashida, N.4
Maeda, S.5
Rogounovitch, T.I.6
Ohtsuru, A.7
Saenko, V.A.8
Kanematsu, T.9
Yamashita, S.10
-
24
-
-
0041589377
-
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines
-
Xu X, Quiros RM, Gattuso F, Ain KB, Prinz RA 2003 High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res 63:4561-4567
-
(2003)
Cancer Res
, vol.63
, pp. 4561-4567
-
-
Xu, X.1
Quiros, R.M.2
Gattuso, F.3
Ain, K.B.4
Prinz, R.A.5
-
25
-
-
0043170833
-
BRAF mutations and RET/PTC rear-rangements are alternative events in the etiopathogenesis of PTC
-
Soares P, Trovisco V, Rocha AS, Lima J, Castro P, Preto A, Maximo V, Botelho T, Seruca R, Sobrinho-Simoes M 2003 BRAF mutations and RET/PTC rear-rangements are alternative events in the etiopathogenesis of PTC. Oncogene 22:4578-4580
-
(2003)
Oncogene
, vol.22
, pp. 4578-4580
-
-
Soares, P.1
Trovisco, V.2
Rocha, A.S.3
Lima, J.4
Castro, P.5
Preto, A.6
Maximo, V.7
Botelho, T.8
Seruca, R.9
Sobrinho-Simoes, M.10
-
26
-
-
0038664387
-
BRAF mutation in papillary thyroid carcinoma
-
Cohen Y, Xing M, Mambo E, Guo Z, Wu G, Trink B, Beller U, Westra WH, Ladenson PW, Sidransky D 2003 BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 95:625-627
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 625-627
-
-
Cohen, Y.1
Xing, M.2
Mambo, E.3
Guo, Z.4
Wu, G.5
Trink, B.6
Beller, U.7
Westra, W.H.8
Ladenson, P.W.9
Sidransky, D.10
-
27
-
-
4544314992
-
T1796A mutations in childhood carcinomas
-
T1796A mutations in childhood carcinomas. J Clin Endocrinol Metab 89: 4280-4284
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4280-4284
-
-
Kumagai, A.1
Namba, H.2
Saenko, V.3
Ashizawa, K.4
Ohsturu, A.5
Ito, M.6
Ishikawa, N.7
Sugino, K.8
Ito, K.9
Jeremiah, S.10
Thomas, G.A.11
Bogdanova, T.I.12
Tronko, M.D.13
Nagayasu, T.14
Shibata, Y.15
Yamashita, S.16
-
28
-
-
4544324693
-
BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas
-
Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M 2004 BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas. J Clin Endocrinol Metab 89:4267-4271
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4267-4271
-
-
Lima, J.1
Trovisco, V.2
Soares, P.3
Máximo, V.4
Magalhães, J.5
Salvatore, G.6
Santoro, M.7
Bogdanova, T.8
Tronko, M.9
Abrosimov, A.10
Jeremiah, S.11
Thomas, G.12
Williams, D.13
Sobrinho-Simões, M.14
-
29
-
-
2442642971
-
Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
-
Nikiforova MN, Ciampi R, Salvatore G, Santoro M, Gandhi M, Knauf JA, Thomas GA, Jeremiah S, Bogdanova TI, Tronko MD, Fagin JA, Nikiforov YE 2004 Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Cancer Lett 209:1-6
-
(2004)
Cancer Lett
, vol.209
, pp. 1-6
-
-
Nikiforova, M.N.1
Ciampi, R.2
Salvatore, G.3
Santoro, M.4
Gandhi, M.5
Knauf, J.A.6
Thomas, G.A.7
Jeremiah, S.8
Bogdanova, T.I.9
Tronko, M.D.10
Fagin, J.A.11
Nikiforov, Y.E.12
-
30
-
-
0030941779
-
Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children
-
Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H, Fagin JA 1997 Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res 57:1690-1694
-
(1997)
Cancer Res
, vol.57
, pp. 1690-1694
-
-
Nikiforov, Y.E.1
Rowland, J.M.2
Bove, K.E.3
Monforte-Munoz, H.4
Fagin, J.A.5
-
31
-
-
0033985035
-
Gene rearrangement and Chernobyl related thyroid cancers
-
Santoro M, Thomas GA, Vecchio G, Williams GH, Fusco A, Chiappetta G, Pozcharskaya V, Bogdanova TI, Demidchik EP, Cherstvoy ED, Voscoboinik L, Tronko ND, Carss A, Bunnell H, Tonnachera M, Parma J, Dumont JE, Keller G, Hofler H, Williams ED 2000 Gene rearrangement and Chernobyl related thyroid cancers. Br J Cancer 82:315-322
-
(2000)
Br J Cancer
, vol.82
, pp. 315-322
-
-
Santoro, M.1
Thomas, G.A.2
Vecchio, G.3
Williams, G.H.4
Fusco, A.5
Chiappetta, G.6
Pozcharskaya, V.7
Bogdanova, T.I.8
Demidchik, E.P.9
Cherstvoy, E.D.10
Voscoboinik, L.11
Tronko, N.D.12
Carss, A.13
Bunnell, H.14
Tonnachera, M.15
Parma, J.16
Dumont, J.E.17
Keller, G.18
Hofler, H.19
Williams, E.D.20
more..
-
32
-
-
0033559183
-
NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accident
-
Beimfohr C, Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM 1999 NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accident. Int J Cancer 80:842-847
-
(1999)
Int J Cancer
, vol.80
, pp. 842-847
-
-
Beimfohr, C.1
Klugbauer, S.2
Demidchik, E.P.3
Lengfelder, E.4
Rabes, H.M.5
|