Simplified discodermolide analogues: Synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 2846-2864

  Choy, Nakyen ^a   Shin, Youseung ^a   Nguyen, Phu Qui ^a   Curran, Dennis P ^a,b   Balachandran, Raghavan ^a   Madiraju, Charitha ^a   Day, Billy W ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b 1101 Chevron Sciences Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,9 DIHYDROXY 14 (4 HYDROXY 3,5 DIMETHYL 6 OXOTETRAHYDROPYRAN 2 YL) 2,8,10 TRIMETHYL 1 (1 METHYLPENTA 2,4 DIENYL)TETRADECA 6,11 DIENYL ESTER; 3,9 DIHYDROXY 14 (4 METHOXYMETHOXY 3,5 DIMETHYL 6 OXOTETRAHYDROPYRAN 2 YL) 2,8,10 TRIMETHYL 1 (1 METHYLPENTA 2,4 DIENYL)TETRADECA 6,11 DIENYL ESTER; 3,9 DIHYDROXY 14 (6 METHOXY 4 METHOXYMETHOXY 3,5 DIMETHYLTETRAHYDROPYRAN 2 YL) 2,8,10 TRIMETHYL 1 (1 METHYLPENTA 2,4 DIENYL)TETRADECA 6,11 DIENYL ESTER; 4 EPI 7 DEHYDROXY 14,16 DINORDISCODERMOLIDE DERIVATIVE; ANTINEOPLASTIC AGENT; CARBAMIC ACID DERIVATIVE; DISCODERMOLIDE; DISCODERMOLIDE DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE; STRUCTURE ACTIVITY RELATION; WITTIG REACTION;

ALKANES; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; BINDING, COMPETITIVE; CARBAMATES; CATTLE; CELL DIVISION; CRYSTALLOGRAPHY, X-RAY; LACTONES; MICROTUBULES; PACLITAXEL; PYRONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 0038460882     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0204136     Document Type: Article

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