Structural basis of chemokine receptor function - A model for binding affinity and ligand selectivity

Bioscience Reports

Volumn 26, Issue 5, 2006, Pages 325-339

  Rajagopalan, Lavanya ^a   Rajarathnam, Krishna ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Binding affinity; Chemokine; Chemokine receptor; GPCR; N terminal domain; Receptor activation structure function; Selectivity

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; CHEMOKINE RECEPTOR CXCR6; G PROTEIN COUPLED RECEPTOR; GAG PROTEIN; INTERLEUKIN 8; RANTES;

AMINO TERMINAL SEQUENCE; AUTOIMMUNITY; BINDING AFFINITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISULFIDE BOND; DRUG TARGETING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLAMMATION; LEUKOCYTE MIGRATION; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS PATHOGENESIS;

ANIMALS; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CHEMOKINE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 33750929921     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10540-006-9025-9     Document Type: Review

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