Cholesterol is essential for macrophage inflammatory protein 1β binding and conformational integrity of CC chemokine receptor 5

Blood

Volumn 99, Issue 12, 2002, Pages 4298-4306

  Nguyen, Dzung H ^a   Taub, Dennis ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CHEMOKINE RECEPTOR CCR5; CHOLEST 4 EN 3 ONE; CHOLESTEROL; EPITOPE; FLUORESCENT DYE; GANGLIOSIDE GM1; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RECEPTOR ANTIBODY;

ARTICLE; CONTROLLED STUDY; FLUORESCENCE; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; LIGAND BINDING; MEMBRANE BINDING; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

EID: 0037097585     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2001-11-0087     Document Type: Article

References (42)

1. CC CKR5: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1
2. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
3. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC- CKR-5
4. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
5. Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype
6. Chemokines: Immunology's high impact factors
7. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
8. Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function
9. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
10. A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor
11. A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5
12. Structure and function of sphingolipid- and cholesterol-rich membrane rafts
13. Fc(epsilon)RI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells
14. The amplification of TCR signaling by dynamic membrane microdomains
15. Floating the raft hypothesis: The roles of lipid rafts in B cell antigen receptor function
16. Membrane raft microdomains mediate front-rear polarity in migrating cells
17. Palmitoylation-dependent control of degradation, life span and membrane expression of the CCR5 receptor
18. Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways
19. Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 which regulate signaling and receptor internalization
20. Cellular cholesterol efflux mediated by cyclodextrins. Demonstration of kinetic pools and mechanism of efflux
21. Cholesterol as modulator of receptor function
22. Effects of membrane cholesterol on the sensitivity of the GABA(A) receptor to GABA in acutely dissociated rat hippocampal neurones
23. Membrane cholesterol modulates galanin-GaIR2 interaction
24. Demonstration that platelet-activating factor is capable of activating mast cells and inducing a chemotactic response
25. A cell line-based neutralization assay for primary human immunodeficiency virus type 1 isolates that use either the CCR5 or the CXCR4 co-receptor
26. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function
27. Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection
28. Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization
29. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
30. Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5
31. Lipid rafts and HIV pathogenesis: Host membrane cholesterol is required for infection by HIV type 1
32. SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis
33. Characterization of new syncytium-inhibiting monoclonal antibodies implicates lipid rafts in human T-cell leukemia virus type 1 syncytium formation
34. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts
35. Assembly of Sendai virus: M protein interacts with F and HN proteins and with the cytoplasmic tail and transmembrane domain of F protein
36. Influenza virus assembly: Effect of influenza virus glycoproteins on the membrane association of M1 protein
37. Measles virus structural components are enriched into lipid raft microdomains: A potential cellular location for virus assembly
38. Influenza viruses select ordered lipid domains during budding from the plasma membrane
39. Lipid rafts and pseudotyping
40. Chemokines and disease
41. Oxidative damage and mitochondrial decay in aging
42. CXCR4 function requires membrane cholesterol: Implications for HIV infection