Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES: Characterization of active disaggregated chemokine variants

Journal of Biological Chemistry

Volumn 274, Issue 23, 1999, Pages 16077-16084

  Czaplewski, Lloyd G ^a   McKeating, Jane ^b   Craven, C Jeremy ^c   Higgins, Lee D ^c   Appay, Victor ^a   Brown, Anthony ^a   Dudgeon, Tim ^a   Howard, Lesley A ^a   Meyers, Tim ^a   Owen, Jo ^a   Palan, Shilpa R ^a   Tan, Paul ^a   Wilson, Giles ^a   Woods, Nigel R ^a   Heyworth, Clare M ^d   Lord, Brian I ^d   Brotherton, Deb ^a,f   Christison, Richard ^a,g   Craig, Stewart ^a,h   Cribbes, Scott ^a,i   Edwards, R Mark ^a,j   Evans, Steve J ^a,k   Gilbert, Richard ^a   Morgan, Pete ^a,l   Randle, Eliot ^a,m   Schofield, Neil ^a   Varley, Paul G ^a,n   Fisher, Julie ^e   Waltho, Jonathan P ^c   Hunter, Michael G ^a   more..

^a British Biotech Pharmaceuticals Ltd   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d CHRISTIE HOSPITAL   (United Kingdom)

^e UNIVERSITY OF LEEDS   (United Kingdom)

^f Dept of Biochemistry ^*  (United Kingdom)

^g ASTRAZENECA   (United Kingdom)

^h OSIRIS THERAPEUTICS INC   (United States)

ⁱ BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^j Oxagen   (United Kingdom)

^k NEWCASTLE UNIVERSITY   (United Kingdom)

^l Murex Biotech Ltd   (United Kingdom)

^m Prolifix Ltd   (United Kingdom)

ⁿ MEDIMMUNE LTD   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC ACID; BETA CHEMOKINE; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; MACROPHAGE; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; AMINO ACIDS; CELL LINE; HIV INFECTIONS; HIV-1; HUMANS; MACROPHAGE INFLAMMATORY PROTEIN-1; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE LIBRARY; PROTEIN CONFORMATION; RANTES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0033522887     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.23.16077     Document Type: Article

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