Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region

Journal of Immunology

Volumn 165, Issue 9, 2000, Pages 5295-5303

  Preobrazhensky, A A ^a   Dragan, S ^a   Kawano, T ^a   Gavrilin, M A ^a   Gulina, I V ^a   Chakravarty, L ^a   Kolattukudy, P E ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CHEMOKINE RECEPTOR; GLYCOPROTEIN; GLYCOSIDASE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUNICAMYCIN; TYROSINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM TRANSPORT; CHEMOTAXIS; CONSENSUS SEQUENCE; EMBRYO; EXTRACELLULAR MATRIX; GLYCOSYLATION; HUMAN; HUMAN CELL; LAMELLIPODIUM; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SULFATION;

EID: 0034327691     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.9.5295     Document Type: Article

References (68)

1. The molecular biology of leukocyte chemoattractant receptors
2. Chemokines
3. Chemokines: Chemotactic cytokines that mediate inflammation
4. Chemokines and leukocyte traffic
5. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
6. Tyrosine sulfation and the secretory pathway
7. Determination and occurrence of tyrosine O-sulfate in proteins
8. Tyrosylprotein sulfotransferase: Purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins
9. Existence of distinct tyrosylprotein sulfotransferase genes: Molecular characterization of tyrosylprotein sulfotransferase-2
10. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologne in Caenorhabditis elegans
11. New consensus features for tyrosine O-sulfation determined by mutational analysis
12. Kinetics of the inhibition of thrombin by hirudin
13. The effect of substituting phospbotyrosine for sulphotyrosine on the activity of hirudin
14. Sulfation of Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with yon Willebrand factor
15. PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus
16. Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin
17. The expression of monocyte cbemotactic protein (MCP- 1) in human vascular endothelium in vitro and in vivo
18. Site-directed mutagenesis of monocyte chemoattractant protein-1 identifies two regions of the polypeptide essential for biological activity
19. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails
20. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte cbemoattractant protein-1 receptor: Critical role of carboxyl-tail serines/threonines in receptor function
21. A calcium-dependent antibody for identification and purification of recombinant proteins
22. A general method of in vitro preparation and specific mutagenesis of DNA fragments: Study of protein and DNA interactions
23. Preparation of iodine-131 labeled human growth hormone of high specific affinity
24. Characterization and species distribution of high-affinity GTP-coupled receptors for human rantes and monocyte chemoattractant protein-1
25. Ligand: A versatile computerized approach for characterization of ligand-binding systems
26. The cloned platelet thrombin receptor couples to at least 2 distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
27. A highly sensitive adenylate cyclase assay
28. Signal-transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embryonic kidney-cells
29. Fluorescent phalloidin, a tool for the visualization of cellular actin
30. Characterization of the CCR2 chemokine receptor: Functional CCR2 receptor expression in B cells
31. The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1α receptor, confers chemokine selectivity: Evidence for a two-step mechanism for MCP-1 receptor activation
32. The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of rnonocyte chemoattractant protein 1: Receptor activation by a pseudo-tethered ligand
33. The cytomegalovirus US28 protein binds multiple CC-chemokines with high-affinity
34. Chemokine sequestration by viral chemoreceptors as a novel viral escape strategy: Withdrawal of chemokines from the environment of cytomegalovirus-infected cells
35. Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection
36. The many faces of G protein signaling
37. Mammalian RGS proteins: Barbarians at the gate
38. Receptors induce chemotaxis by releasing the βγ subunit of G(i), not by activating G(q) or G(s)
39. Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines
40. Monocyte chemoattractant protein-1: Receptor interactions and calcium signaling mechanisms
41. 2+ signal neutrophil chemotaxis in response to formylated chemotactic peptide?
42. Macrophage-derived chemokine induces human eosinopbil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner
43. 2+ influx, synergism with platelet-activating factor and significance for chemotaxis
44. MCP-1-mediated chemotaxis requires activation of non-overlapping signal transduction pathways
45. Gα(i) is not required for chemotaxis mediated by G(i)-coupled receptors
46. Inhibitory effect of sanguiin H-11 on chemotaxis of neutrophil
47. Signal pathway regulation of interleukin-8-induced actin polymerization in neutrophils
48. Rho GTPases and the actin cytoskeleton
49. A cell's sense of direction
50. Functional design in the actin cytoskeleton
51. Positive feedback interactions between microtubule and actin dynamics during cell motility
52. Adhesion in cell migration
53. Analysis of the actin-myosin II system in fish epidermal keratocytes: Mechanism of cell body translocation
54. Gelsolin is a downstream effector of rac for fibroblast motility
55. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts
56. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
57. Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: A mechanism for induction of chemotaxis
58. Spatial control of actin polymerization during neutrophil chemotaxis
59. Changes in the distribution of LFA-1, catenins and F-actin during transendothelial migration of monocytes in culture
60. Identification of N-terminal residues on P-selectin glycoprotein ligand-1 required for binding to P-selectin
61. The chemokine monocyte chemoattracrant protein-1 induces functional responses through dimerization of its receptor CCR2
62. Characterization of recombinant human CXCR4 in insect cells: Role of extracellular domains and N-glycosylation in ligand binding
63. Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors
64. Lysine 58 and histidine 66 at the C-terminal α-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding
65. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1
66. Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: Abrogation by a second transgene expressing systemic MCP-1
67. Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation
68. Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle