Role of the first extracellular loop in the functional activation of CCR2. The first extracellular loop contains distinct domains necessary for both agonist binding and transmembrane signaling

Journal of Biological Chemistry

Volumn 274, Issue 45, 1999, Pages 32055-32062

  Han, Ki Hoon ^a   Green, Simone R ^a   Tangirala, Rajendra K ^a,b   Tanaka, Seiya ^a   Quehenberger, Oswald ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; HISTIDINE; MONOCYTE CHEMOTACTIC PROTEIN 1; RECEPTOR ANTIBODY; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CHEMOKINE CCL2; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 0000113237     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.45.32055     Document Type: Article

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