-
1
-
-
33746396117
-
The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells
-
Ahmad, M., Long, J.S., Pyne, N.J., and Pyne, S. (2006). The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. Prostaglandins Other Lipid Mediat. 79, 278-286.
-
(2006)
Prostaglandins Other Lipid Mediat.
, vol.79
, pp. 278-286
-
-
Ahmad, M.1
Long, J.S.2
Pyne, N.J.3
Pyne, S.4
-
2
-
-
0035661664
-
HIF-1 expression in healing wounds: HIF-1α induction in primary inflammatory cells by TNF-α
-
Albina, J.E., Mastrofrancesco, B., Vessella, J.A., Louis, C.A., Henry, W.L. Jr., and Reichner, J.S. (2001). HIF-1 expression in healing wounds: HIF-1α induction in primary inflammatory cells by TNF-α. Am. J. Physiol. Cell. Physiol. 281, C1971-C1877.
-
(2001)
Am. J. Physiol. Cell. Physiol.
, vol.281
-
-
Albina, J.E.1
Mastrofrancesco, B.2
Vessella, J.A.3
Louis, C.A.4
Henry Jr., W.L.5
Reichner, J.S.6
-
3
-
-
0035971220
-
Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension
-
Aragones, J., Jones, D.R., Martin, S., San Juan, M.A., Alfranca, A., Vidal, F., Vara, A., Merida, I., and Landazuri, M.O. (2001). Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension. J. Biol. Chem. 276, 10548-10555.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10548-10555
-
-
Aragones, J.1
Jones, D.R.2
Martin, S.3
San Juan, M.A.4
Alfranca, A.5
Vidal, F.6
Vara, A.7
Merida, I.8
Landazuri, M.O.9
-
5
-
-
4043123181
-
+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: Ionic diversity in smooth muscle cells
-
+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ. Res. 95, 308-318.
-
(2004)
Circ. Res.
, vol.95
, pp. 308-318
-
-
Archer, S.L.1
Wu, X.C.2
Thebaud, B.3
Nsair, A.4
Bonnet, S.5
Tyrrell, B.6
McMurtry, M.S.7
Hashimoto, K.8
Harry, G.9
Michelakis, E.D.10
-
6
-
-
33750617776
-
Regulatory functions of protein kinase C isoenzymes in the kidney
-
Aschrafi, A., Shabahang, S., Pfeilschifter, J., and Huwiler, A. (2003). Regulatory functions of protein kinase C isoenzymes in the kidney. Curr. Top. Biochem. Res. 5, 27-41.
-
(2003)
Curr. Top. Biochem. Res.
, vol.5
, pp. 27-41
-
-
Aschrafi, A.1
Shabahang, S.2
Pfeilschifter, J.3
Huwiler, A.4
-
8
-
-
12144252951
-
Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation
-
Basnakian, A.G., Ueda, N., Hong, X., Galitovsky, V.E., Yin, X., and Shah, S.V. (2005). Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation. Am. J. Physiol. Renal Physiol. 288, F308-F314.
-
(2005)
Am. J. Physiol. Renal Physiol.
, vol.288
-
-
Basnakian, A.G.1
Ueda, N.2
Hong, X.3
Galitovsky, V.E.4
Yin, X.5
Shah, S.V.6
-
9
-
-
0037119456
-
Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1β and amyloid β 42 peptide is potentiated by hypoxia in primary human neural cells
-
Bazan, N.G. and Lukiw, W.J. (2002). Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1β and amyloid β 42 peptide is potentiated by hypoxia in primary human neural cells. J. Biol. Chem. 277, 30359-30367.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30359-30367
-
-
Bazan, N.G.1
Lukiw, W.J.2
-
10
-
-
0021443856
-
Inositol trisphosphate and diacylglycerol as second messengers
-
Berridge, M.J. (1984). Inositol trisphosphate and diacylglycerol as second messengers. Biochem. J. 220, 345-360.
-
(1984)
Biochem. J.
, vol.220
, pp. 345-360
-
-
Berridge, M.J.1
-
11
-
-
0030698045
-
Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion
-
Bielawska, A.E., Shapiro, J.P., Jiang, L., Melkonyan, H.S., Piot, C., Wolfe, C.L., Tomei, L.D., Hannun, Y.A., and Umansky, S.R. (1997). Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am. J. Pathol. 151, 1257-1263.
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 1257-1263
-
-
Bielawska, A.E.1
Shapiro, J.P.2
Jiang, L.3
Melkonyan, H.S.4
Piot, C.5
Wolfe, C.L.6
Tomei, L.D.7
Hannun, Y.A.8
Umansky, S.R.9
-
12
-
-
0034723274
-
Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium
-
Bonazzi, A., Mastyugin, V., Mieyal, P.A., Dunn, M.W., and Laniado-Schwartzman, M. (2000). Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium. J. Biol. Chem. 275, 2837-2844.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2837-2844
-
-
Bonazzi, A.1
Mastyugin, V.2
Mieyal, P.A.3
Dunn, M.W.4
Laniado-Schwartzman, M.5
-
13
-
-
33644685637
-
The role of protein kinase C in cerebral ischemic and reperfusion injury
-
Bright, R. and Mochly-Rosen, D. (2005). The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke 36, 2781-2790.
-
(2005)
Stroke
, vol.36
, pp. 2781-2790
-
-
Bright, R.1
Mochly-Rosen, D.2
-
14
-
-
0021187297
-
The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia
-
Busse, R., Förstermann, U., Matsuda, H., and Pohl, U. (1984). The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia. Pflüger's Arch. 401, 77-83.
-
(1984)
Pflüger's Arch.
, vol.401
, pp. 77-83
-
-
Busse, R.1
Förstermann, U.2
Matsuda, H.3
Pohl, U.4
-
15
-
-
18844413584
-
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1α accumulation - Implications for prolyl hydroxylase activity and iron
-
Callapina, M., Zhou, J., Schnitzer, S., Metzen, E., Lohr, C., Deitmer, J.W., and Brüne, B. (2005). Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1α accumulation - implications for prolyl hydroxylase activity and iron. Exp. Cell Res. 306, 274-284.
-
(2005)
Exp. Cell Res.
, vol.306
, pp. 274-284
-
-
Callapina, M.1
Zhou, J.2
Schnitzer, S.3
Metzen, E.4
Lohr, C.5
Deitmer, J.W.6
Brüne, B.7
-
16
-
-
1942422176
-
Regulation of limb development by the sphingosine 1-phosphate receptor S1P1/EDG-1 occurs via the hypoxia/VEGF axis
-
Chae, S.S., Paik, J.H., Allende, M.L., Proia, R.L., and Hla, T. (2004). Regulation of limb development by the sphingosine 1-phosphate receptor S1P1/EDG-1 occurs via the hypoxia/VEGF axis. Dev. Biol. 268, 441-447.
-
(2004)
Dev. Biol.
, vol.268
, pp. 441-447
-
-
Chae, S.S.1
Paik, J.H.2
Allende, M.L.3
Proia, R.L.4
Hla, T.5
-
17
-
-
0029939736
-
Effects of acute and chronic hypoxia on rat lung cyclooxygenase
-
Chida, M. and Voelkel, N.F. (1996). Effects of acute and chronic hypoxia on rat lung cyclooxygenase. Am. J. Physiol. 270, L872-L878.
-
(1996)
Am. J. Physiol.
, vol.270
-
-
Chida, M.1
Voelkel, N.F.2
-
18
-
-
0032032901
-
HPTLC analysis of sphingomylein, ceramide and sphingosine in ischemic/reperfused rat heart
-
Cordis, G.A., Yoshida, T., and Das, D.K. (1998). HPTLC analysis of sphingomylein, ceramide and sphingosine in ischemic/reperfused rat heart. J. Pharm. Biomed. Anal. 16, 1189-1193.
-
(1998)
J. Pharm. Biomed. Anal.
, vol.16
, pp. 1189-1193
-
-
Cordis, G.A.1
Yoshida, T.2
Das, D.K.3
-
19
-
-
0037423948
-
HIF-1α is essential for myeloid cell-mediated inflammation
-
Cramer, T., Yamanishi, Y., Clausen, B.E., Foster, I., Pawlinski, R., Mackman, N., Haase, V.H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003). HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112, 645-657.
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
Foster, I.4
Pawlinski, R.5
Mackman, N.6
Haase, V.H.7
Jaenisch, R.8
Corr, M.9
Nizet, V.10
-
20
-
-
0037117486
-
Structural basis for HIF-1α/CBP recognition in the cellular hypoxic response
-
Dames, S.A., Martinez-Yamout, M., De Guzman, R.N., Dyson, H.J., and Wright, P.E. (2002). Structural basis for HIF-1α/CBP recognition in the cellular hypoxic response. Proc. Natl. Acad. Sci. USA 99, 5271-5276.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5271-5276
-
-
Dames, S.A.1
Martinez-Yamout, M.2
De Guzman, R.N.3
Dyson, H.J.4
Wright, P.E.5
-
21
-
-
0141643249
-
Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis
-
Demasi, M., Cleland, L.G., Cook-Johnson, R.J., Caughey, G.E., and James, M.J. (2003). Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis. J. Biol. Chem. 278, 38607-38616.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38607-38616
-
-
Demasi, M.1
Cleland, L.G.2
Cook-Johnson, R.J.3
Caughey, G.E.4
James, M.J.5
-
22
-
-
0032842003
-
mRNA cloning and expression studies of the quail homologue of HIF-2α
-
Elvert, G., Lanz, S., Kappel, A., and Flamme, I. (1999). mRNA cloning and expression studies of the quail homologue of HIF-2α. Mech. Dev. 87, 193-197.
-
(1999)
Mech. Dev.
, vol.87
, pp. 193-197
-
-
Elvert, G.1
Lanz, S.2
Kappel, A.3
Flamme, I.4
-
23
-
-
27744599606
-
Regulation of the sphingolipid signaling pathways in the growing and hypoxic rat heart
-
El Alwani, M., Usta, J., Nemer, G., Sabban, M.E., Nasser, M., Bitar, H., Souki, R., Dbaibo, G.S., and Bitar, F.F. (2005). Regulation of the sphingolipid signaling pathways in the growing and hypoxic rat heart. Prostaglandins Other Lipid Mediat. 78, 249-263.
-
(2005)
Prostaglandins Other Lipid Mediat.
, vol.78
, pp. 249-263
-
-
El Alwani, M.1
Usta, J.2
Nemer, G.3
Sabban, M.E.4
Nasser, M.5
Bitar, H.6
Souki, R.7
Dbaibo, G.S.8
Bitar, F.F.9
-
24
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein, A.C., Gleadle, J.M., McNeill, L.A., Hewitson, K.S., O'Rourke, J., Mole, D.R., Mukherji, M., Metzen, E., Wilson, M.I., Dhanda, A., et al. (2001). C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
-
25
-
-
0030989336
-
2+ channel
-
2+ channel. J. Physiol. 500, 551-556.
-
(1997)
J. Physiol.
, vol.500
, pp. 551-556
-
-
Fearon, I.M.1
Palmer, A.C.2
Balmforth, A.J.3
Ball, S.G.4
Mikala, G.5
Schwartz, A.6
Peers, C.7
-
26
-
-
0029079409
-
Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation
-
Franco-Obregon, A., Urena, J., and Lopez-Barneo, J. (1995). Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation. Proc. Natl. Acad. Sci. USA 92, 4715-4719.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4715-4719
-
-
Franco-Obregon, A.1
Urena, J.2
Lopez-Barneo, J.3
-
27
-
-
0037117479
-
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
-
Freedman, S.J., Sun, Z.Y., Poy, F., Kung, A.L., Livingston, D.M., Wagner, G., and Eck, M.J. (2002). Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α. Proc. Natl. Acad. Sci. USA 99, 5367-5372.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5367-5372
-
-
Freedman, S.J.1
Sun, Z.Y.2
Poy, F.3
Kung, A.L.4
Livingston, D.M.5
Wagner, G.6
Eck, M.J.7
-
28
-
-
1842290997
-
Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes
-
Goldberg, M., Zhang, H.L., and Steinberg, S.F. (1997). Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes. J. Clin. Invest. 99, 55-61.
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 55-61
-
-
Goldberg, M.1
Zhang, H.L.2
Steinberg, S.F.3
-
29
-
-
0035816732
-
Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase
-
Görlach, A., Diebold, I., Schini-Kerth, V.B., Berchner-Pfannschmidt, U., Roth, U., Brandes, R.P., Kietzmann, T., and Busse, R. (2001). Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase. Circ. Res. 89, 47-54.
-
(2001)
Circ. Res.
, vol.89
, pp. 47-54
-
-
Görlach, A.1
Diebold, I.2
Schini-Kerth, V.B.3
Berchner-Pfannschmidt, U.4
Roth, U.5
Brandes, R.P.6
Kietzmann, T.7
Busse, R.8
-
30
-
-
33746655373
-
Hypoxia-inducible factors in the kidney
-
Haase, V.H. (2006). Hypoxia-inducible factors in the kidney. Am. J. Physiol. Renal Physiol. 291, F271-F281.
-
(2006)
Am. J. Physiol. Renal Physiol.
, vol.291
-
-
Haase, V.H.1
-
32
-
-
0035812789
-
Expression and characterization of hypoxia-inducible factor (HIF)-3α in human kidney: Suppression of HIF-mediated gene expression by HIF-3α
-
Hara, S., Hamada, J., Kobayashi, C., Kondo, Y., and Imura, N. (2001). Expression and characterization of hypoxia-inducible factor (HIF)-3α in human kidney: suppression of HIF-mediated gene expression by HIF-3α. Biochem. Biophys. Res. Commun. 287, 808-813.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.287
, pp. 808-813
-
-
Hara, S.1
Hamada, J.2
Kobayashi, C.3
Kondo, Y.4
Imura, N.5
-
33
-
-
0033181324
-
Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1
-
Hellwig-Burgel, T., Rutkowski, K., Metzen, E., Fandrey, J., and Jelkmann, W. (1999). Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1. Blood 94, 1561-1567.
-
(1999)
Blood
, vol.94
, pp. 1561-1567
-
-
Hellwig-Burgel, T.1
Rutkowski, K.2
Metzen, E.3
Fandrey, J.4
Jelkmann, W.5
-
34
-
-
0033973670
-
Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes
-
Hernandez, O.M., Discher, D.J., Bishopric, N.H., and Webster, W.A. (2000). Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes. Circ. Res. 86, 198-204.
-
(2000)
Circ. Res.
, vol.86
, pp. 198-204
-
-
Hernandez, O.M.1
Discher, D.J.2
Bishopric, N.H.3
Webster, W.A.4
-
35
-
-
22844437635
-
+ channels. Implications with respect to cardiac arrhythmia
-
+ channels. Implications with respect to cardiac arrhythmia. Eur. Biophys. J. 34, 369-376.
-
(2005)
Eur. Biophys. J.
, vol.34
, pp. 369-376
-
-
Hool, L.C.1
-
36
-
-
17744386137
-
Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma
-
Huang, S.P., Wu, M.S., Shun, C.T., Wang, H.P., Hsieh, C.Y., Kuo, M.L., and Lin, J.T. (2005). Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma. J. Biomed. Sci. 12, 229-241.
-
(2005)
J. Biomed. Sci.
, vol.12
, pp. 229-241
-
-
Huang, S.P.1
Wu, M.S.2
Shun, C.T.3
Wang, H.P.4
Hsieh, C.Y.5
Kuo, M.L.6
Lin, J.T.7
-
37
-
-
0027448972
-
A role for protein kinase C-α in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages
-
Huwiler, A. and Pfeilschifter, J. (1993). A role for protein kinase C-α in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages. Eur. J. Biochem. 217, 69-75.
-
(1993)
Eur. J. Biochem.
, vol.217
, pp. 69-75
-
-
Huwiler, A.1
Pfeilschifter, J.2
-
38
-
-
0025951511
-
Possible regulatory functions of protein kinase C-α and -ε isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis
-
Huwiler, A., Fabbro, D., and Pfeilschifter, J. (1991). Possible regulatory functions of protein kinase C-α and -ε isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis. Biochem. J. 279, 441-445.
-
(1991)
Biochem. J.
, vol.279
, pp. 441-445
-
-
Huwiler, A.1
Fabbro, D.2
Pfeilschifter, J.3
-
39
-
-
0034738011
-
Physiology and pathophysiology of sphingolipid metabolism and signaling
-
Huwiler, A., Kolter, T., Pfeilschifter, J., and Sandhoff, K. (2000). Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim. Biophys. Acta 1485, 63-99.
-
(2000)
Biochim. Biophys. Acta
, vol.1485
, pp. 63-99
-
-
Huwiler, A.1
Kolter, T.2
Pfeilschifter, J.3
Sandhoff, K.4
-
40
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1α
-
2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 12, 149-162.
-
(1998)
Genes Dev.
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
41
-
-
0021827229
-
Hypoxia enhances prostaglandin synthesis in renal mesangial cell cultures
-
Jelkmann, W., Kurtz, A., Förstermann, U., Pfeilschifter, J., and Bauer, C. (1985). Hypoxia enhances prostaglandin synthesis in renal mesangial cell cultures. Prostaglandins 30, 109-118.
-
(1985)
Prostaglandins
, vol.30
, pp. 109-118
-
-
Jelkmann, W.1
Kurtz, A.2
Förstermann, U.3
Pfeilschifter, J.4
Bauer, C.5
-
42
-
-
0036481770
-
Von Hippel Lindau tumor suppressor and HIF-1α: New targets of NSAIDs inhibition of hypoxia-induced angiogenesis
-
Jones, M.K., Szabo, I.L., Kawanaka, H., Husain, S.S., and Tarnawski, A.S. (2002). von Hippel Lindau tumor suppressor and HIF-1α: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis. FASEB J. 16, 264-266.
-
(2002)
FASEB J.
, vol.16
, pp. 264-266
-
-
Jones, M.K.1
Szabo, I.L.2
Kawanaka, H.3
Husain, S.S.4
Tarnawski, A.S.5
-
43
-
-
0022391128
-
Role of prostaglandins in hypoxia-stimulated erythropoietin production
-
Kurtz, A., Jelkmann, W., Pfeilschifter, J., and Bauer, C. (1985). Role of prostaglandins in hypoxia-stimulated erythropoietin production. Am. J. Physiol. 249, C3-C8.
-
(1985)
Am. J. Physiol.
, vol.249
-
-
Kurtz, A.1
Jelkmann, W.2
Pfeilschifter, J.3
Bauer, C.4
-
44
-
-
0037146555
-
2 induces hypoxia-inducible factor-1α stabilization and nuclear localization in a human prostate cancer cell line
-
2 induces hypoxia-inducible factor-1α stabilization and nuclear localization in a human prostate cancer cell line. J. Biol. Chem. 277, 50081-50006.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50081-50006
-
-
Liu, X.H.1
Kirschenbaum, A.2
Lu, M.3
Yao, S.4
Dosoretz, A.5
Holland, J.F.6
Levine, A.C.7
-
47
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon, P.C., Hirota, K., and Semenza, G.L. (2001). FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15, 2675-2686.
-
(2001)
Genes Dev.
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
48
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P.H., Wiesener, M.S., Chang, G.W., Clifford, S.C., Vaux, E.C., Cockman, M.E., Wykoff, C.C., Pugh, C.W., Maher, E.R., and Ratcliffe, P.J. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
49
-
-
0037837724
-
Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex
-
Maynard, M.A., Qi, H., Chung, J., Lee, E.H., Kondo, Y., Hara, S., Conaway, R.C., Conaway, J.W., and Ohh, M. (2003). Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. J. Biol. Chem. 278, 11032-11040.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11032-11040
-
-
Maynard, M.A.1
Qi, H.2
Chung, J.3
Lee, E.H.4
Kondo, Y.5
Hara, S.6
Conaway, R.C.7
Conaway, J.W.8
Ohh, M.9
-
50
-
-
0030587161
-
Regulation of inducible nitric oxide synthase expression in IFN-γ-treated murine macrophages cultured under hypoxic conditions
-
Melillo, G., Taylor, L.S., Brooks, A., Cox, G.W., and Varesio, L. (1996). Regulation of inducible nitric oxide synthase expression in IFN-γ-treated murine macrophages cultured under hypoxic conditions. J. Immunol. 157, 2638-2644.
-
(1996)
J. Immunol.
, vol.157
, pp. 2638-2644
-
-
Melillo, G.1
Taylor, L.S.2
Brooks, A.3
Cox, G.W.4
Varesio, L.5
-
51
-
-
0032104245
-
The extended protein kinase C superfamily
-
Mellor, H. and Parker, P.J. (1998). The extended protein kinase C superfamily. Biochem. J. 332, 281-292.
-
(1998)
Biochem. J.
, vol.332
, pp. 281-292
-
-
Mellor, H.1
Parker, P.J.2
-
52
-
-
0042469448
-
Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases
-
Metzen, E., Zhou, J., Jelkmann, W., Fandrey, J., and Brüne, B. (2003). Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases. Mol. Biol. Cell 14, 3470-3481.
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 3470-3481
-
-
Metzen, E.1
Zhou, J.2
Jelkmann, W.3
Fandrey, J.4
Brüne, B.5
-
53
-
-
0037144096
-
+ channels in smooth muscle cells by a mitochondrial redox sensor
-
+ channels in smooth muscle cells by a mitochondrial redox sensor. Circ. Res. 91, 478-486.
-
(2002)
Circ. Res.
, vol.91
, pp. 478-486
-
-
Michelakis, E.D.1
Rebeyka, I.2
Wu, X.3
Nsair, A.4
Thebaud, B.5
Hashimoto, K.6
Dyck, J.R.7
Haromy, A.8
Harry, G.9
Barr, A.10
Archer, S.L.11
-
54
-
-
0037081745
-
2 inhibitors
-
2 inhibitors. Biochem. Pharmacol. 63, 321-332.
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 321-332
-
-
Michiels, C.1
Renard, P.2
Bouaziz, N.3
Heck, N.4
Eliaers, F.5
Ninane, N.6
Quarck, R.7
Holvoet, P.8
Raes, M.9
-
56
-
-
0029060391
-
Protein kinase C and lipid signaling for sustained cellular responses
-
Nishizuka, Y. (1995). Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9, 484-496.
-
(1995)
FASEB J.
, vol.9
, pp. 484-496
-
-
Nishizuka, Y.1
-
57
-
-
0041464531
-
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1α and HIF-2α in prostate cancer cells
-
Palayoor, S.T., Tofilon, P.J., and Coleman, C.N. (2003). Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1α and HIF-2α in prostate cancer cells. Clin. Cancer Res. 9, 3150-3157.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 3150-3157
-
-
Palayoor, S.T.1
Tofilon, P.J.2
Coleman, C.N.3
-
58
-
-
33745779304
-
Regulation of HIF: Asparaginyl hydroxylation
-
Peet, D. and Linke, S. (2006). Regulation of HIF: asparaginyl hydroxylation. Novartis Found. Symp. 272, 37-49.
-
(2006)
Novartis Found. Symp.
, vol.272
, pp. 37-49
-
-
Peet, D.1
Linke, S.2
-
59
-
-
0036138369
-
Arachidonate release and c-fos expression in various models of hypoxia and hypoxia-hypoglycemia in retinoic acid differentiated neuroblastoma cells
-
Petroni, A., Papini, N., Blasevich, M., Rise, P., and Galli, C. (2002). Arachidonate release and c-fos expression in various models of hypoxia and hypoxia-hypoglycemia in retinoic acid differentiated neuroblastoma cells. Neurochem. Int. 40, 255-260.
-
(2002)
Neurochem. Int.
, vol.40
, pp. 255-260
-
-
Petroni, A.1
Papini, N.2
Blasevich, M.3
Rise, P.4
Galli, C.5
-
61
-
-
0034926047
-
Regulation of gene expression by nitric oxide
-
Pfeilschifter, J., Eberhardt, W., and Beck, K.F. (2001). Regulation of gene expression by nitric oxide. Pflüger's Arch. 442, 479-486.
-
(2001)
Pflüger's Arch.
, vol.442
, pp. 479-486
-
-
Pfeilschifter, J.1
Eberhardt, W.2
Beck, K.F.3
-
62
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: Role of the HIF system
-
Pugh, C.W. and Ratcliffe, P.J. (2003). Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9, 677-684.
-
(2003)
Nat. Med.
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
64
-
-
24144469144
-
Angiotensin II regulates vascular endothelial growth factor via hypoxia-inducible factor-1α induction and redox mechanisms in the kidney
-
Sanchez-Lopez, E., Lopez, A.F., Esteban, V., Yague, S., Egido, J., Ruiz-Ortega, M., and Alvarez-Arroyo, M.V. (2005). Angiotensin II regulates vascular endothelial growth factor via hypoxia-inducible factor-1α induction and redox mechanisms in the kidney. Antioxid. Redox Signal. 7, 1275-1284.
-
(2005)
Antioxid. Redox Signal.
, vol.7
, pp. 1275-1284
-
-
Sanchez-Lopez, E.1
Lopez, A.F.2
Esteban, V.3
Yague, S.4
Egido, J.5
Ruiz-Ortega, M.6
Alvarez-Arroyo, M.V.7
-
65
-
-
0031034814
-
Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells
-
Schmedtje, J.F. Jr., Ji, Y.S., Liu, W.L., DuBois, R.N., and Runge, M.S. (1997). Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem. 272, 601-608.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 601-608
-
-
Schmedtje Jr., J.F.1
Ji, Y.S.2
Liu, W.L.3
DuBois, R.N.4
Runge, M.S.5
-
67
-
-
0033233243
-
2 homeostasis by hypoxia-inducible factor
-
2 homeostasis by hypoxia-inducible factor. Annu. Rev. Cell Dev. Biol. 15, 551-578.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
68
-
-
0034663989
-
HIF-1 and human disease: One highly involved factor
-
Semenza, G.L. (2006). HIF-1 and human disease: one highly involved factor. Genes Dev. 14, 1983-1991.
-
(2006)
Genes Dev.
, vol.14
, pp. 1983-1991
-
-
Semenza, G.L.1
-
69
-
-
0029823459
-
Lipid mediator networks in cell signaling: Update and impact of cytokines
-
Serhan, C.N., Haeggstrom, J.Z., and Leslie, C.C. (1996). Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J. 10, 1147-1158.
-
(1996)
FASEB J.
, vol.10
, pp. 1147-1158
-
-
Serhan, C.N.1
Haeggstrom, J.Z.2
Leslie, C.C.3
-
70
-
-
0038115172
-
Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1α (HIF-1α). accumulation via redox-dependent mechanisms
-
Shatrov, V.A., Sumbayev, V.V., Zhou, J., and Brüne, B. (2003). Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1α (HIF-1α). accumulation via redox-dependent mechanisms. Blood 101, 4847-4849.
-
(2003)
Blood
, vol.101
, pp. 4847-4849
-
-
Shatrov, V.A.1
Sumbayev, V.V.2
Zhou, J.3
Brüne, B.4
-
72
-
-
0038218405
-
Sphingosine-1-phosphate: An enigmatic signaling lipid
-
Spiegel, S. and Milstien, S. (2003). Sphingosine-1-phosphate: an enigmatic signaling lipid. Nat. Rev. Mol. Cell Biol. 4, 397-407.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 397-407
-
-
Spiegel, S.1
Milstien, S.2
-
73
-
-
0037070223
-
Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway
-
Stiehl, D.P., Jelkmann, W., Wenger, R.H., and Hellwig-Burgel, T. (2002). Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway. FEBS Lett. 512, 157-162.
-
(2002)
FEBS Lett.
, vol.512
, pp. 157-162
-
-
Stiehl, D.P.1
Jelkmann, W.2
Wenger, R.H.3
Hellwig-Burgel, T.4
-
74
-
-
0032560504
-
Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
-
Sogawa, K., Numayama-Tsuruta, K., Ema, M., Abe, M., Abe, H., and Fujii-Kuriyama, Y. (1998). Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc. Natl. Acad. Sci. USA 95, 7368-7373.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7368-7373
-
-
Sogawa, K.1
Numayama-Tsuruta, K.2
Ema, M.3
Abe, M.4
Abe, H.5
Fujii-Kuriyama, Y.6
-
75
-
-
0347986779
-
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function
-
Takagi, S., Toio, H., Tomita, S., Sano, S., Itami, S., Hara, M., Inoue, S., Horie, K., Kondoh, G., Hosokawa, K., et al. (2003). Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. J. Clin. Invest. 112, 1372-1382.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1372-1382
-
-
Takagi, S.1
Toio, H.2
Tomita, S.3
Sano, S.4
Itami, S.5
Hara, M.6
Inoue, S.7
Horie, K.8
Kondoh, G.9
Hosokawa, K.10
-
76
-
-
0842308118
-
Role of diacylglycerol induced by hypoxia in the regulation of HIF-1α activity
-
Temes, E., Martin-Puig, S., Aragones, J., Jones, D.R., Olmos, G., merida, I., and Landazuri, M.O. (2004). Role of diacylglycerol induced by hypoxia in the regulation of HIF-1α activity. Biochem. Biophys. Res. Commun. 315, 44-50.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.315
, pp. 44-50
-
-
Temes, E.1
Martin-Puig, S.2
Aragones, J.3
Jones, D.R.4
Olmos, G.5
Merida, I.6
Landazuri, M.O.7
-
77
-
-
0034663561
-
Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts
-
Thornton, R.D., Lane, P., Borghaei, R.C., Pease, E.A., Caro, J., and Mochan, E. (2000). Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem. J. 350, 307-312.
-
(2000)
Biochem. J.
, vol.350
, pp. 307-312
-
-
Thornton, R.D.1
Lane, P.2
Borghaei, R.C.3
Pease, E.A.4
Caro, J.5
Mochan, E.6
-
78
-
-
0036938835
-
Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation
-
Yun, J.K. and Kester, M. (2002). Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. Arch. Biochem. Biophys. 408, 78-86.
-
(2002)
Arch. Biochem. Biophys.
, vol.408
, pp. 78-86
-
-
Yun, J.K.1
Kester, M.2
-
79
-
-
0030842898
-
Altered ceramide and sphingosine expression during the induction phase of ischemic acute renal failure
-
Zager, R.A., Iwata, M., Conrad, D.S., Burkhart, K.M., and Igarashi, Y. (1997). Altered ceramide and sphingosine expression during the induction phase of ischemic acute renal failure. Kidney Int. 52, 60-70.
-
(1997)
Kidney Int.
, vol.52
, pp. 60-70
-
-
Zager, R.A.1
Iwata, M.2
Conrad, D.S.3
Burkhart, K.M.4
Igarashi, Y.5
-
80
-
-
0032169214
-
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
-
Zelzer, E., Levy, Y., Kahana, C., Shilo, B.Z., Rubinstein, M., and Cohen, B. (1998). Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J. 17, 5085-5094.
-
(1998)
EMBO J.
, vol.17
, pp. 5085-5094
-
-
Zelzer, E.1
Levy, Y.2
Kahana, C.3
Shilo, B.Z.4
Rubinstein, M.5
Cohen, B.6
-
81
-
-
7044227910
-
NS398 reduces hypoxia-inducible factor (HIF)-1α and HIF-1 activity: Multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms
-
Zhong, H., Willard, M., and Simons, J. (2004). NS398 reduces hypoxia-inducible factor (HIF)-1α and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. Int. J. Cancer 112, 585-595.
-
(2004)
Int. J. Cancer
, vol.112
, pp. 585-595
-
-
Zhong, H.1
Willard, M.2
Simons, J.3
|