Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function

Journal of Clinical Investigation

Volumn 112, Issue 9, 2003, Pages 1372-1382

  Takagi, Satoshi ^a   Tojo, Hiromasa ^a   Tomita, Shuhei ^b   Sano, Shigetoshi ^a   Itami, Satoshi ^a   Hara, Mariko ^c   Inoue, Shintaro ^c   Horie, Kyoji ^a,d   Kondoh, Gen ^a   Hosokawa, Ko ^a   Gonzalez, Frank J ^e   Takeda, Junji ^a,d  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b RIKEN   (Japan)

^c KANEBO LTD   (Japan)

^d Res Inst Adv Sci Technol   (Japan)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DIHYDROCERAMIDE DESATURASE; DIHYDROCERAMIDE DESATURASE 1; DIHYDROCERAMIDE DESATURASE 2; ENZYME; HYPOXIA INDUCIBLE FACTOR 1BETA; ISOENZYME; PHYTOSPHINGOSINE; SPHINGANINE; SPHINGOSINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARNT GENE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DEHYDRATION; ENZYME DEFICIENCY; EPIDERMIS; GENE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE TARGETING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HYPOXIA; ION TRAP MASS SPECTROMETRY; KERATINOCYTE; MORTALITY; MOUSE; NEWBORN; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; SKIN PERMEABILITY; WATER LOSS;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BODY WATER; CERAMIDES; CHROMATOGRAPHY, THIN LAYER; DNA-BINDING PROTEINS; EPIDERMIS; KERATINOCYTES; MASS SPECTROMETRY; MICE; RECEPTORS, ARYL HYDROCARBON; SKIN; SPHINGOSINE; TRANSCRIPTION FACTORS;

EID: 0347986779     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200318513     Document Type: Article

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