Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase

Molecular Medicine

Volumn 7, Issue 6, 2001, Pages 406-417

  Liaudet, Lucas ^a,b   Yang, Zequan ^c   Al Affar, El Bachir ^d   Szabó, Csaba ^a,b  

^a INOTEK CORPORATION   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c University of Virginia   (United States)

^d UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZAMIDE; 3 NITROTYROSINE; 3-AMINOBENZAMIDE; 3-NITROTYROSINE; BENZAMIDE DERIVATIVE; DRUG DERIVATIVE; ENZYME INHIBITOR; INTERLEUKIN 10; INTERLEUKIN 12; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXIDASE; TISSUE EXTRACT; TUMOR NECROSIS FACTOR ALPHA; TYROSINE;

ANIMAL; ARTICLE; BLOOD; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; HEART INFARCTION PREVENTION; HEART MUSCLE; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; RAT; REPERFUSION INJURY; WISTAR RAT;

ANIMALS; BENZAMIDES; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; INTERLEUKIN-12; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NAD; PEROXIDASE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; TISSUE EXTRACTS; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 0035376102     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402187     Document Type: Article

References (48)

1. Le Rhun YL, Kirkland JB, Shah GM. (1998) Cellular responses to DNA damage in the absence of poly (ADP-ribose) polymerase. Biochem. Biophys. Res. Comm 245: 1-10.
2. Szabó C, Dawson VL. (1998) Role of poly (ADP-ribose) synthetase activation in inflammation and reperfusion injury. Trends. Pharmacol. Sci. 19: 287-298.
3. Szabó C, ed. (2000) Cell death, the role of PARP Boca Raton, FL: CRC Press.
4. Szabó C, Zingarelli B, O'Connor M, Salzman AL. (1996) DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl Acad Sci. U.S.A. 93: 1753-1758.
5. Szabó C, Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL. (1997) Endothelial dysfunction in endotoxic shock: importance of the activation of poly (ADP ribose) synthetase (PARS) by peroxynitrite. J. Clin. Invest. 100: 723-735.
6. Szabó C, Lim LH, Cuzzocrea S, et al. (1997) Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment. J. Exp. Med. 186: 1041-1049.
7. Szabó C, Virág L, Cuzzocrea S, et al. (1998) Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-ribose) synthetase. Proc. Natl. Acad. Sci. U.S.A. 95: 3867-3872.
8. Gilad E, Zingarelli B, Salzman AL, Szabó C. (1997) Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts in vitro. J. Mol. Cell. Cardiol. 29: 2585-2597.
9. Grupp IL, Jackson TM, Hake P, Grupp G, Szabó C. (1999) Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts. J. Mol. Cell. Cardiol. 31: 297-303.
10. Zingarelli B, Cuzzocrea S, Zsengeller Z, Salzman AL, Szabó C. (1997) Inhibition of poly (ADP ribose) synthetase protects against myocardial ischemia and reperfusion Injury. Cardiovasc. Res. 36: 205-212.
11. Zingarelli B, Salzman AL, Szabó C. (1998) Genetic disruption of poly (ADP ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia-reperfusion injury. Circ. Res. 83: 85-94.
12. Yang Z, Zingarelli B, Szabo C. (2000) Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury. Shock 13: 60-66.
13. Bhatnagar A. (1997) Contribution of ATP to oxidative stress-induced changes in action potential of isolated cardiac myocytes. Am. J. Physiol. 272: H1598-H1608.
14. Thiemermann C, Bowes J, Myint FP, Vane JR. (1997) Inhibition of the activity of poly(ADP ribose) synthase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc. Natl. Acad. Sci. U.S.A. 94: 679-683.
15. Walles T, Wang P, Pieper A, Snyder SS, Zweier J. (1998) Mice lacking poly(ADP-ribose) polymerase gene show attenuated cellular energy depletion and improved recovery of myocardial function following global ischemia. Circulation Suppl. 98: 1-260. (abstract).
16. Bowes J, Piper J, Thiemermann C. (1998) Inhibitors of the activity of poly (ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts. Br. J Pharmacol. 124: 1760-1766.
17. Bowes J, Ruetten H, Martorana PA, Stockhausen H, Thiemermann C. (1998) Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig. Eur. J. Pharmacol. 359: 143-150.
18. Docherty JC, Kuzio B, Silvester JA, Bowes J, Thiemermann C. (1999) An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart. Br. J. Pharmacol. 127: 1518-1524.
19. Pieper AA, Walles T, Wei G, Clements EE, Verma A, Snyder SH, Zweier JL. (2000) Myocardial postischemic injury is reduced by poly ADPripose polymerase-1 gene disruption. Mol. Med. 6: 271-282.
20. Yellon DM, Baxter GF, Garcia-Dorado D, Heusch G, Sumeray MS. (1998) Ischaemic preconditioning: present position and future directions. Cardiovasc. Res. 37: 21-33.
21. de Jonge R, Bradamante S, de Jong, JW. (1998) Cardioprotection by ischemic preconditioning. Role of adenosine and glycogen. Adv. Exp. Med. Biol. 431: 279-282.
22. Ferdinandy P, Szilvassy Z, Baxter GF. (1998) Adaptation to myocardial stress in disease states: is preconditioning a healthy heart phenomenon? Trends Pharmacol. Sci. 19: 223-229.
23. Miura T, Tsuchida A. (1999) Adenosine and preconditioning revisited. Clin Exp. Pharmacol. Physiol. 26: 92-99.
24. Edwards RJ, Marber MS. (1998) Myocardial preconditioning: mechanisms and man. Int J. Clin Pract. 52: 395-401.
25. Wang ZQ, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner EF. (1995) Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 9: 510-520.
26. Takano H, Manchikalapudi S, Tang XL, et al. (1998) Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits. Circulation 98: 441-449.
27. Haskó G, Szabó C, Németh ZH, Salzman AL, Vizi ES. (1998) Suppression of IL-12 production by phosphodiesterase inhibition in murine endotoxemia is IL-10 independent. Eur. J Immunol. 28: 468-472.
28. Shah GM, Poirier D, Duchaine C, et al. (1995) Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo. Anal. Biochem. 227: 1-13.
29. Liaudet L, Soriano FG, Szabo E, Virag L, Mabley JG, Salzman AL, Szabo C. (2000) Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase. Proc. Natl. Acad. Sci. U.S.A. 97: 10203-10208.
30. Oliver FJ, Menissier-de Murcia J, Nacci C, et al. (1999) Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J. 18: 4446-4454.
31. Soriano FG, Virág L, Jagtap P, et al. (2001) Diabetic endothelial dysfunction: the role of poly (ADP-ribose) polymerase activation. Nat Med. 7:108-113.
32. Zahradka P, Ebisuzaki K. (1982) A shuttle mechanism for DNA-protein interactions. The regulation of poly(ADP-ribose) polymerase. Eur. J. Biochem. 127: 579-585.
33. Vispe S, Yung TM, Ritchot J, Serizawa H, Satoh MS. (2000) A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage. Proc. Natl. Acad. Sci. U.S.A. 97: 9886-9891.
34. Lazzarino G, Raatikainen P, Nuutinen M, et al. (1994) Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery. Circulation 90: 291-297.
35. Kopacz M, Karwatowska-Prokopczuk E, Beresewicz A. (1993) Reperfusion arrhythmias and purine wash-out in isolated rat and rabbit heart. Effect of allopurinol, dimethylthiourea and calcium reduction. J Mol Cell. Cardiol. 25: 859-874.
36. Van Bilsen M, Van der Vusse GJ, Coumans WA, dc Groot MJ, Willemsen PH, Reneman RS. (1989) Degradation of adenine nucleotides in ischemic and reperfused rat heart. Am. J. Physiol. 257: H47-H54.
37. Virag L, Szabo C. (2000) Hypoxanthine and other purines inhibit the activation of poly(ADP-ribose) synthetase: implications for the pathophysiology of ischemia-reperfusion injury. Shock 13(suppl): 58 (abstract).
38. Virag L, Szabo C. (2001) Purines inhibit the activation of poly(ADP-ribose) synthetase: implications for the pathophysiology of ischemia-reperfusion injury. FASEB J. (in press).
39. Virag L, Scott GS, Cuzzocrea S, Marmer D, Salzman AL, Szabo C. (1998) Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation. Immunology 94: 345-355.
40. Ha HC, Snyder SH. (1999) Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc. Natl. Acad. Sci. U.S.A. 96: 13978-13982.
41. Spolarics Z, Stein DS, Garcia ZC. (1996) Endotoxin stimulates hydrogen peroxide detoxifying activity in rat hepatic endothelial cells. Hepatology 24: 691-696.
42. Omar HM, Rosenblum JK, Sanders RA, Watkins JB. (1998) Streptozotocin may provide protection against subsequent oxidative stress of endotoxin or Streptozotocin in rats. J. Biochem. Mol. Toxicol. 12: 143-149.
43. Kuratko CN. (1999) Iron increases manganese Superoxide dismutase activity in intestinal epithelial cells. Toxicol. Lett. 104: 151-158.
44. Csonka C, Pataki T, Kovacs P, Muller SL, Schroeter ML, Tosaki A, Blasig IE. (2000) Effects of oxidative stress on the expression of antioxidative defense enzymes in spontaneously hypertensive rat hearts. Free Radic. Biol. Med. 29: 612-619.
45. Kamisaki, Y, Wada K, Bian K, et al. (1998) An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc. Natl. Acad. Sci U.S.A. 95: 11584-11589.
46. Seligmann C, Kupatt C, Becker BF, Zahler S, Beblo S. (1998) Adenosine endogenously released during early reperfusion mitigates postischemic myocardial dysfunction by inhibiting platelet adhesion. J Cardiovasc Pharmacol. 32: 156-163.
47. Figueredo VM, Diamond I, Zhou HZ, Camacho SA. (1999) Chronic dipyridamole therapy produces sustained protection against cardiac ischemia-reperfusion injury. Am. J. Physiol. 277: H2091-H2097.
48. Xia Y, Zweier JL. (1995) Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J. Biol Chem. 270: 18797-18803.