메뉴 건너뛰기




Volumn 6, Issue 11, 2006, Pages 876-885

Integration of EGFR inhibitors with radiochemotherapy

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR;

EID: 33750357154     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1953     Document Type: Review
Times cited : (259)

References (137)
  • 1
    • 0018425119 scopus 로고
    • Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
    • Steel, G. G. & Peckham, M. J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int. J. Radiat. Onc. Biol. Phys. 5, 85-91 (1979).
    • (1979) Int. J. Radiat. Onc. Biol. Phys. , vol.5 , pp. 85-91
    • Steel, G.G.1    Peckham, M.J.2
  • 2
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effective relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou, T.-C. & Talalay, P. Quantitative analysis of dose-effective relationships: the combined effects of multiple drugs or enzyme inhibitors. Advances Enzyme Res. 22, 27-55 (1984).
    • (1984) Advances Enzyme Res. , vol.22 , pp. 27-55
    • Chou, T.-C.1    Talalay, P.2
  • 3
    • 0029954120 scopus 로고    scopus 로고
    • Treatment of cancer with radiation and drugs
    • Tannock, I. F. Treatment of cancer with radiation and drugs. J. Clin. Oncol. 14, 3156-3174 (1996).
    • (1996) J. Clin. Oncol. , vol.14 , pp. 3156-3174
    • Tannock, I.F.1
  • 4
    • 0034681783 scopus 로고    scopus 로고
    • Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer
    • Pignon, J. P. et al. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 355, 949-955 (2000).
    • (2000) Lancet , vol.355 , pp. 949-955
    • Pignon, J.P.1
  • 5
    • 0029778934 scopus 로고    scopus 로고
    • Improved survival in stage III non-small-cell lung cancer: Seven-year follow-up of cancer and leukemia group B (CALGB) 8433 trial
    • Dillman, R. O. et al. Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B (CALGB) 8433 trial. J. Natl Cancer Inst. 88, 1210-1215 (1996).
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 1210-1215
    • Dillman, R.O.1
  • 6
    • 24944463393 scopus 로고    scopus 로고
    • Optimal therapy for unresectable stage III non-small-cell lung cancer
    • Vokes, E. E. Optimal therapy for unresectable stage III non-small-cell lung cancer. J. Clin. Oncol. 23, 5853-5855 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5853-5855
    • Vokes, E.E.1
  • 7
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien, S. G. et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 348, 994-1004 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 994-1004
    • O'Brien, S.G.1
  • 8
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumours
    • Demetri, G. D. et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumours. N. Engl. J. Med. 347, 472-480 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 472-480
    • Demetri, G.D.1
  • 9
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian, H. et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N. Engl. J. Med. 346, 645-652 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 645-652
    • Kantarjian, H.1
  • 10
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Bonner, J. A. et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 354, 567-578 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 567-578
    • Bonner, J.A.1
  • 11
    • 0022395092 scopus 로고
    • The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies
    • Gullick, W. J. et al. The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies. Proc. R. Soc. Lond. B 226, 127-134 (1985).
    • (1985) Proc. R. Soc. Lond. B , vol.226 , pp. 127-134
    • Gullick, W.J.1
  • 12
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn, J. & Baselga, J. The EGF receptor family as targets for cancer therapy. Oncogene 19, 6550-6565 (2000).
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 13
    • 0028106163 scopus 로고
    • Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor
    • Ward, W. H. et al. Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor. Biochem. Pharmacol. 48, 659-666 (1994).
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 659-666
    • Ward, W.H.1
  • 14
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki, A. & Gazit, A. Tyrosine kinase inhibition: an approach to drug development. Science 267, 1782-1788 (1995).
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 15
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumour xenograft model
    • Goldstein, N. I., Prewett, M., Zuklys, K., Rockwell, P. & Mendelsohn, J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumour xenograft model. Clin. Cancer Res. 1, 1311-1318 (1995).
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1311-1318
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3    Rockwell, P.4    Mendelsohn, J.5
  • 16
    • 13144266690 scopus 로고    scopus 로고
    • Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor
    • Fry, D. W. et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc. Natl Acad. Sci. USA 95, 12022-12027 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12022-12027
    • Fry, D.W.1
  • 17
    • 0034068319 scopus 로고    scopus 로고
    • Antitumour effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello, F. et al. Antitumour effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin. Cancer Res. 6, 2053-2063 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2053-2063
    • Ciardiello, F.1
  • 18
    • 0141599428 scopus 로고    scopus 로고
    • Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
    • Stamos, J., Sliwkowski, M. X. & Eigenbrot, C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J. Biol. Chem. 277, 46265-46272 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 46265-46272
    • Stamos, J.1    Sliwkowski, M.X.2    Eigenbrot, C.3
  • 19
    • 0031054990 scopus 로고    scopus 로고
    • Epidermal growth factor receptor family and chemosensitization
    • Mendelsohn, J. & Fan, Z. Epidermal growth factor receptor family and chemosensitization. J. Natl Cancer Inst. 89, 341-343 (1997).
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 341-343
    • Mendelsohn, J.1    Fan, Z.2
  • 20
    • 0033966576 scopus 로고    scopus 로고
    • In vivo enhancement of tumour radioresponse by C225 antiepidermal growth factor receptor antibody
    • Milas, L. et al. In vivo enhancement of tumour radioresponse by C225 antiepidermal growth factor receptor antibody. Clin. Cancer Res. 6, 701-708 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 701-708
    • Milas, L.1
  • 21
    • 0035254521 scopus 로고    scopus 로고
    • Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
    • Harari, P. M. & Huang, S. M. Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation. Int. J. Rad. Oncol. Biol. Phys. 49, 427-433 (2001).
    • (2001) Int. J. Rad. Oncol. Biol. Phys. , vol.49 , pp. 427-433
    • Harari, P.M.1    Huang, S.M.2
  • 22
    • 0035409904 scopus 로고    scopus 로고
    • IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer
    • Herbst, R. S., Kim, E. S. & Harari, P. M. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer. Expert Opin. Biol. Ther. 1, 719-732 (2001).
    • (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 719-732
    • Herbst, R.S.1    Kim, E.S.2    Harari, P.M.3
  • 23
    • 0347928791 scopus 로고    scopus 로고
    • EGFR blockade with ZD1839 ('Iressa') potentiates the antitumour effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. Epidermal growth factor receptor
    • Solomon, B. et al. EGFR blockade with ZD1839 ('Iressa') potentiates the antitumour effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. Epidermal growth factor receptor. Int. J. Radiat. Oncol. Biol. Phys. 55, 713-723 (2003).
    • (2003) Int. J. Radiat. Oncol. Biol. Phys. , vol.55 , pp. 713-723
    • Solomon, B.1
  • 24
    • 11144298617 scopus 로고    scopus 로고
    • Anti-EGFR and radiotherapy
    • Milano, G. & Magne, N. Anti-EGFR and radiotherapy. Cancer Radiother. 8, 380-382 (2004).
    • (2004) Cancer Radiother. , vol.8 , pp. 380-382
    • Milano, G.1    Magne, N.2
  • 25
    • 0842304926 scopus 로고    scopus 로고
    • Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo
    • Nyati, M. K. et al. Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo. Clin. Cancer Res. 10, 691-700 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 691-700
    • Nyati, M.K.1
  • 26
    • 16844361931 scopus 로고    scopus 로고
    • New strategies to interfere with radiation response: 'Biomodulation' of radiation therapy
    • Deutsch, E., Kaliski, A., Maggiorella, L. & Bourhis, J. New strategies to interfere with radiation response: 'biomodulation' of radiation therapy. Cancer Radiother. 9, 69-76 (2005).
    • (2005) Cancer Radiother. , vol.9 , pp. 69-76
    • Deutsch, E.1    Kaliski, A.2    Maggiorella, L.3    Bourhis, J.4
  • 28
    • 3843116718 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer
    • Parra, H. S. et al. Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer. Br. J. Cancer 91, 208-212 (2004).
    • (2004) Br. J. Cancer , vol.91 , pp. 208-212
    • Parra, H.S.1
  • 29
    • 8644234228 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer
    • Han, S. W. et al. Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer. Int. J. Cancer 113, 109-115 (2005).
    • (2005) Int. J. Cancer , vol.113 , pp. 109-115
    • Han, S.W.1
  • 30
    • 0043132288 scopus 로고    scopus 로고
    • Gefitinib in pretreated non-small-cell lung cancer (NSCLC): Analysis of efficacy and correlation with HER2 and epidermal growth factor receptor expression in locally advanced or metastatic NSCLC
    • Cappuzzo, F. et al. Gefitinib in pretreated non-small-cell lung cancer (NSCLC): analysis of efficacy and correlation with HER2 and epidermal growth factor receptor expression in locally advanced or metastatic NSCLC. J. Clin. Oncol. 21, 2658-2663 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2658-2663
    • Cappuzzo, F.1
  • 31
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo, F. et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J. Natl Cancer Inst. 97, 643-655 (2005).
    • (2005) J. Natl Cancer Inst. , vol.97 , pp. 643-655
    • Cappuzzo, F.1
  • 32
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study
    • Hirsch, F. R. et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J. Clin. Oncol. 23, 6838-6845 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6838-6845
    • Hirsch, F.R.1
  • 33
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano, T. et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J. Clin. Oncol. 23, 6829-6837 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6829-6837
    • Takano, T.1
  • 34
    • 27244444360 scopus 로고    scopus 로고
    • Selecting patients for epidermal growth factor receptor inhibitor treatment: A FISH story or a tale of mutations?
    • Johnson, B. E. & Janne, P. A. Selecting patients for epidermal growth factor receptor inhibitor treatment: a FISH story or a tale of mutations? J. Clin. Oncol. 23, 6813-6816 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6813-6816
    • Johnson, B.E.1    Janne, P.A.2
  • 35
    • 0027225697 scopus 로고
    • Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas
    • Garcia de Palazzo, I. E. et al. Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas. Cancer Res. 53, 3217-3220 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 3217-3220
    • Garcia De Palazzo, I.E.1
  • 36
    • 0028800035 scopus 로고
    • Frequent expression of a mutant epidermal growth factor receptor in multiple human tumours
    • Moscatello, D. K. et al. Frequent expression of a mutant epidermal growth factor receptor in multiple human tumours. Cancer Res. 55, 5536-5539 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 5536-5539
    • Moscatello, D.K.1
  • 37
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff, I. K. et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 353, 2012-2024 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1
  • 38
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 39
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1
  • 40
    • 19844375720 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in non-small-cell lung cancer: Implications for treatment and tumour biology
    • Janne, P. A., Engelman, J. A. & Johnson, B. E. Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumour biology. J. Clin. Oncol. 23, 3227-3234 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3227-3234
    • Janne, P.A.1    Engelman, J.A.2    Johnson, B.E.3
  • 41
    • 33645101097 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in non-small cell lung cancer: A basic science discovery with immediate clinical impact
    • Dowell, J. E. Epidermal growth factor receptor mutations in non-small cell lung cancer: a basic science discovery with immediate clinical impact. Am. J. Med. Sci. 331, 139-149 (2006).
    • (2006) Am. J. Med. Sci. , vol.331 , pp. 139-149
    • Dowell, J.E.1
  • 42
    • 0024316128 scopus 로고
    • Enhancement of sensitivity of human squamous carcinoma cells to radiation by epidermal growth factor
    • Kwok, T. T. & Sutherland, R. M. Enhancement of sensitivity of human squamous carcinoma cells to radiation by epidermal growth factor. J. Natl Cancer Inst. 81, 1020-1024 (1989).
    • (1989) J. Natl Cancer Inst. , vol.81 , pp. 1020-1024
    • Kwok, T.T.1    Sutherland, R.M.2
  • 43
    • 0028339821 scopus 로고
    • The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities
    • Bonner, J. A., Maihle, N. J., Folven, B. R., Christianson, T. J. & Spain, K. The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities. Int. J. Radiat. Oncol. Biol. Phys. 29, 243-247 (1994).
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.29 , pp. 243-247
    • Bonner, J.A.1    Maihle, N.J.2    Folven, B.R.3    Christianson, T.J.4    Spain, K.5
  • 44
    • 0000091450 scopus 로고    scopus 로고
    • The effect of ionizing radiation on signal transduction: Antibodies to EGF receptor sensitize A431 cells to radiation
    • Balaban, N. et al. The effect of ionizing radiation on signal transduction: Antibodies to EGF receptor sensitize A431 cells to radiation. Biochim. Biophys. Acta 1314, 147-156 (1996).
    • (1996) Biochim. Biophys. Acta , vol.1314 , pp. 147-156
    • Balaban, N.1
  • 45
    • 0030803735 scopus 로고    scopus 로고
    • Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neck
    • Sheridan, M. T., O'Dwyer, T., Seymour, C. B. & Mothersill, C. E. Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neck. Radiat. Oncol. Investig. 5, 180-186 (1997).
    • (1997) Radiat. Oncol. Investig. , vol.5 , pp. 180-186
    • Sheridan, M.T.1    O'Dwyer, T.2    Seymour, C.B.3    Mothersill, C.E.4
  • 46
    • 0032719534 scopus 로고    scopus 로고
    • Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas
    • Akimoto, T. et al. Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clin. Cancer Res. 5, 2884-2890 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2884-2890
    • Akimoto, T.1
  • 47
    • 1242270605 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and tumour response to radiation: In vivo preclinical studies
    • Milas, L., Fan, Z., Andratschke, N. H. & Ang, K. K. Epidermal growth factor receptor and tumour response to radiation: in vivo preclinical studies. Int. J. Rad. Oncol. Biol. Phys. 58, 966-971 (2004).
    • (2004) Int. J. Rad. Oncol. Biol. Phys. , vol.58 , pp. 966-971
    • Milas, L.1    Fan, Z.2    Andratschke, N.H.3    Ang, K.K.4
  • 48
    • 0037115674 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
    • Ang, K. K. et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res. 62, 7350-7356 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 7350-7356
    • Ang, K.K.1
  • 49
    • 0029776415 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody 225 upregulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145
    • Peng, D. et al. Anti-epidermal growth factor receptor monoclonal antibody 225 upregulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res. 56, 3666-3669 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 3666-3669
    • Peng, D.1
  • 50
    • 0037374686 scopus 로고    scopus 로고
    • Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells
    • Di Gennaro, E. et al. Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells. J. Cell Physiol. 195, 139-150 (2003).
    • (2003) J. Cell Physiol. , vol.195 , pp. 139-150
    • Di Gennaro, E.1
  • 51
    • 0030042135 scopus 로고    scopus 로고
    • Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells
    • Schmidt-Ullrich, R. K., Valerie, K., Fogleman, P. B. & Walters, J. Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells. Radiat. Res. 145, 81-85 (1996).
    • (1996) Radiat. Res. , vol.145 , pp. 81-85
    • Schmidt-Ullrich, R.K.1    Valerie, K.2    Fogleman, P.B.3    Walters, J.4
  • 52
    • 0030772168 scopus 로고    scopus 로고
    • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
    • Schmidt-Ullrich, R. K. et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 15, 1191-1197 (1997).
    • (1997) Oncogene , vol.15 , pp. 1191-1197
    • Schmidt-Ullrich, R.K.1
  • 53
    • 0032815618 scopus 로고    scopus 로고
    • Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death
    • Dent, P. et al. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol. Biol. Cell 10, 2493-2506 (1999).
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2493-2506
    • Dent, P.1
  • 54
    • 0037030519 scopus 로고    scopus 로고
    • Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signalling in carcinoma cells
    • Contessa, J. N. et al. Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signalling in carcinoma cells. Oncogene 21, 4032-4041 (2002).
    • (2002) Oncogene , vol.21 , pp. 4032-4041
    • Contessa, J.N.1
  • 55
    • 24744449739 scopus 로고    scopus 로고
    • Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
    • Dittmann, K. et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J. Biol. Chem. 280, 31182-31189 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 31182-31189
    • Dittmann, K.1
  • 56
    • 0035868359 scopus 로고    scopus 로고
    • The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells
    • Bowers, G. et al. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. Oncogene 20, 1388-1397 (2001).
    • (2001) Oncogene , vol.20 , pp. 1388-1397
    • Bowers, G.1
  • 57
    • 4444230648 scopus 로고    scopus 로고
    • Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma
    • Hagan, M., Yacoub, A. & Dent, P. Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma. Clin. Cancer Res. 10, 5724-5731 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5724-5731
    • Hagan, M.1    Yacoub, A.2    Dent, P.3
  • 58
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
    • Huang, S. M., Bock, J. M. & Harari, P. M. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res. 59, 1935-1940 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 1935-1940
    • Huang, S.M.1    Bock, J.M.2    Harari, P.M.3
  • 59
    • 0034565927 scopus 로고    scopus 로고
    • Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor
    • Rao, G. S., Murray, S. & Ethier, S. P. Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor. Int. J. Rad. Oncol. Biol. Phys. 48, 1519-1528 (2000).
    • (2000) Int. J. Rad. Oncol. Biol. Phys. , vol.48 , pp. 1519-1528
    • Rao, G.S.1    Murray, S.2    Ethier, S.P.3
  • 60
    • 0034329308 scopus 로고    scopus 로고
    • Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers
    • Bonner, J. A. et al. Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers. J. Clin. Oncol. 18, 47S-53S (2000).
    • (2000) J. Clin. Oncol. , vol.18
    • Bonner, J.A.1
  • 61
    • 0033748391 scopus 로고    scopus 로고
    • Antitumour activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide
    • Bianco, C. et al. Antitumour activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide. Clin. Cancer Res. 6, 4343-4350 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4343-4350
    • Bianco, C.1
  • 62
    • 0242425890 scopus 로고    scopus 로고
    • Enhancement of tumour radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer
    • Shintani, S. et al. Enhancement of tumour radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer. Int. J. Cancer 107, 1030-1037 (2003).
    • (2003) Int. J. Cancer , vol.107 , pp. 1030-1037
    • Shintani, S.1
  • 63
    • 17344382185 scopus 로고    scopus 로고
    • Combined modality therapy of A431 human epidermoid cancer using anti-EGFr antibody C225 and radiation
    • Saleh, M. N. et al. Combined modality therapy of A431 human epidermoid cancer using anti-EGFr antibody C225 and radiation. Cancer Biother. Radiopharm. 14, 451-463 (1999).
    • (1999) Cancer Biother. Radiopharm. , vol.14 , pp. 451-463
    • Saleh, M.N.1
  • 64
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumour angiogenesis
    • Huang, S. M. & Harari, P. M. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumour angiogenesis. Clin. Cancer Res. 6, 2166-2174 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2166-2174
    • Huang, S.M.1
  • 65
    • 0033970141 scopus 로고    scopus 로고
    • Modulation of molecular targets to enhance radiation
    • Harari, P. M. & Huang, S. M. Modulation of molecular targets to enhance radiation. Clin. Cancer Res. 6, 323-325 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 323-325
    • Harari, P.M.1    Huang, S.M.2
  • 66
    • 0033574690 scopus 로고    scopus 로고
    • Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor
    • Li, J., Lin, M. L., Wiepz, G. J., Guadarrama, A. G. & Bertics, P. J. Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor. J. Biol. Chem. 274, 11209-11219 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 11209-11219
    • Li, J.1    Lin, M.L.2    Wiepz, G.J.3    Guadarrama, A.G.4    Bertics, P.J.5
  • 67
    • 2342557044 scopus 로고    scopus 로고
    • Targeted therapies for non-small-cell lung cancer: Biology, rationale, and preclinical results from a radiation oncology perspective
    • Raben, D., Helfrich, B. & Bunn, P. A. Targeted therapies for non-small-cell lung cancer: biology, rationale, and preclinical results from a radiation oncology perspective. Int. J. Rad. Oncol. Biol. Phys. 59, 27-38 (2004).
    • (2004) Int. J. Rad. Oncol. Biol. Phys. , vol.59 , pp. 27-38
    • Raben, D.1    Helfrich, B.2    Bunn, P.A.3
  • 68
    • 0035398021 scopus 로고    scopus 로고
    • Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
    • Robert, F. et al. Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J. Clin. Oncol. 19, 3234-3243 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3234-3243
    • Robert, F.1
  • 69
    • 5144229336 scopus 로고    scopus 로고
    • Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over single-agent receptor targeting
    • Matar, P. et al. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin. Cancer Res. 10, 6487-6501 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6487-6501
    • Matar, P.1
  • 70
    • 3442891161 scopus 로고    scopus 로고
    • Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
    • Huang, S., Armstrong, E. A., Benavente, S., Chinnaiyan, P. & Harari, P. M. Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res. 64, 5355-5362 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 5355-5362
    • Huang, S.1    Armstrong, E.A.2    Benavente, S.3    Chinnaiyan, P.4    Harari, P.M.5
  • 71
    • 0027290650 scopus 로고
    • Antitumour effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
    • Baselga, J. et al. Antitumour effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J. Natl Cancer Inst. 85, 1327-1333 (1993).
    • (1993) J. Natl Cancer Inst. , vol.85 , pp. 1327-1333
    • Baselga, J.1
  • 72
    • 0027428571 scopus 로고
    • Antitumour effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
    • Fan, Z., Baselga, J., Masui, H. & Mendelsohn, J. Antitumour effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res. 53, 4637-4642 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 4637-4642
    • Fan, Z.1    Baselga, J.2    Masui, H.3    Mendelsohn, J.4
  • 73
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumour xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    • Sirotnak, F. M., Zakowski, M. F., Miller, V. A., Scher, H. I. & Kris, M. G. Efficacy of cytotoxic agents against human tumour xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin. Cancer Res. 6, 4885-4892 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3    Scher, H.I.4    Kris, M.G.5
  • 74
    • 0034629485 scopus 로고    scopus 로고
    • Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27 (KIP1) independent of MAPK activity
    • Busse, D. et al Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27 (KIP1) independent of MAPK activity. J. Biol. Chem. 275, 6987-6995 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 6987-6995
    • Busse, D.1
  • 75
    • 0029670014 scopus 로고    scopus 로고
    • Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
    • Wu, X. et al. Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 12, 1397-1403 (1996).
    • (1996) Oncogene , vol.12 , pp. 1397-1403
    • Wu, X.1
  • 76
    • 30444445564 scopus 로고    scopus 로고
    • Sequence-dependent antiproliferative effects of cytotoxic drugs and epidermal growth factor receptor inhibitors
    • Morelli, M. P. et al. Sequence-dependent antiproliferative effects of cytotoxic drugs and epidermal growth factor receptor inhibitors. Ann. Oncol. 16 (Suppl. 4), iv61-iv68 (2005).
    • (2005) Ann. Oncol. , vol.16 , Issue.SUPPL. 4
    • Morelli, M.P.1
  • 77
    • 31544464043 scopus 로고    scopus 로고
    • Synergistic effects of gemcitabine and gefitinib in the treatment of head and neck carcinoma
    • Chun, P. Y. et al. Synergistic effects of gemcitabine and gefitinib in the treatment of head and neck carcinoma. Cancer Res. 66, 981-988 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 981-988
    • Chun, P.Y.1
  • 78
    • 2942560684 scopus 로고    scopus 로고
    • The schedule-dependent enhanced cytotoxic activity of 7-ethyl-10-hydroxy-camptothecin (SN-38) in combination with Gefitinib (Iressa, ZD1839)
    • Azzariti, A., Xu, J. M., Porcelli, L. & Paradiso, A. The schedule-dependent enhanced cytotoxic activity of 7-ethyl-10-hydroxy- camptothecin (SN-38) in combination with Gefitinib (Iressa, ZD1839). Biochem. Pharmacol. 68, 135-144 (2004).
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 135-144
    • Azzariti, A.1    Xu, J.M.2    Porcelli, L.3    Paradiso, A.4
  • 79
    • 0142071058 scopus 로고    scopus 로고
    • Characterization of sequence-dependent synergy between ZD1839 ('Iressa') and oxaliplatin
    • Xu, J. M. et al. Characterization of sequence-dependent synergy between ZD1839 ('Iressa') and oxaliplatin. Biochem. Pharmacol. 66, 551-563 (2003).
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 551-563
    • Xu, J.M.1
  • 80
    • 0037069928 scopus 로고    scopus 로고
    • Cisplatin-induced activation of the EGF receptor
    • Benhar, M., Engelberg, D. & Levitzki, A. Cisplatin-induced activation of the EGF receptor. Oncogene 21, 8723-8731 (2002).
    • (2002) Oncogene , vol.21 , pp. 8723-8731
    • Benhar, M.1    Engelberg, D.2    Levitzki, A.3
  • 81
    • 27144471067 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy
    • Van Schaeybroeck, S. et al. Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin. Cancer Res. 11, 7480-7489 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7480-7489
    • Van Schaeybroeck, S.1
  • 82
    • 0842268375 scopus 로고    scopus 로고
    • ZD1839 modulates paclitaxel response in renal cancer by blocking paclitaxel-induced activation of the epidermal growth factor receptor-extracellular signal-regulated kinase pathway
    • Sumitomo, M. et al. ZD1839 modulates paclitaxel response in renal cancer by blocking paclitaxel-induced activation of the epidermal growth factor receptor-extracellular signal-regulated kinase pathway. Clin. Cancer Res. 10, 794-801 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 794-801
    • Sumitomo, M.1
  • 83
    • 16844367822 scopus 로고    scopus 로고
    • Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells
    • Abdelmohsen, K. et al. Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells. Biol. Chem. 386, 217-223 (2005).
    • (2005) Biol. Chem. , vol.386 , pp. 217-223
    • Abdelmohsen, K.1
  • 84
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich, A. & Schlessinger, J. Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212 (1990).
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 85
    • 33750290993 scopus 로고    scopus 로고
    • EGFR degradation: A novel mechanism of gemcitabine-induced cell death in head and neck cancer cell lines
    • Baltimore
    • Feng, F. Y. et al. EGFR degradation: a novel mechanism of gemcitabine-induced cell death in head and neck cancer cell lines. In 14th SPORE investigators' workshop 154 (Baltimore, 2006).
    • (2006) 14th SPORE Investigators' Workshop , pp. 154
    • Feng, F.Y.1
  • 86
    • 5144220297 scopus 로고    scopus 로고
    • Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839)
    • Friedmann, B., Caplin, M., Hartley, J. A. & Hochhauser, D. Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839). Clin. Cancer Res. 10, 6476-6486 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6476-6486
    • Friedmann, B.1    Caplin, M.2    Hartley, J.A.3    Hochhauser, D.4
  • 87
    • 33644987412 scopus 로고    scopus 로고
    • Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment
    • Friedmann, B. J. et al. Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment. Mol. Cancer Ther. 5, 209-218 (2006).
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 209-218
    • Friedmann, B.J.1
  • 88
    • 0041976904 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the interaction between ZD1839 ('Iressa') and cisplatin/5-fluorouracil
    • Magne, N. et al. Molecular mechanisms underlying the interaction between ZD1839 ('Iressa') and cisplatin/5-fluorouracil. Br. J. Cancer 89, 585-592 (2003).
    • (2003) Br. J. Cancer , vol.89 , pp. 585-592
    • Magne, N.1
  • 89
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
    • Giaccone, G. et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J. Clin. Oncol. 22, 777-784 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 777-784
    • Giaccone, G.1
  • 90
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
    • Herbst, R. S. et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J. Clin. Oncol. 22, 785-794 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 785-794
    • Herbst, R.S.1
  • 91
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst, R. S. et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J. Clin. Oncol. 23, 5892-5899 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5892-5899
    • Herbst, R.S.1
  • 92
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
    • Burtness, B., Goldwasser, M. A., Flood, W., Mattar, B. & Forastiere, A. A. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J. Clin. Oncol. 23, 8646-8654 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Forastiere, A.A.5
  • 93
    • 28944454332 scopus 로고    scopus 로고
    • Brief communication: A new combination in the treatment of advanced pancreatic cancer
    • Moore, M. J. Brief communication: a new combination in the treatment of advanced pancreatic cancer. Semin. Oncol. 32, 5-6 (2005).
    • (2005) Semin. Oncol. , vol.32 , pp. 5-6
    • Moore, M.J.1
  • 94
    • 27644460508 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group [NCIC-CTG]
    • Moore, M. J. et al. Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group [NCIC-CTG]. J. Clin. Oncol. 23, 1S-1S (2005).
    • (2005) J. Clin. Oncol. , vol.23
    • Moore, M.J.1
  • 95
    • 22044453790 scopus 로고    scopus 로고
    • Erlotinib in lung cancer- molecular and clinical predictors of outcome
    • Tsao, M. S. et al. Erlotinib in lung cancer- molecular and clinical predictors of outcome. N. Engl. J. Med. 353, 133-144 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 133-144
    • Tsao, M.S.1
  • 96
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colourectal cancer patients with tumours that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung, K. Y. et al. Cetuximab shows activity in colourectal cancer patients with tumours that do not express the epidermal growth factor receptor by immunohistochemistry. J. Clin. Oncol. 23, 1803-1810 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1803-1810
    • Chung, K.Y.1
  • 97
    • 4143113738 scopus 로고    scopus 로고
    • Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group)
    • Elie, C. et al. Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group). Br. J. Cancer 91, 470-475 (2004).
    • (2004) Br. J. Cancer , vol.91 , pp. 470-475
    • Elie, C.1
  • 98
    • 26944467607 scopus 로고    scopus 로고
    • The management of skin reactions in cancer patients receiving epidermal growth factor receptor targeted therapies
    • Segaert, S. et al. The management of skin reactions in cancer patients receiving epidermal growth factor receptor targeted therapies. J. Dtsch Dermatol. Ges. 3, 599-606 (2005).
    • (2005) J. Dtsch. Dermatol. Ges. , vol.3 , pp. 599-606
    • Segaert, S.1
  • 99
    • 1542503756 scopus 로고    scopus 로고
    • Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer: How do we go from INTACT to impact?
    • Baselga, J. Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer: How do we go from INTACT to impact? J. Clin. Oncol. 22, 759-761 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 759-761
    • Baselga, J.1
  • 100
    • 4143149763 scopus 로고    scopus 로고
    • Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor
    • Tan, A. R. et al. Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor. J. Clin. Oncol. 22, 3080-3090 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 3080-3090
    • Tan, A.R.1
  • 101
    • 30644463008 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dimerization status determines skin toxicity to HER-kinase targeted therapies
    • Laux, I., Jain, A., Singh, S. & Agus, D. B. Epidermal growth factor receptor dimerization status determines skin toxicity to HER-kinase targeted therapies. Br. J. Cancer 94, 85-92 (2006).
    • (2006) Br. J. Cancer , vol.94 , pp. 85-92
    • Laux, I.1    Jain, A.2    Singh, S.3    Agus, D.B.4
  • 103
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
    • Wendel, H. G. et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428, 332-337 (2004).
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.G.1
  • 105
    • 0035879832 scopus 로고    scopus 로고
    • EGF receptor-ERK pathway is the major signalling pathway that mediates upregulation of aldose reductase expression under oxidative stress
    • Nishinaka, T. & Yabe-Nishimura, C. EGF receptor-ERK pathway is the major signalling pathway that mediates upregulation of aldose reductase expression under oxidative stress. Free Radic. Biol. Med. 31, 205-216 (2001).
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 205-216
    • Nishinaka, T.1    Yabe-Nishimura, C.2
  • 106
    • 10344258041 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase cascade to treat cancer
    • Sebolt-Leopold, J. S. & Herrera, R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nature Rev. Cancer 4, 937-947 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 937-947
    • Sebolt-Leopold, J.S.1    Herrera, R.2
  • 107
    • 31144470222 scopus 로고    scopus 로고
    • PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors
    • Oliva, J. L., Griner, E. M. & Kazanietz, M. G. PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. Growth Factors 23, 245-252 (2005).
    • (2005) Growth Factors , vol.23 , pp. 245-252
    • Oliva, J.L.1    Griner, E.M.2    Kazanietz, M.G.3
  • 108
    • 0037013143 scopus 로고    scopus 로고
    • The conformational plasticity of protein kinases
    • Huse, M. & Kuriyan, J. The conformational plasticity of protein kinases. Cell 109, 275-282 (2002).
    • (2002) Cell , vol.109 , pp. 275-282
    • Huse, M.1    Kuriyan, J.2
  • 109
    • 0021832622 scopus 로고
    • Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase
    • Russo, M. W., Lukas, T. J., Cohen, S. & Staros, J. V. Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase. J. Biol. Chem. 260, 5205-5208 (1985).
    • (1985) J. Biol. Chem. , vol.260 , pp. 5205-5208
    • Russo, M.W.1    Lukas, T.J.2    Cohen, S.3    Staros, J.V.4
  • 110
    • 0022447485 scopus 로고
    • Antibodies to the ATP-binding site of the human epidermal growth factor (EGF) receptor as specific inhibitors of EGF-stimulated protein-tyrosine kinase activity
    • Gullick, W. J., Downward, J., Foulkes, J. G. & Waterfield, M. D. Antibodies to the ATP-binding site of the human epidermal growth factor (EGF) receptor as specific inhibitors of EGF-stimulated protein-tyrosine kinase activity. Eur. J. Biochem. 158, 245-253 (1986).
    • (1986) Eur. J. Biochem. , vol.158 , pp. 245-253
    • Gullick, W.J.1    Downward, J.2    Foulkes, J.G.3    Waterfield, M.D.4
  • 111
    • 0033583220 scopus 로고    scopus 로고
    • C-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function
    • Biscardi, J. S. et al. c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J. Biol. Chem. 274, 8335-8343 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 8335-8343
    • Biscardi, J.S.1
  • 112
    • 4744342856 scopus 로고    scopus 로고
    • Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation
    • Grovdal, L. M., Stang, E., Sorkin, A. & Madshus, I. H. Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation. Exp. Cell Res. 300, 388-395 (2004).
    • (2004) Exp. Cell Res. , vol.300 , pp. 388-395
    • Grovdal, L.M.1    Stang, E.2    Sorkin, A.3    Madshus, I.H.4
  • 113
    • 0027153103 scopus 로고
    • Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
    • Buday, L. & Downward, J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73, 611-620 (1993).
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday, L.1    Downward, J.2
  • 114
    • 0032544418 scopus 로고    scopus 로고
    • Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signalling
    • Keilhack, H. et al. Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signalling. J. Biol. Chem. 273, 24839-24846 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 24839-24846
    • Keilhack, H.1
  • 115
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi, S. et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 352, 786-792 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 786-792
    • Kobayashi, S.1
  • 116
    • 30944434263 scopus 로고    scopus 로고
    • Gefitinib response of erlotinib-refractory lung cancer involving meninges - Role of EGFR mutation
    • Choong, N. W. et al. Gefitinib response of erlotinib-refractory lung cancer involving meninges-role of EGFR mutation. Nature Clin. Pract. Oncol. 3, 50-57 (2006).
    • (2006) Nature Clin. Pract. Oncol. , vol.3 , pp. 50-57
    • Choong, N.W.1
  • 117
    • 28444455958 scopus 로고    scopus 로고
    • Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
    • Bell, D. W. et al. Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR. Nature Genet. 37, 1315-1316 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 1315-1316
    • Bell, D.W.1
  • 118
    • 28444453967 scopus 로고    scopus 로고
    • Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity
    • Dittmann, K., Mayer, C. & Rodemann, H. P. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother. Oncol. 76, 157-161 (2005).
    • (2005) Radiother. Oncol. , vol.76 , pp. 157-161
    • Dittmann, K.1    Mayer, C.2    Rodemann, H.P.3
  • 119
    • 28844486282 scopus 로고    scopus 로고
    • Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis
    • Boerner, J. L., Biscardi, J. S., Silva, C. M. & Parsons, S. J. Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis. Mol. Carcinog. 44, 262-273 (2005).
    • (2005) Mol. Carcinog. , vol.44 , pp. 262-273
    • Boerner, J.L.1    Biscardi, J.S.2    Silva, C.M.3    Parsons, S.J.4
  • 120
    • 3543025709 scopus 로고    scopus 로고
    • Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II
    • Boerner, J. L., Demory, M. L., Silva, C. & Parsons, S. J. Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II. Mol. Cell Biol. 24, 7059-7071 (2004).
    • (2004) Mol. Cell Biol. , vol.24 , pp. 7059-7071
    • Boerner, J.L.1    Demory, M.L.2    Silva, C.3    Parsons, S.J.4
  • 122
    • 0036667102 scopus 로고    scopus 로고
    • Cetuximab (Imclone/Merck/ Bristol-Myers Squibb)
    • Kies, M. S. & Harari, P. M. Cetuximab (Imclone/Merck/ Bristol-Myers Squibb). Curr. Opin. Investig. Drugs 3, 1092-1100 (2002).
    • (2002) Curr. Opin. Investig. Drugs , vol.3 , pp. 1092-1100
    • Kies, M.S.1    Harari, P.M.2
  • 123
    • 4143050397 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer
    • Rowinsky, E. K. et al. Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer. J. Clin. Oncol. 22, 3003-3015 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 3003-3015
    • Rowinsky, E.K.1
  • 124
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • Yang, X. D., Jia, X. C., Corvalan, J. R., Wang, P. & Davis, C. G. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 38, 17-23 (2001).
    • (2001) Crit. Rev. Oncol. Hematol. , vol.38 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3    Wang, P.4    Davis, C.G.5
  • 125
    • 0142154205 scopus 로고    scopus 로고
    • Technology evaluation: ABX-EGF, Abgenix/Amgen
    • Ranson, M. Technology evaluation: ABX-EGF, Abgenix/Amgen. Curr. Opin. Mol. Ther. 5, 541-546 (2003).
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 541-546
    • Ranson, M.1
  • 126
    • 1542344622 scopus 로고    scopus 로고
    • Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumours that express the epidermal growth factor receptor
    • Vanhoefer, U. et al. Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumours that express the epidermal growth factor receptor. J. Clin. Oncol. 22, 175-184 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 175-184
    • Vanhoefer, U.1
  • 127
    • 33646870539 scopus 로고    scopus 로고
    • A phase I study of the humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody EMD 72000 (matuzumab) in combination with paclitaxel in patients with EGFR-positive advanced non-small-cell lung cancer (NSCLC)
    • Kollmannsberger, C. et al. A phase I study of the humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody EMD 72000 (matuzumab) in combination with paclitaxel in patients with EGFR-positive advanced non-small-cell lung cancer (NSCLC). Ann. Oncol. (2006).
    • (2006) Ann. Oncol.
    • Kollmannsberger, C.1
  • 128
    • 8944263458 scopus 로고    scopus 로고
    • Phase 1 trial and tumour localization of the anti-EGFR monoclonal antibody ICR62 in head and neck or lung cancer
    • Modjtahedi, H. et al. Phase 1 trial and tumour localization of the anti-EGFR monoclonal antibody ICR62 in head and neck or lung cancer. Br. J. Cancer 73, 228-235 (1996).
    • (1996) Br. J. Cancer , vol.73 , pp. 228-235
    • Modjtahedi, H.1
  • 129
    • 0037673681 scopus 로고    scopus 로고
    • Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumours
    • Nakagawa, K. et al. Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumours. Ann. Oncol. 14, 922-930 (2003).
    • (2003) Ann. Oncol. , vol.14 , pp. 922-930
    • Nakagawa, K.1
  • 131
    • 26444610104 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hoekstra, R. et al. Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. Clin. Cancer Res. 11, 6908-6915 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6908-6915
    • Hoekstra, R.1
  • 132
    • 21044439024 scopus 로고    scopus 로고
    • Phase 1 clinical and pharmacokinetics evaluation of oral CI-1033 in patients with refractory cancer
    • Nemunaitis, J. et al. Phase 1 clinical and pharmacokinetics evaluation of oral CI-1033 in patients with refractory cancer. Clin. Cancer Res. 11, 3846-3853 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 3846-3853
    • Nemunaitis, J.1
  • 133
    • 8444221534 scopus 로고    scopus 로고
    • Administration of CI-1033, an irreversible pan-erbB tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: A phase I pharmacokinetic and food effect study
    • Calvo, E. et al. Administration of CI-1033, an irreversible pan-erbB tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase I pharmacokinetic and food effect study. Clin. Cancer Res. 10, 7112-7120 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 7112-7120
    • Calvo, E.1
  • 134
    • 24944486001 scopus 로고    scopus 로고
    • Multicenter, randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer
    • Campos, S. et al. Multicenter, randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer. J. Clin. Oncol. 23, 5597-5604 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5597-5604
    • Campos, S.1
  • 135
    • 0141607013 scopus 로고    scopus 로고
    • EKB-569, an irreversible inhibitor of the epidermal growth factor recepton: Phase 1 trial results in patients with advanced solid tumours
    • Erlichman, C. et al. EKB-569, an irreversible inhibitor of the epidermal growth factor recepton: Phase 1 trial results in patients with advanced solid tumours. Eur. J. Cancer 38, S64-S64 (2002).
    • (2002) Eur. J. Cancer , vol.38
    • Erlichman, C.1
  • 136
    • 33144464795 scopus 로고    scopus 로고
    • EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib
    • Yoshimura, N. et al. EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer 51, 363-368 (2006).
    • (2006) Lung Cancer , vol.51 , pp. 363-368
    • Yoshimura, N.1
  • 137
    • 23944476155 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
    • Burris, H. A., 3rd et al. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol. 23, 5305-5313 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5305-5313
    • Burris III, H.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.