Treatment of cancer with radiation and drugs

Journal of Clinical Oncology

Volumn 14, Issue 12, 1996, Pages 3156-3174

  Tannock, I F ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CARMUSTINE; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; HYDROXYUREA; MERCAPTOPURINE; METHOTREXATE; METHYLPREDNISOLONE; MISONIDAZOLE; MITOLACTOL; MITOMYCIN; PROCARBAZINE; RADIOSENSITIZING AGENT; SEMUSTINE; VINBLASTINE; VINCRISTINE; VINDESINE;

ANTINEOPLASTIC ACTIVITY; BLADDER CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL KILLING; CELL PROLIFERATION; CLINICAL TRIAL; DRUG RESISTANCE; GLIOBLASTOMA; HEAD AND NECK CANCER; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG NON SMALL CELL CANCER; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; RECTUM CANCER; REVIEW;

EID: 0029954120     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1996.14.12.3156     Document Type: Review

References (156)

1. Steel GG: The search for therapeutic gain in the combination of radiotherapy and chemotherapy. Radiother Oncol 11:31-53, 1988
2. Early Breast Cancer Trialists' Collaborative Group: Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomized trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet 339:1-15, 71-85, 1992
3. Steel GG, Peckham MJ: Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity. Int J Radiat Oncol Biol Phys 5:85-91, 1979
4. Selby P, Buick RN, Tannock I: A critical appraisal of the "human tumor stem-cell assay." N Engl J Med 308:129-134, 1983
5. Hedley D, Hallaban AR, Tripp EH: Flow cytometric measure- ment of glutathione content of human cancer biopsies. Br J Cancer 61:65-68, 1990
6. Teicher BA, Herman TS, Holden SA, et al: Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 247:1457-1461, 1990
7. Kobayashi H, Man S, Graham CH, et al: Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc Natl Acad Sci USA 90:3294-3298, 1993
8. Overgaard J, Sand Hansen J, Overgaard M, et al: Nimorazole as a hypoxic radiosensitizer in the treatment of supraglottic larynx and pharynx carcinoma. J Cancer Res Clin Oncol 116:509, 1990 (suppl 1)
9. Lee DJ, Cosmatos D, Marcial V, et al: Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole (SR-2508) with radiotherapy alone for locally advanced head and neck carcinomas. Int J Radiat Oncol Biol Phys 32:567-576, 1995
10. Rauth AM, Mohindra JK, Tannock IF: Activity of mitomycin-C for aerobic and hypoxic cells in vitro and in vivo. Cancer Res 43:4154-4158, 1983
11. Brown JM: SR 4233 (Tirapazamine): A new anticancer drug exploiting hypoxia in solid tumors. Br J Cancer 67:1163-1170, 1993
12. Brown JM, Koong A: Therapeutic advantage of hypoxic cells in tumors: A theoretical study. J Natl Cancer Inst 83:178-185, 1991
13. Wike-Hooley JL, Haveman J, Reinhold JS: The relevance of tumor pH to the treatment of malignant disease. Radiother Oncol 2:343-366, 1984
14. Tannock IF, Rotin D: Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res 49:4373-4384, 1989
15. Vaupel P, Kallinowski F, Okonieff P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res 49:6449-6465, 1989
16. Withers HR, Taylor JMF, Maciejewski B: The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 27:131-146, 1988
17. Tannock IF: Combined modality treatment with radiotherapy and chemotherapy. Radiother Oncol 16:83-101, 1989
18. Begg AC, McNally NJ, Schrieve DC, et al: A method to measure the duration of DNA synthesis and the potential doubling time from a single sample. Cytometry 6:620-626, 1985
19. Begg AC, Hofland I, Moonen L, et al: The predictive value of cell kinetic measurements in a European trial of accelerated fractionation in advanced head and neck tumors: An interim report. Int J Radiat Oncol Biol Phys 19:1449-1453, 1990
20. McMillan TJ, Hart IR: Enhanced experimental metastatic capacity of a murine melanoma following pre-treatment with anticancer drugs. Clin Exp Metastasis 4:285-292, 1986
21. Van Putten LM, Kram LKJ, van Dierendonck HMC, et al: Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection. Int J Cancer 15:588-595, 1975
22. Brown JM, Parker ET: Host treatments affecting artificial pulmonary metastases: Interpretation of loss of radioactivity labelled cells from lungs. Br J Cancer 40:677-688, 1979
23. Nicholson GL, Custead SE: Effects of chemotherapeutic drugs on platelet and metastatic tumor cell-endothelial cell interactions as a model for assessing vascular endothelial integrity. Cancer Res 45:331-336, 1985
24. Amman K, Amato D, Wood W, et al: Selection bias in clinical trials. J Clin Oncol 3:1142-1147, 1985
25. Davis S, Wright PW, Schulman SF, et al: Participants in prospective, randomized clinical trials for resected non-small cell lung cancer have improved survival compared with non-participants in such trials. Cancer 56:1710-1718, 1985
26. Bush RS: Malignancies of the Ovary, Uterus and Cervix. London, England, Edward Arnold, 1979
27. Feinstein AR, Sosin DM, Wells CK: The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. N Engl J Med 312:1604-1608, 1985
28. Anderson JR, Cain KC, Gelber RD: Analysis of survival by tumor response. J Clin Oncol 1:710-719, 1983
29. Simes RJ: Publication bias: The case for an international registry of clinical trials. J Clin Oncol 4:1529-1541, 1986
30. Begg CB, Berlin JA: Publication bias and dissemination of clinical research. J Natl Cancer Inst 81:107-115, 1989
31. DeBellefeuille C, Morrison CA, Tannock IF: The fate of abstracts submitted to a cancer meeting: Factors which influence presentation and subsequent publication. Ann Oncol 3:187-191, 1992
32. Hellman S, Hellman DS: Of mice but not men. Problems of the randomized clinical trial. N Engl J Med 324:1585-1589, 1991
33. Segelov E, Tattersall MHN, Coates AS: Redressing the balance - The ethics of not entering an eligible patient on a randomized clinical trial. Ann Oncol 3:103-105, 1992
34. Freiman JA, Chalmers TC, Smith H Jr, et al: The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" results. N Engl J Med 299:690-694, 1978
35. Staquet MJ, Rozencweig M, Von Hoff DD, et al: The delta and epsilon errors in the assessment of cancer clinical trials. Cancer Treat Rep 63:1917-1921, 1979
36. Tannock IF: False-positive results in clinical trials: Multiple significance tests and the problem of unreported comparisons. J Natl Cancer Inst 88:206-207, 1996
37. Yarnold JR, Hoskin PJ, Powel SN: Study design in the evaluation of combined radiotherapy plus chemotherapy. Eur J Cancer 26:773-775, 1990
38. Stewart LA, Parmar MKB: Meta-analysis of the literature or of individual patient data: Is there a difference? Lancet 341:418-422, 1993
39. Walker MD, Alexander E, Hunt WE, et al: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. J Neurosurg 49:333-343, 1978
40. Walker MD, Green SB, Byar DP, et al: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303:1323-1329, 1980
41. Nelson F, Diener-West M, Horton J, et al: Combined modality approach to treatment of malignant gliomas - Re-evaluation of RTOG 7401/ECOG 1374 with long-term follow-up. NCI Monogr 6:279-284, 1988
42. Green SB, Byar DP, Walker MD, et al: Comparisons of carmustine, procarbazine and high-dose methylprednisone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Treat Rep 67:121-132, 1983
43. EORTC Brain Tumor Group: Cisplatin does not enhance the effect of radiation therapy in malignant gliomas. Eur J Cancer 27:568-571, 1991
44. Hildebrand J, Sahmond T, Migrolet F, et al: Adjuvant therapy with dibromodulcitol and BCNU increases survival of adults with malignant gliomas. Neurology 44:1479-1483, 1994
45. Halperin EC, Herndon J, Schold SC Jr, et al: A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. Int J Radiat Oncol Biol Phys 34:793-802, 1996
46. Perry JR: Adjuvant chemotherapy for malignant glioma: An analysis of methodology and outcome data from clinical trials. Neurology 45:810S, 1995 (suppl 4)
47. Fine HA, Dear KBG, Loeffler JS, et al: Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71:2585-2597, 1993
48. Vokes EE, Weichselbaum RR, Lippman SM, et al: Head and neck cancer. N Engl J Med 328:184-194, 1993
49. Fazekas JT, Sommer C, Kramer S, et al: Adjuvant intravenous methotrexate or definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic larynx or hypo-pharynx. Concluding report of an RTOG randomzed trial on 638 patients. Int J Radiat Oncol Biol Phys 6:533-541, 1980
50. Arcangeli G, Nervi C, Righini R, et al: Combined radiation and drugs: The effect of intra-arterial chemotherapy followed by radiotherapy in head and neck cnacer. Radiother Oncol 1:101-107, 1983
51. Head and Neck Contracts Program: Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Final report of the Head and Neck Contracts Program. Cancer 60:301-311, 1987
52. Jacobs C, Makuch R: Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer; A subset analysis of the Head and Neck Contracts Program. J Clin Oncol 8:838-847, 1990
53. Schuller DE, Metch B, Mattox D, et al: Preoperative chemotherapy in advanced resectable head and neck cancer. Final report of the Southwest Oncology Group. Laryngoscope 98:1205-1211, 1988
54. Jortay A, Damard F, Dalesio O, et al: A randomized EORTC study on the effect of preoperative polychemotherapy in pyriform sinus carcinoma treated by pharyngolaryngectomy and irradiation: results from 5 to 10 years. Acta Chir Belg 90:115-122, 1990
55. Richard JM, Kramar A, Molinari RR, et al: Randomised EORTC head and neck cooperative group trial of preoperative intra-arterial chemotherapy in oral cavity and oropharynx carcinoma. Eur J Cancer 27:821-827, 1991
56. Jaulerry C, Rodriguez J, Brunin F, et al: Induction chemotherapy in advanced head and neck tumors: Results of two randomized trials. Int J Radiat Oncol Biol Phys 23:483-489, 1992
57. Mazeron JJ, Martin M, Brun B, et al: Induction chemotherapy in head and neck cancer: Results of a phase III trial. Head Neck 14:85-91, 1992
58. Gehanno P, Depondt J, Peynegre R, et al: Neoadjuvant combination of carboplatin and 5-FU in head and neck cancer; A randomized study. Ann Oncol 3:43-46, 1992 (suppl 3)
59. Paccagnella A, Orlando A, Marchiori C, et al: Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: A study by the Gruppo di Studio sui Tumori della Testa a del Collo. J Natl Cancer Inst 86:265-272, 1994
60. o) undifferentiated nasopharyngeal carcinoma: A positive effect on progression-free survival. Int J Radiat Oncol Biol Phys 35:463-469, 1996
61. Stell PM, Dalby JE, Strickland P, et al: Sequential chemotherapy and radiotherapy in advanced head and neck cancer. Clin Radiol 34:463-467, 1983
62. Kun LE, Toohill RJ, Holoye PY, et al: A randomzed study of adjuvant chemotherapy for cancer of the upper aerodigestive tract. Int J Radiat Oncol Biol Phys 12:173-178, 1986
63. Toohill RJ, Anderson T, Byhardt RW, et al: Cisplatin and fluorouracil as neoadjuvant therapy in head and neck cancer. A preliminary report. Arch Otolaryngol Head Neck Surg 113:758-761, 1987
64. Laramore GE, Scott CB, Al-Sarraf M, et al: Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: Report on Intergroup Study 0034. Int J Radiat Oncol Biol Phys 23:705-713, 1992
65. Stell PM, Rawson NSB: Adjuvant chemotherapy in head and neck cancer. Br J Cancer 61:779-87, 1990
66. Browman GP: Evidence-based recommendations against neoadjuvant chemotherapy for routine management of patients with squamous cell head and neck cancer. Cancer Invest 12:662-671, 1994
67. Munro AJ: An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer. Br J Cancer 71:83-91, 1995
68. El-Sayed S, Nelson N: Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinonma of the head and neck region: A meta-analysis of prospective and randomized trials. J Clin Oncol 14:838-847, 1996
69. The Department of Veterans Affairs Laryngeal Cancer Study Group: Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 324:1685-1690, 1991
70. Harwood AR, Hawkins NV, Beale FA, et al: Management of advanced glottic ancer. A 10-year review of the Toronto experience. Int J Radiat Oncol Biol Phys 5:899-904, 1979
71. Lo TCM, Wiley AL Jr, Ansfield FJ, et al: Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx; A randomized study. Am J Roentgenol 126:229-235, 1976
72. Stefani S, Chung TS: Hydroxyurea and radiotherapy in head and neck cancer - Long term results of a double-blind prospective study. Int J Radiat Oncol Biol Phys 6:1398, 1980
73. Shanta V, Krishnamurthi S: Combined bleomycin and radiotherapy in oral cancer. Clin Radiol 31:617-620, 1980
74. Vermund H, Kaalhus O, Winther F, et al: Bleomycin and radiation therapy in squamous cell carcinoma of the upper aerodigestive tract: A phase III clinical trial. Int J Radiat Oncol Biol Phys 11:1877-1886, 1985
75. Fu KK, Phillips TL, Silverberg IJ, et al: Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: Update of a Northern California Oncology Group randomized trial. J Clin Oncol 5:1410-1418, 1987
76. Eschwege F, Sancho-Garnier H, Gerard JP, et al: Ten-year results of randomized trial comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx: Experience of the European Organization for research and treatment of cancer. Natl Cancer Inst Monogr 6:275-278, 1988
77. Gupta NK, Pointon RCS, Wilkinson PM: A randomized clinical trial to contrast radiotherapy with radiotherapy and methotrexate given synchronously in head and neck cancer. Clin Radiol 38:575-581, 1987
78. Weissberg JB, Son YH, Papac RJ, et al: Randomized clinical trial of mitomycin-C as an adjunct to radiotherapy in head and neck cancer. Int J Radiat Oncol Biol Phys 17:3-9, 1989
79. Haffty BG, Son YH, Papac R, et al: Chemotherapy as an adjunct to radiation therapy in the treatment of squamous cell carcinoma of the head and neck: Results of the Yale mitomycin-C randomized trials. Proc Am Soc Clin Oncol 15:316, 1996 (abstr)
80. Sanchiz F, Milla A, Tomer J, et al: Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer. Int J Radiat Oncol Biol Phys 19:1347-1350, 1990
81. Keane TJ, Cummings BJ, O'Sullivan B, et al: A randomized trial of radiation therapy compared to split course radiation therapy combined with mitomycin-C and 5-fluorouracil as initial treatment for advanced laryngeal and hypopharyngeal squamous carcinoma. Int J Radiat Oncol Biol Phys 25:613-618, 1993
82. Wendt TG, Grabenbauer G, Thiel H-T, et al: Simultaneous radio-chemotherapy vs radiotherapy alone in stage III and IV carcinoma of the head and neck: Early results of a randomized study. Radiother Oncol 32: S154, 1994 (suppl, abstr)
83. Browman GP, Cripps C, Hodson DI, et al: Placebo-controlled randomized trial of infusional fluorouracil during standard radiotherapy in locally advanced head and neck cancer. J Clin Oncol 12:2648-2653, 1994
84. Al-Sarraf M, LeBlanc M, Giri PGS, et al: Superiority of chemo-radiotherapy in patients with locally advanced nasopharyngeal cancer. Preliminary results of Intergroup randomized study. Proc Am Soc Clin Oncol 15:313, 1996 (abstr)
85. Bachaud JM, David JM, Boussin G, et al: Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced squamous cell carcinoma of the head and neck: Preliminary report of a randomized trial. Int J Radiat Oncol Biol 20:243-246, 1991
86. Merlano M, Vitale V, Rosso R, et al: Treatment of advanced squamous cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. N Engl J Med 327:1115-1121, 1995
87. Rossi A, Molinari R, Boracchi P, et al: Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer: Results of a 4-year multicenter randomized study. J Clin Oncol 6:1401-1410, 1988
88. Domenge C, Marandas P, Vignoud J, et al: Post-surgical adjuvant chemotherapy in extracapsular spread invaded lymph node (N+ R+) of epidermoid carcinoma of the head and neck. A randomized multicentre trial. Boston, MA, Proceedings of the Second International Conference on Head and Neck Cancer, August, 1988, p 74 (abstr)
89. Dillman RO, Seagren SL, Propert KJ, et al: A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small cell lung cancer. N Engl J Med 323:940-945, 1990
90. Mattson K, Holsti LR, Holsti P, et al: Inoperable non-small cell lung cancer: Radiation with or without chemotherapy. Eur J Cancer Clin Oncol 24:477-482, 1988
91. Le Chevalier T, Arriagada R, Tarayre M, et al: Significant effect of adjuvant chemotherapy on survival in locally-advanced non-small cell lung carcinoma. J Natl Cancer Inst 84:58, 1992
92. Sause WT, Scott C, Taylor S, et al: Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588. Preliminary results of a phase III trial in regionally advanced unresectable non-small cell lung cancer. J Natl Cancer Inst 87:198-205, 1995
93. Schaake-Koning C, Van Den Bogaert W, Dalesio O, et al: Effects of concomitant cisplatin and radiotherapy on inoperable non-small cell lung cancer. N Engl J Med 326:524-530, 1992
94. Trovo MG, Minatel E, Franchin G, et al: Radiotherapy versus radiotherapy enhanced by cisplatin in stage II non-small cell lung cancer. Int J Radiat Oncol Biol Phys 24:11-15, 1992
95. Jeremic B, Shibamoto Y, Acimovic L, et al: Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small cell lung cancer. J Clin Oncol 13:452-448, 1995
96. Jeremic B, Shibamoto Y, Acimovic L, et al: Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small cell lung cancer: A randomized study. J Clin Oncol 14:1065-1070, 1996
97. Blanke C, Ansari R, Mantrayadi R, et al: Phase III trial of thoracic irradiation with or without cisplatin for locally advanced unresectable non-small cell lung cancer: A Hoosier Oncology Group protocol. J Clin Oncol 13:1425-1429, 1995
98. Non-small Cell Lung Cancer Collaborative Group: Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized trials. Br Med J 311:899-909, 1995
99. The Lung Cancer Study Group: Effects of postoperative mediastinal radiation on completely resected stage II and stage III epidermoid cancer of the lung. N Engl J Med 315:1377-1381, 1986
100. The Lung Cancer Study Group: The benefit of adjuvant treatment for resected locally advanced non-small cell lung cnacer. J Clin Oncol 6:9-17, 1988
101. Dautzenberg B, Chastang C, Arriagada R, et al: Adjuvant radiotherapy versus combined sequential chemotherapy followed by radiotherapy in the treatment of resected non-small cell lung carcinoma. Cancer 76:779-786, 1995
102. Bleehen NM, Cleland WP, Deeley TJ, et al: Radiotherapy alone or with chemotherapy in the treatment of small cell carcinoma of the lung: The results at 36 months. Br J Cancer 44:611-617, 1981
103. Souhami RL, Geddes DM, Spiro SG, et al: Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: A controlled trial. Br Med J 288:1643-1646, 1984
104. Perez CA, Einhorn L, Oldham RK, et al: Randomized trial of radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation: A preliminary report. J Clin Oncol 2:1200-1208, 1984
105. Kies MS, Mira JG, Crowley JJ, et al: Multinodal therapy for limited small cell lung cancer: A randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide field versus reduced field radiation in partial responders: A Southwest Oncology Group study. J Clin Oncol 5:592-600, 1987
106. Perry MC, Eaton WL, Propert KJ, et al: Chemotherapy with or without radiaton therapy in limited small-cell carcinoma of the lung. N Engl J Med 316:912-918, 1987
107. Johnson DH, Bass D, Einhorn LH, et al: Combination chemotherapy with or without thoracic radiotherapy in limited-stage small cell lung cancer: A randomized trial of the Southeastern Cancer Study Group. J Clin Oncol 11:1223-1229, 1993
108. Pignon J-P, Arriagada R, Ihde DC, et al: A meta-analysis of thoracic radiotherapy for small-cell lung cancer. N Engl J Med 327:1618-1624, 1992
109. Murray N, Coy P, Pater JL, et al: Importance of timing for thoracic irradiaton in the combined modality treatment of limited-stage small-cell lung cancer. J Clin Oncol 11:336-344, 1993
110. Herskovic A, Martz K, Al-Sarraf M, et al: Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 326:1593-1598, 1992
111. Al-Sarraf M, Martz K, Herskovic A, et al: Superiority of chemo-radiotherapy vs radiotherapy in patients with esophageal cancer. Final report of an Intergroup randomized and confirmed study. Proc Am Soc Clin Oncol 15:206, 1996 (abstr)
112. Gill PG, Denham JW, Jamieson GG, et al: Patterns of treatment failure and prognostic factors associated with the treatment of esophageal carcinoma with chemotherapy and radiotherapy either as sole treatment or followed by surgery. J Clin Oncol 10:1037-1043, 1992
113. Roussel A, Haegele P, Paillot B, et al: Results of the EORTC-GTCCG phase III trial of irradiation vs irradiation and CDDP in inoperable esophageal cancer. Proc Am Soc Clin Oncol 13:199, 1994 (abstr)
114. Bosset JF, Gignoux M, Triboulet JP, et al: Randomized phase III clinical trial comparing surgery alone versus pre-operative combined radio-chemotherapy in stage I-II epidermoid cancer of the thoracic esophagus. Preliminary analysis. Proc Am Soc Clin Oncol 13:197, 1994 (abstr)
115. Bleiberg H, Gerard B, Deguiral P: Adjuvant therapy in resectable gastric cancer. Br J Cancer 66:987-991, 1992
116. Hermans J, Bonenkamp JJ, Boom MC, et al: Adjuvant therapy after curative resection for gastric cancer: Meta-analysis of randomzed trials. J Clin Oncol 11:1441-1447, 1993
117. Hallissey MT, Dunn JA, Ward LC, et al: The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: Five-year follow-up. Lancet 343:1309-1312, 1994
118. Moertel CG, Childs DS Jr, Reitemeier RJ, et al: Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet 2:865-867, 1969
119. Moertel G, Frytak S, Hahn RG, et al: Therapy of locally unresectable pancreatic carcinoma: Randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil. Cancer 48:1705-1710, 1981
120. Gastrointestinal Tumor Study Group: Treatment of locally unresectable carcinoma of the pancreas: Comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 80:751-755, 1988
121. Klaassen DJ, MacIntyre JM, Catton GE, et al: Treatment of locally unresectable cancer of the stomach and pancreas: A randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil - An Eastern Cooperative Oncology Group study. J Clin Oncol 3:373-378, 1985
122. Gastrointestinal Tumor Study Group: Radiation therapy combined with Adriamycin or 5-fluorouracil for the treatment of locally unresectable pancreatic carcinoma. Cancer 56:2563-2568, 1985
123. Gastrointestinal Tumor Study Group: Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59:2006-2010, 1987
124. Laurie JA, Moertel CG, Fleming TR, et al: Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil. J Clin Oncol 7:1447-1456, 1989
125. Moertel CG, Fleming TR, MacDonald JS, et al: Fluorouracil plus Levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: A final report. Ann Intern Med 122:321-326, 1995
126. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT): Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 345:939-944, 1995
127. Buyse M, Zeleniuch-Jacquotte A, Chalmers TC: Adjuvant therapy of colorectal carncer. Why we still don't know. JAMA 259:3571-3578, 1988
128. Gray R, James R, Mossman J, et al: AXIS - A suitable case for treatment. Br J Cancer 63:841-845, 1991
129. Boulis-Wassif S, Gerard A, Loygue J, et al: Final results of a randomized trial on the treatment of rectal cancer with preoperative radiotherapy alone or in combination with 5-fluorouracil, followed by radical surgery. Trial of the European Organization on Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group. Cancer 53:1811-1818, 1984
130. Gastrointestinal Tumor Study Group: Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med 312:1465-1472, 1985
131. Krook JE, Moertel CG, Gunderson LL, et al: Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 324:709-715, 1991
132. Rockette H, Deutsch M, Petrelli N, et al: Effect of postoperative radiation therapy when used with adjuvant chemotherapy in Dukes' B and C rectal cancer: Results from NSABP-R02. Proc Am Soc Clin Oncol 13:193, 1994 (abstr)
133. NIH Consensus Conference: Adjuvant therapy for patients with colon and rectal cancer. JAMA 264:1444-1450, 1990
134. Bosset JF, Horiot JC: Adjuvant treatment in the curative management of rectal cancer: A critical review of the results of clinical randomized trials. Eur J Cancer 29A:770-774, 1993
135. Cummings BJ, Keane TJ, O'Sullivan B, et al: Epidermoid anal cancer: Treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin-C. Int J Radiat Oncol Biol Phys 21:1115-1125, 1991
136. Flam M, Madhu J, Pajak TF, et al: Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermal carcinoma of the anal canal: Results of a phase III randomized intergroup study. J Clin Oncol 14:2527-2539, 1996
137. Roelofsen F, Bosset JF, Eschwege F, et al: Concomitant radiotherapy and chemotherapy superior to radiotherapy alone in the treatment of locally advanced anal cancer. Results of a phase III randomized trial of the EORTC Radiotherapy and Gastrointestinal Cooperative Groups. Proc Am Soc Clin Oncol 14:194, 1995 (abstr)
138. Piver MS, Barlow JJ, Vongtama V, et al: Hydroxyurea as a radiation sensitizer in women with carcinoma of the uterine cervix. Am J Obstet Gynecol 129:379-383, 1977
139. Hreshchyshyn MM, Aaron BS, Boronow RC, et al: Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. Int J Radiat Oncol Biol Phys 5:317-322, 1979
140. Stehman FB, Bundy BN, Thomas G, et al: Hydroxyurea versus misonidazole with radiation in cervical carcinoma: Long-term follow-up of a Gynecologic Oncology Group trial. J Clin Oncol 11:1523-1528, 1993
141. Chauvergne J, Rohart J, Héron JF, et al: Essai randomisé de chimiothérapie initiale dans 151 carcinomas du col utérin localement étendus (T2bN1,T3b,M0). Bull Cancer 77:1007-1024, 1990
142. Souhami L, Gil RA, Allan SE, et al: A randomized trial of chemotherapy followed by pelvic radiation therapy in stage IIIB carcinoma of the cervix. J Clin Oncol 9:970-977, 1991
143. Tattersall MHN, Lorvidhaya V, Vootiprux V, et al: Randomized trial of epirubicin and cisplatin chemotherapy followed by pelvic radiation in locally advanced cervical cancer. J Clin Oncol 13:444-451, 1995
144. o bladder cancer treated with radiotherapy. Br J Urol 55:386-391, 1983
145. 3 carcinoma of the bladder; A prospective trial. A preliminary report. Br J Urol 62:558-564, 1988
146. Wallace DMA, Raghavan D, Kelly KA, et al: Neo-adjuvant (pre-emptive) cisplatin therapy in invasive transitional cell carcinoma of the bladder. Br J Ural 67:608-615, 1991
147. Malmström P-U, Rintala E, Wahlqvist R, et al: Five-year followup of a prospective trial of radical cystectomy and neoadjuvant chemotherapy: Nordic Cystectomy Trial I. J Urol 155:1903-1906, 1996
148. Coppin CML, Gospodarowicz MK, James K, et al: Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. J Clin Oncol (in press)
149. Hall RR: Neoadjuvant CMV chemotherapy and cystectomy or radiotherapy in muscle invasive bladder cancer. First analysis of MRC/EORTC intercontinental trial. Proc Am Soc Clin Oncol 15:244, 1996 (abstr)
150. Pilepich MV, Caplan R, Byhardt RW, et al: Phase III trial of adjuvant androgen suppression using goserelin in patients with carcinoma of the prostate treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys 32:188, 1995 (suppl, abstr)
151. Pilepich MV, Krall JM, Al-Sarraf M, et al: Androgen deprivation with radiation therapy compared with radiation therapy alone for locally advanced prostatic carcinoma - A randomized comparative trial of the Radiation Therapy Oncology Group. Urology 45:616-623, 1995
152. Bolla M, Gonzalez D, Warde P, et al: Immediate hormonal therapy improves locoregional control and survival in patients with locally advanced prostate cancer. Results of randomized phase III clinical trial of the EORTC Radiotherapy and Genitourinary Tract Cancer Cooperative Groups. Proc Am Soc Clin Oncol 15:238, 1996 (abstr)
153. Recht A, Come SE, Henderson IC, et al: The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. N Engl J Med 334:1356-1361, 1996
154. Doyle C, Tannock IF: Adjuvant radiation or systemic therapy for renal cell carcinoma: A brief review. Urol Oncol 1:161-165, 1995
155. Eilber FR, Morton DL, Eckardt J, et al: Limb salvage for skeletal and soft tissue sarcomas. Multidisciplinary preoperative treatment. Cancer 53: 2579-2584, 1984
156. Tierney JF: A meta-analysis using individual patient data from randomized clinical trials of adjuvant chemotherapy for soft tissue sarcomas. J Clin Oncol 14:1751, 1996 (abstr)