Reactions of artemisinin and arteether with acid: Implications for stability and mode of antimalarial action

Journal of Medicinal Chemistry

Volumn 49, Issue 20, 2006, Pages 6065-6073

  Drew, Michael G B ^a   Metcalfe, John ^a   Dascombe, Michael J ^b   Ismail, Fyaz M D ^c  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ARTEETHER; ARTEMISININ; FREE RADICAL; LEWIS ACID; PEROXIDE;

ANTIMALARIAL ACTIVITY; ARTICLE; DECOMPOSITION; DENSITY FUNCTIONAL THEORY; DRUG BINDING; DRUG MECHANISM; DRUG STABILITY; HYDROLYSIS; PROTON TRANSPORT; REACTION ANALYSIS;

ANIONS; ANTIMALARIALS; ARTEMISININS; ELECTRON TRANSPORT; FREE RADICALS; HYDROLYSIS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PROTONS; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 33749239620     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060673d     Document Type: Article

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