Artemisinin antimalarials do not inhibit hemozoin formation [3]

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 3, 2003, Pages 1175-

  Haynes, Richard K ^a   Monti, Diego ^b   Taramelli, Donatella ^b   Basilico, Nicoletta ^b   Parapini, Silvia ^b   Olliaro, Piero ^c  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b UNIVERSITY OF MILAN   (Italy)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

10 DEOXODIHYDROARTEMISININ; ANTIMALARIAL AGENT; ARTEMISININ; DIHYDROARTEMISININ; HEMATIN; HEME; HEMOZOIN; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; CONCENTRATION RESPONSE; DRUG MECHANISM; IN VITRO STUDY; LETTER; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RING OPENING;

ANTIMALARIALS; ARTEMISININS; HEME; HEMEPROTEINS; HEMIN; SESQUITERPENES;

EID: 0037416976     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.3.1175.2003     Document Type: Letter

References (6)

1. Asawamahasakda, W., I. Ittarat, C. C. Chang, P. McElroy, and S. R. Meshnick. 1994. Effects of antimalarials and protease inhibitors on plasmodial hemozoin production. Mol. Biochem. Parasitol. 67:183-191.
2. Basilico, N., E. Pagani, D. Monti, P. Olliaro, and D. Taramelli. 1998. A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs. Antimicrob. Chemother. 42:55-60.
3. Haynes, R. K., H.-O. Pai, and A. Voerste. 1999. Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with formation of N-oxides - a chemical model for antimalarial mode of action. Tetrahedron Lett. 40:4715-4718.
4. Olliaro, P. L., R. K. Haynes, B. Meunier, and Y. Yuthavong. 2001. Possible modes of action of the artemisinin-type compounds. Trends Parasitol. 17:122-126.
5. Pandey, A. V., B. L. Tekwani, R. L. Singh, and V. S. Chauhan. 1999. Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasites. J. Biol. Chem. 274:19383-19388.
6. Parapini, S., N. Basilico, E. Pasini, T. J. Egan, P. Olliaro, D. Taramelli, and D. Monti. 2000. Standardization of the physicochemical parameters to assess in vitro the beta-hematin inhibitory activity of antimalarial drugs. Exp. Parasitol. 96:249-256.