The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria

British Journal of Clinical Pharmacology

Volumn 53, Issue 1, 2002, Pages 23-30

  Davis, Timothy M E ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Artesunate; Dihydroartemisinin; Falciparurn malaria; Intramuscular injection; Pharmacokinetics; Rectal administration

Indexed keywords

ARTESUNATE; DIHYDROARTEMISININ; MEFLOQUINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HUMAN; MALARIA FALCIPARUM; MALE; MEAN RESIDENCE TIME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VIET NAM;

ADMINISTRATION, RECTAL; ADULT; ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; CONFIDENCE INTERVALS; CROSS-OVER STUDIES; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; MALARIA, FALCIPARUM; MALE; SESQUITERPENES; STATISTICS, NONPARAMETRIC;

EID: 0036159775     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2001.01519.x     Document Type: Article

References (29)

1. Artemisinin drugs in the treatment of malaria: From medicinal herb to registered medication
2. Pharmacokinetics of artemisinin-type compounds
3. Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria
4. Artesunate. A review of its pharmacology and therapeutic efficacy in the treatment of malaria
5. Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanian children with moderate malaria
6. Plasma levels of artesunate and dihydroartemisinin in children with Plasmodium falciparum malaria in Gabon after administration of 50 milligram artesunate suppositories
7. Comparison of artemlsinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria
8. An open randomized comparison of intravenous and intramuscular artesunate in severe falciparum malaria
9. Comparative clinical trial of artesunate suppositories and oral artesunate in combination with mefloquine in the treatment of children with acute falciparum malaria
10. A pharmacokinetic and pharmacodynamic study of artesunate for vivax malaria
11. Comparative pharmacokinetic study of oral and rectal formulations of artesunic acid in healthy volunteers
12. Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers
13. Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria
14. A pharmacokinetic and pharmacodynamic study of intravenous us oral artesunate in uncomplicated falciparum malaria
15. Antimalarial activity of new water-soluble dihydroartemisinin derivatives
16. Metabolism of antimalarial sesquiterpene lactones
17. Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria
18. Selective high-performance liquid chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria
19. Severe and complicated malaria treated with artemisinin, atresunate or artemether in Viet Nam
20. Pharmacokinetics of sodium artesunate after im and iv administration
21. Antimalarial bioavailability and disposition of atresunate in acute falciparum malaria
22. Pharmacokinetics of dihydroqinghaosu in human volunteers and comparison with quinghaosu
23. Pharmacokinctic study of a new pharmaceutical form of artesunate (Plasmotrim-200 Rectocaps) administered in healthy volunteers by rectal route
24. A comparative clinical trial of sequential treatments of severe malaria with artesunate suppository followed by mefloquine in Thailand
25. Artemisinin kinetics and dynamacs during oral and rectal treatment of uncomplicated malaria
26. In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs
27. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the westem border of Thailand