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Volumn 54, Issue 3-4, 1998, Pages 319-336

Synthesis of (+)-Artemisinin and (+)-Deoxoartemisinin from arteannuin B and arteannuic acid

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISINIC ACID; ARTEMISININ; DEOXOARTEMISININ;

EID: 0032518687     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)10286-1     Document Type: Article
Times cited : (57)

References (76)
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    • 1. (a) Klayman, D. L. Science, 1985, 228, 1049.
    • (1985) Science , vol.228 , pp. 1049
    • Klayman, D.L.1
  • 5
    • 0001856731 scopus 로고
    • Kinghorn, A. D. ed., American Chemical Society, Washingon DC
    • (b) Klayman, D. L. in Human Medicinal Agents from Plants , Kinghorn, A. D. ed., American Chemical Society, Washingon DC, 1993, 242.
    • (1993) Human Medicinal Agents from Plants , pp. 242
    • Klayman, D.L.1
  • 43
    • 0010749826 scopus 로고    scopus 로고
    • note
    • 12. (a) Modeling studies were conducted on an Evans and Sutherland terminal using Macromodel® v. 3.0 with MMII parameters. Upon initial minimization, several iterations of random manual structural perturbation and minimization were executed, a computerized conformational search was not executed.
  • 45
    • 0010750019 scopus 로고    scopus 로고
    • note
    • 3
  • 51
    • 0010712807 scopus 로고    scopus 로고
    • note
    • 3), both in the presence of CSA and with acid addition delayed until completion of the ozonolysis reaction. No artemisinin was detected by chromatographic or spectral analysis of the crude product.
  • 58
    • 0010660808 scopus 로고
    • John Wiley & sons: New York
    • (d) Caine, D. in: Organic Reactions, John Wiley & sons: New York 1976, vol 23, p. 73.
    • (1976) Organic Reactions , vol.23 , pp. 73
    • Caine, D.1
  • 61
  • 69
    • 0010665262 scopus 로고    scopus 로고
    • note
    • 25. Natural artemisinin was no longer detectable after stirring for several days at room temperature in aqueous perchloric acid.
  • 70
    • 0010749827 scopus 로고    scopus 로고
    • note
    • 26. In terms of reaction rate, trimethylsilyl triflate 〉 CSA 〉 Amberlyst® 15.
  • 71
    • 0010660809 scopus 로고    scopus 로고
    • note
    • 1H NMR using triphenylmethane as an internal standard. Quantitation was based on area comparison between the methine proton of triphenylmethane (δ 5.52 ppm) and the C-12 proton of artemisinin (δ 5.83 ppm). Spectra obtained for the purpose of yield determination were run with a delay time of 15 seconds to prevent errors associated with incomplete relaxation.
  • 74
    • 0010668242 scopus 로고    scopus 로고
    • note
    • 2O/Hex).
  • 75
    • 0010746950 scopus 로고    scopus 로고
    • note
    • 3). This spectrum was not as clean as the one in the previous note.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.