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note
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12. (a) Modeling studies were conducted on an Evans and Sutherland terminal using Macromodel® v. 3.0 with MMII parameters. Upon initial minimization, several iterations of random manual structural perturbation and minimization were executed, a computerized conformational search was not executed.
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note
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3), both in the presence of CSA and with acid addition delayed until completion of the ozonolysis reaction. No artemisinin was detected by chromatographic or spectral analysis of the crude product.
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0010665262
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note
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25. Natural artemisinin was no longer detectable after stirring for several days at room temperature in aqueous perchloric acid.
-
-
-
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70
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0010749827
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note
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26. In terms of reaction rate, trimethylsilyl triflate 〉 CSA 〉 Amberlyst® 15.
-
-
-
-
71
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0010660809
-
-
note
-
1H NMR using triphenylmethane as an internal standard. Quantitation was based on area comparison between the methine proton of triphenylmethane (δ 5.52 ppm) and the C-12 proton of artemisinin (δ 5.83 ppm). Spectra obtained for the purpose of yield determination were run with a delay time of 15 seconds to prevent errors associated with incomplete relaxation.
-
-
-
-
74
-
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0010668242
-
-
note
-
2O/Hex).
-
-
-
-
75
-
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0010746950
-
-
note
-
3). This spectrum was not as clean as the one in the previous note.
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-
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76
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0030003137
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32. Avery, M. A., Mebrotra, S., Bonk, J. D., Vroman, J. A., Goins, D. K. and Miller, R., J. Med. Chem., 1996, 39, 2900.
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Miller, R.6
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