메뉴 건너뛰기




Volumn 8, Issue 5, 2006, Pages 401-408

The impact of host pharmacogenetics on antiretroviral drug disposition

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER C2; ABC TRANSPORTER C4; AMPRENAVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; EFAVIRENZ; ENFUVIRTIDE; INDINAVIR; LAMIVUDINE; LOPINAVIR; MULTIDRUG RESISTANCE PROTEIN 1; NELFINAVIR; NEVIRAPINE; PREGNANE X RECEPTOR; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE; ZIDOVUDINE 5' TRIPHOSPHATE;

EID: 33749038880     PISSN: 15233847     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11908-006-0052-2     Document Type: Review
Times cited : (6)

References (64)
  • 1
    • 20144370827 scopus 로고    scopus 로고
    • Interruption of highly active antiretroviral therapy in HIV clinical practice: Results from the Italian Cohort of Antiretroviral-Naive Patients
    • d'arminio Monforte A, Cozzi-Lepri A, Phillips A, et al.: Interruption of highly active antiretroviral therapy in HIV clinical practice: results from the Italian Cohort of Antiretroviral-Naive Patients. J Acquir Immune Defic Syndr 2005, 38:407-416.
    • (2005) J Acquir Immune Defic Syndr , vol.38 , pp. 407-416
    • d'arminio Monforte, A.1    Cozzi-Lepri, A.2    Phillips, A.3
  • 2
    • 0038662719 scopus 로고    scopus 로고
    • Survival benefit of initiating antiretroviral therapy in HIV-infected persons in different CD4+ cell strata
    • Palella FJ Jr, Deloria-Knoll M, Chmiel JS, et al.: Survival benefit of initiating antiretroviral therapy in HIV-infected persons in different CD4+ cell strata. Ann Intern Med 2003, 138:620-626.
    • (2003) Ann Intern Med , vol.138 , pp. 620-626
    • Palella Jr., F.J.1    Deloria-Knoll, M.2    Chmiel, J.S.3
  • 3
    • 20444506418 scopus 로고    scopus 로고
    • Current status and future prospects of therapeutic drug monitoring and applied clinical pharmacology in antiretroviral therapy
    • Boffito M, Acosta E, Burger D, et al.: Current status and future prospects of therapeutic drug monitoring and applied clinical pharmacology in antiretroviral therapy. Antivir Ther 2005, 10:375-392.
    • (2005) Antivir Ther , vol.10 , pp. 375-392
    • Boffito, M.1    Acosta, E.2    Burger, D.3
  • 4
    • 9444267085 scopus 로고    scopus 로고
    • Functional interaction of intestinal CYP3A4 and P-glycoprotein
    • Kivisto KT, Niemi M, Fromm MF: Functional interaction of intestinal CYP3A4 and P-glycoprotein. Fundam Clin Pharmacol 2004, 18:621-626.
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 621-626
    • Kivisto, K.T.1    Niemi, M.2    Fromm, M.F.3
  • 5
    • 33645876468 scopus 로고    scopus 로고
    • MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype
    • Lamba J, Strom S, Venkataramanan R, et al.: MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. Clin Pharmacol Ther 2006, 79:325-338.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 325-338
    • Lamba, J.1    Strom, S.2    Venkataramanan, R.3
  • 6
    • 31144438802 scopus 로고    scopus 로고
    • Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: Application of in vitro and ex situ systems
    • Lau YY, Okochi H, Huang Y, Benet LZ: Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther 2006, 316:762-771.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 762-771
    • Lau, Y.Y.1    Okochi, H.2    Huang, Y.3    Benet, L.Z.4
  • 7
    • 1342302110 scopus 로고    scopus 로고
    • Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: Hepatic enzyme-transporter interplay
    • Lau YY, Wu CY, Okochi H, Benet LZ: Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther 2004, 308:1040-1045.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1040-1045
    • Lau, Y.Y.1    Wu, C.Y.2    Okochi, H.3    Benet, L.Z.4
  • 8
    • 0037216648 scopus 로고    scopus 로고
    • Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation
    • Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther 2003, 304:223-228.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 223-228
    • Tirona, R.G.1    Leake, B.F.2    Wolkoff, A.W.3    Kim, R.B.4
  • 9
    • 24344439264 scopus 로고    scopus 로고
    • Transporters and drug therapy: Implications for drug disposition and disease
    • Ho RH, Kim RB: Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther 2005, 78:260-277.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 260-277
    • Ho, R.H.1    Kim, R.B.2
  • 10
    • 84869984524 scopus 로고    scopus 로고
    • Pharmacogenetics of nevirapine and hepatotoxicity: NWCS220, an ACTG collaborative study
    • Accessed July 17
    • Haas DW, Bartlett J, Andersen J, et al.: Pharmacogenetics of nevirapine and hepatotoxicity: NWCS220, an ACTG collaborative study. http://www.retroconference.org/2005/cd/Abstracts/24568.htm. Accessed July 17, 2006.
    • (2006)
    • Haas, D.W.1    Bartlett, J.2    Andersen, J.3
  • 11
    • 84869981847 scopus 로고    scopus 로고
    • Relevance of drug transporttes and drug metabolism enzymes to nevirapine: Superimposition of host genotype
    • Accessed July 17
    • Owen A, Almond L, Hartkoorn R, et al.: Relevance of drug transporttes and drug metabolism enzymes to nevirapine: superimposition of host genotype. http://www.retroconference.org/2005/cd/Abstracts/24878.htm. Accessed July 17, 2006.
    • (2006)
    • Owen, A.1    Almond, L.2    Hartkoorn, R.3
  • 12
    • 84869984729 scopus 로고    scopus 로고
    • Evaluation of efavirenz transport by P-glycoprotein and uptake transporters
    • Accessed July 17
    • Marzolini C, Leake B, Schwarz U, et al.: Evaluation of efavirenz transport by P-glycoprotein and uptake transporters. http://www.retroconference.org/2006/Abstracts/26189.htm. Accessed July 17, 2006.
    • (2006)
    • Marzolini, C.1    Leake, B.2    Schwarz, U.3
  • 13
    • 0033790624 scopus 로고    scopus 로고
    • Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons
    • Fletcher CV, Kawle SP, Kakuda TN, et al.: Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons. AIDS 2000, 14:2137-2144.
    • (2000) AIDS , vol.14 , pp. 2137-2144
    • Fletcher, C.V.1    Kawle, S.P.2    Kakuda, T.N.3
  • 14
    • 0026489591 scopus 로고
    • Resistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein
    • Antonelli G, Turriziani O, Cianfriglia M, et al.: Resistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein. AIDS Res Hum Retroviruses 1992, 8:1839-1844.
    • (1992) AIDS Res Hum Retroviruses , vol.8 , pp. 1839-1844
    • Antonelli, G.1    Turriziani, O.2    Cianfriglia, M.3
  • 15
    • 0032879904 scopus 로고    scopus 로고
    • MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
    • Schuetz JD, Connelly MC, Sun D, et al.: MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 1999, 5:1048-1051.
    • (1999) Nat Med , vol.5 , pp. 1048-1051
    • Schuetz, J.D.1    Connelly, M.C.2    Sun, D.3
  • 16
    • 12944270590 scopus 로고    scopus 로고
    • Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
    • Wijnholds J, Mol CA, van Deemter L, et al.: Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 2000, 97:7476-7481.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7476-7481
    • Wijnholds, J.1    Mol, C.A.2    van Deemter, L.3
  • 17
    • 0032467105 scopus 로고    scopus 로고
    • Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine
    • Ritzel MW, Yao SY, Ng AM, et al.: Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/ nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol Membr Biol 1998, 15:203-211.
    • (1998) Mol Membr Biol , vol.15 , pp. 203-211
    • Ritzel, M.W.1    Yao, S.Y.2    Ng, A.M.3
  • 18
    • 0034918036 scopus 로고    scopus 로고
    • Transport of antiviral 3′-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes
    • Yao SY, Ng AM, Sundaram M, et al.: Transport of antiviral 3′-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol 2001, 18:161-167.
    • (2001) Mol Membr Biol , vol.18 , pp. 161-167
    • Yao, S.Y.1    Ng, A.M.2    Sundaram, M.3
  • 19
    • 4744351346 scopus 로고    scopus 로고
    • Association of the CYP3A5 A6986G (CYP3A5*3) polymorphism with saquinavir pharmacokinetics
    • Frohlich M, Hoffmann MM, Burhenne J, et al.: Association of the CYP3A5 A6986G (CYP3A5*3) polymorphism with saquinavir pharmacokinetics. Br J Clin Pharmacol 2004, 58:443-444.
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 443-444
    • Frohlich, M.1    Hoffmann, M.M.2    Burhenne, J.3
  • 20
    • 28844459455 scopus 로고    scopus 로고
    • Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5
    • Mouly SJ, Matheny C, Paine MF, et al.: Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5. Clin Pharmacol Ther 2005, 78:605-618.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 605-618
    • Mouly, S.J.1    Matheny, C.2    Paine, M.F.3
  • 21
    • 0037123351 scopus 로고    scopus 로고
    • Re: Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    • [letter] author reply 631-632
    • Wojnowski L, Hustert E, Klein K, et al.: Re: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4 [letter]. J Natl Cancer Inst 2002, 94:630-631; author reply 631-632.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 630-631
    • Wojnowski, L.1    Hustert, E.2    Klein, K.3
  • 22
    • 15744390776 scopus 로고    scopus 로고
    • Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype
    • Lee SJ, Bell DA, Coulter SJ, et al.: Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype. J Pharmacol Exp Ther 2005, 313:302-309.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 302-309
    • Lee, S.J.1    Bell, D.A.2    Coulter, S.J.3
  • 23
    • 27944460707 scopus 로고    scopus 로고
    • Pharmacogenetics of long-term responses to antiretroviral regimens containing efavirenz and/or nelfinavir: An Adult AIDS Clinical Trials Group study
    • Haas DW, Smeaton LM, Shafer RW, et al.: Pharmacogenetics of long-term responses to antiretroviral regimens containing efavirenz and/or nelfinavir: an Adult AIDS Clinical Trials Group study. J Infect Dis 2005, 192:1931-1942.
    • (2005) J Infect Dis , vol.192 , pp. 1931-1942
    • Haas, D.W.1    Smeaton, L.M.2    Shafer, R.W.3
  • 24
    • 27944492382 scopus 로고    scopus 로고
    • Genetic variability of CYP2B6 in populations of African and Asian origin: Allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz
    • Klein K, Lang T, Saussele T, et al.: Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz. Pharmacogenet Genomics 2005, 15:861-873.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 861-873
    • Klein, K.1    Lang, T.2    Saussele, T.3
  • 25
    • 0034948077 scopus 로고    scopus 로고
    • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver
    • Lang T, Klein K, Fischer J, et al.: Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 2001, 11:399-415.
    • (2001) Pharmacogenetics , vol.11 , pp. 399-415
    • Lang, T.1    Klein, K.2    Fischer, J.3
  • 26
    • 33749008912 scopus 로고    scopus 로고
    • The impact of Cytochrome P450 polymorphisms on expression of drug-metabolising enzymes in lymphocytes
    • Owen A, Cook C, Liptrott N, et al.: The impact of Cytochrome P450 polymorphisms on expression of drug-metabolising enzymes in lymphocytes. Drug Metabolism Reviews 2006, 38:5-5.
    • (2006) Drug Metabolism Reviews , vol.38 , pp. 5-5
    • Owen, A.1    Cook, C.2    Liptrott, N.3
  • 27
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous system side effects: An Adult AIDS Clinical Trials Group study
    • Haas DW, Ribaudo HJ, Kim RB, et al.: Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS 2004, 18:2391-2400.
    • (2004) AIDS , vol.18 , pp. 2391-2400
    • Haas, D.W.1    Ribaudo, H.J.2    Kim, R.B.3
  • 28
    • 17644414659 scopus 로고    scopus 로고
    • Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects
    • Rodriguez-Novoa S, Barreiro P, Rendon A, et al.: Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects. Clin Infect Dis 2005, 40:1358-1361.
    • (2005) Clin Infect Dis , vol.40 , pp. 1358-1361
    • Rodriguez-Novoa, S.1    Barreiro, P.2    Rendon, A.3
  • 29
    • 20244364148 scopus 로고    scopus 로고
    • Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
    • Rotger M, Colombo S, Furrer H, et al.: Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. Pharmacogenet Genomics 2005, 15:1-5.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 1-5
    • Rotger, M.1    Colombo, S.2    Furrer, H.3
  • 30
    • 84869981578 scopus 로고    scopus 로고
    • Multilocus gene-gene interactions may predict efavirenz pharmacokinetics and treatment response: Analysis NWCS 213 of ACTG study 384
    • Accessed July 17
    • Motsinger A, Ritchie M, Shafer R, et al.: Multilocus gene-gene interactions may predict efavirenz pharmacokinetics and treatment response: analysis NWCS 213 of ACTG study 384. http://www.retroconference.org/2006/Abstracts/27301.htm. Accessed July 17, 2006.
    • (2006)
    • Motsinger, A.1    Ritchie, M.2    Shafer, R.3
  • 31
    • 84869985042 scopus 로고    scopus 로고
    • CYP2B6-G516T polymorphisms influence plasma concentrations of efavirenz in HIV-1-infected children receiving HAART
    • Accessed July 17
    • Saitoh A, Fletcher C, Brundage R, et al.: CYP2B6-G516T polymorphisms influence plasma concentrations of efavirenz in HIV-1-infected children receiving HAART. http://www.retroconference.org/2006/Abstracts/ 27070.htm. Accessed July 17, 2006.
    • (2006)
    • Saitoh, A.1    Fletcher, C.2    Brundage, R.3
  • 32
    • 84869983287 scopus 로고    scopus 로고
    • Genetic variability of CYP2B6 in individuals with extremely high efavirenz plasma concentrations
    • Accessed July 17
    • Rotger M, Colombo S, Cavassini M, et al.: Genetic variability of CYP2B6 in individuals with extremely high efavirenz plasma concentrations. http://www.retroconference.org/2006/Abstracts/27331.htm. Accessed July 17, 2006.
    • (2006)
    • Rotger, M.1    Colombo, S.2    Cavassini, M.3
  • 33
    • 0037515661 scopus 로고    scopus 로고
    • A novel distal enhancer module regulated by pregnane X receptor/ constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression
    • Wang H, Faucette S, Sueyoshi T, et al.: A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J Biol Chem 2003, 278:14146-14152.
    • (2003) J Biol Chem , vol.278 , pp. 14146-14152
    • Wang, H.1    Faucette, S.2    Sueyoshi, T.3
  • 34
    • 0033525886 scopus 로고    scopus 로고
    • The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
    • Sueyoshi T, Kawamoto T, Zelko I, et al.: The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 1999, 274:6043-6046.
    • (1999) J Biol Chem , vol.274 , pp. 6043-6046
    • Sueyoshi, T.1    Kawamoto, T.2    Zelko, I.3
  • 35
    • 23644459261 scopus 로고    scopus 로고
    • Genetic factors influencing pyrimidine-antagonist chemotherapy
    • Maring JG, Groen HJ, Wachters FM, et al.: Genetic factors influencing pyrimidine-antagonist chemotherapy. Pharmacogenomics J 2005, 5:226-243.
    • (2005) Pharmacogenomics J , vol.5 , pp. 226-243
    • Maring, J.G.1    Groen, H.J.2    Wachters, F.M.3
  • 36
    • 25144433260 scopus 로고    scopus 로고
    • Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
    • Wang D, Johnson AD, Papp AC, et al.: Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics 2005, 15:693-704.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 693-704
    • Wang, D.1    Johnson, A.D.2    Papp, A.C.3
  • 37
    • 1642523162 scopus 로고    scopus 로고
    • Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance
    • Marzolini C, Paus E, Buclin T, Kim RB: Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther 2004, 75:13-33.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 13-33
    • Marzolini, C.1    Paus, E.2    Buclin, T.3    Kim, R.B.4
  • 38
    • 20044362282 scopus 로고    scopus 로고
    • The implications of P-glycoprotein in HIV: Friend or foe?
    • Owen A, Chandler B, Back DJ: The implications of P-glycoprotein in HIV: friend or foe? Fundam Clin Pharmacol 2005, 19:283-296.
    • (2005) Fundam Clin Pharmacol , vol.19 , pp. 283-296
    • Owen, A.1    Chandler, B.2    Back, D.J.3
  • 39
    • 15944414161 scopus 로고    scopus 로고
    • An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    • Saitoh A, Singh KK, Powell CA, et al.: An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children. AIDS 2005, 19:371-380.
    • (2005) AIDS , vol.19 , pp. 371-380
    • Saitoh, A.1    Singh, K.K.2    Powell, C.A.3
  • 40
    • 27944466136 scopus 로고    scopus 로고
    • Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy
    • Verstuyft C, Marcellin F, Morand-Joubert L, et al.: Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy. AIDS 2005, 19:2127-2131.
    • (2005) AIDS , vol.19 , pp. 2127-2131
    • Verstuyft, C.1    Marcellin, F.2    Morand-Joubert, L.3
  • 41
    • 84869980104 scopus 로고    scopus 로고
    • Multi-drug resistance-1 gene and indinavir concentration in cerebrospinal fluid and plasma from HIV-infected individuals
    • Accessed July 17
    • Marquie-Beck J, Ellis R, Buzzell M, et al.: Multi-drug resistance-1 gene and indinavir concentration in cerebrospinal fluid and plasma from HIV-infected individuals. http://www.retroconference.org/2006/Abstracts/ 27807.htm. Accessed July 17, 2006.
    • (2006)
    • Marquie-Beck, J.1    Ellis, R.2    Buzzell, M.3
  • 42
    • 33744501248 scopus 로고    scopus 로고
    • Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance
    • Leschziner G, Zabaneh D, Pirmohamed M, et al.: Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. Pharmacogenet Genomics 2006, 16:439-450.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 439-450
    • Leschziner, G.1    Zabaneh, D.2    Pirmohamed, M.3
  • 43
    • 11144329541 scopus 로고    scopus 로고
    • Linkage disequilibrium and haplotype architecture for two ABC transporter genes (ABCC1 and ABCG2) in Chinese population: Implications for pharmacogenomic association studies
    • Wang H, Hao B, Zhou K, et al.: Linkage disequilibrium and haplotype architecture for two ABC transporter genes (ABCC1 and ABCG2) in Chinese population: implications for pharmacogenomic association studies. Ann Hum Genet 2004, 68:563-573.
    • (2004) Ann Hum Genet , vol.68 , pp. 563-573
    • Wang, H.1    Hao, B.2    Zhou, K.3
  • 44
    • 23444439167 scopus 로고    scopus 로고
    • Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo
    • Colombo S, Soranzo N, Rotger M, et al.: Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. Pharmacogenet Genomics 2005, 15:599-608.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 599-608
    • Colombo, S.1    Soranzo, N.2    Rotger, M.3
  • 45
    • 6344294111 scopus 로고    scopus 로고
    • Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4
    • Owen A, Chandler B, Bray PG, et al.: Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4. J Virol 2004, 78:12022-12029.
    • (2004) J Virol , vol.78 , pp. 12022-12029
    • Owen, A.1    Chandler, B.2    Bray, P.G.3
  • 46
    • 0034971274 scopus 로고    scopus 로고
    • The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells
    • Hitzl M, Drescher S, van der Kuip H, et al.: The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells. Pharmacogenetics 2001, 11:293-298.
    • (2001) Pharmacogenetics , vol.11 , pp. 293-298
    • Hitzl, M.1    Drescher, S.2    van der Kuip, H.3
  • 47
    • 27144514512 scopus 로고    scopus 로고
    • MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells
    • Woodahl EL, Yang Z, Bui T, et al.: MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells. AIDS 2005, 19:1617-1625.
    • (2005) AIDS , vol.19 , pp. 1617-1625
    • Woodahl, E.L.1    Yang, Z.2    Bui, T.3
  • 48
    • 17644420379 scopus 로고    scopus 로고
    • Strong linkage disequilibrium at the nucleotide analogue transporter ABCC5 gene locus
    • Gwee PC, Tang K, Sew PH, et al.: Strong linkage disequilibrium at the nucleotide analogue transporter ABCC5 gene locus. Pharmacogenet Genomics 2005, 15:91-104.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 91-104
    • Gwee, P.C.1    Tang, K.2    Sew, P.H.3
  • 49
    • 20244367613 scopus 로고    scopus 로고
    • Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2
    • Owen RP, Gray JH, Taylor TR, et al.: Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenet Genomics 2005, 15:83-90.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 83-90
    • Owen, R.P.1    Gray, J.H.2    Taylor, T.R.3
  • 50
    • 29944433943 scopus 로고    scopus 로고
    • Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2
    • Owen RP, Lagpacan LL, Taylor TR, et al.: Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. Drug Metab Dispos 2006, 34:12-15.
    • (2006) Drug Metab Dispos , vol.34 , pp. 12-15
    • Owen, R.P.1    Lagpacan, L.L.2    Taylor, T.R.3
  • 51
    • 0036246271 scopus 로고    scopus 로고
    • Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR
    • Saito S, Iida A, Sekine A, et al.: Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR. J Hum Genet 2002, 47:147-171.
    • (2002) J Hum Genet , vol.47 , pp. 147-171
    • Saito, S.1    Iida, A.2    Sekine, A.3
  • 52
    • 33745929357 scopus 로고    scopus 로고
    • Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: A pilot study
    • Anderson PL, Lamba J, Aquilante CL, et al.: Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. J Acquir Immune Defic Syndr 2006, 42:441-449.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 441-449
    • Anderson, P.L.1    Lamba, J.2    Aquilante, C.L.3
  • 53
    • 0036155217 scopus 로고    scopus 로고
    • Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine
    • Li JH, Xu JQ, Cao XM, et al.: Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine. Clin Chim Acta 2002, 317:85-92.
    • (2002) Clin Chim Acta , vol.317 , pp. 85-92
    • Li, J.H.1    Xu, J.Q.2    Cao, X.M.3
  • 55
    • 0031979994 scopus 로고    scopus 로고
    • Caucasian versus African-American differences in orosomucoid: Potential implications for therapy
    • McCollam PL, Crouch MA, Arnaud P: Caucasian versus African-American differences in orosomucoid: potential implications for therapy. Pharmacotherapy 1998, 18:620-626.
    • (1998) Pharmacotherapy , vol.18 , pp. 620-626
    • McCollam, P.L.1    Crouch, M.A.2    Arnaud, P.3
  • 56
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001, 276:14581-14587.
    • (2001) J Biol Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 57
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, et al.: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 1998, 102:1016-1023.
    • (1998) J Clin Invest , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3
  • 58
    • 0035823528 scopus 로고    scopus 로고
    • Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR
    • Dussault I, Lin M, Hollister K, et al.: Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. J Biol Chem 2001, 276:33309-33312.
    • (2001) J Biol Chem , vol.276 , pp. 33309-33312
    • Dussault, I.1    Lin, M.2    Hollister, K.3
  • 59
    • 6344240478 scopus 로고    scopus 로고
    • Induction of CYP3A4 by efavirenz in primary human hepatocytes: Comparison with rifampin and phenobarbital
    • Hariparsad N, Nallani SC, Sane RS, et al.: Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. J Clin Pharmacol 2004, 44:1273-1281.
    • (2004) J Clin Pharmacol , vol.44 , pp. 1273-1281
    • Hariparsad, N.1    Nallani, S.C.2    Sane, R.S.3
  • 60
    • 7244225172 scopus 로고    scopus 로고
    • Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA
    • Owen A, Chandler B, Back DJ, Khoo SH: Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA. Antivir Ther 2004, 9:819-821.
    • (2004) Antivir Ther , vol.9 , pp. 819-821
    • Owen, A.1    Chandler, B.2    Back, D.J.3    Khoo, S.H.4
  • 61
    • 23144435169 scopus 로고    scopus 로고
    • Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics
    • Lamba J, Lamba V, Schuetz E: Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics. Curr Drug Metab 2005, 6:369-383.
    • (2005) Curr Drug Metab , vol.6 , pp. 369-383
    • Lamba, J.1    Lamba, V.2    Schuetz, E.3
  • 62
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
    • Dorr P, Westby M, Dobbs S, et al.: Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother 2005, 49:4721-4732.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3
  • 63
    • 20444470810 scopus 로고    scopus 로고
    • Population pharmacokinetics and exposure-response relationship of enfuvirtide in treatment-experienced human immunodeficiency virus type 1-infected patients
    • Mould DR, Zhang X, Nieforth K, et al.: Population pharmacokinetics and exposure-response relationship of enfuvirtide in treatment-experienced human immunodeficiency virus type 1-infected patients. Clin Pharmacol Ther 2005, 77:515-528.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 515-528
    • Mould, D.R.1    Zhang, X.2    Nieforth, K.3
  • 64
    • 15344350690 scopus 로고    scopus 로고
    • Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV
    • Walker DK, Abel S, Comby P, et al.: Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV. Drug Metab Dispos 2005, 33:587-595.
    • (2005) Drug Metab Dispos , vol.33 , pp. 587-595
    • Walker, D.K.1    Abel, S.2    Comby, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.