Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2

Pharmacogenetics and Genomics

Volumn 15, Issue 2, 2005, Pages 83-90

  Owen, Ryan P ^a   Gray, Jennifer H ^a   Taylor, Travis R ^a   Carlson, Elaine J ^a   Huang, Conrad C ^a   Kawamoto, Michiko ^a   Johns, Susan J ^a   Stryke, Doug ^a   Ferrin, Thomas E ^a   Giacomini, Kathleen M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE   (United States)

Author keywords

Genetic variation; Human polymorphisms; Nucleoside analogs; Nucleoside transporter; Pharmacogenetics; Ribavirin

Indexed keywords

COMPLEMENTARY RNA; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 2; INOSINE; NUCLEOSIDE; NUCLEOSIDE ANALOG; NUCLEOSIDE TRANSPORTER; RIBAVIRIN; TRITIUM; UNCLASSIFIED DRUG; URIDINE;

AFRICAN AMERICAN; ANIMAL CELL; ARTICLE; ASIAN; CAUCASIAN; DRUG ABSORPTION; DRUG DISPOSITION; ETHNIC GROUP; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; ISOTOPE LABELING; MAJOR CLINICAL STUDY; NONHUMAN; OOCYTE; PHARMACOGENETICS; PLASMID; PRIORITY JOURNAL; XENOPUS LAEVIS;

EID: 20244367613     PISSN: 17446872     EISSN: None     Source Type: Journal    
DOI: 10.1097/01213011-200502000-00004     Document Type: Article

References (20)

1. Gray JH, Owen RP, Giacomini KM. The concentrative nucleoside transporter family, SLC28. Pflugers Arch 2004; 447:728-734.
2. +-nucleoside cotransporter (hCNT1). Am J Physiol 1997; 272:C707-C714.
3. +-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem 2001; 276:2914-2927.
4. +-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am J Physiol 1997; 273:F1058-F1065.
5. Pearlman BL. Hepatitis C infection: a clinical review. South Med J 2004; 97:364-373.
6. Main J, McCarron B, Thomas HC. Treatment of chronic viral hepatitis. Antivir Chem Chemother 1998; 9:449-460.
7. Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, et al. Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. Mol Pharmacol 2004; 65:512-519.
8. Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, et al. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci USA 2003; 100:5896-5901.
9. Tajima F. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 1989; 123:585-595.
10. Hartl DL, Clark AG. Principles of Population Genetics, 3rd edn. Sunderland, Massachusetts: Sinauer Associates; 1997.
11. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68:978-989.
12. + channels radically alters activation and inactivation. J Neurosci 1997; 17:32-44.
13. +/nucleoside transporter in Xenopus laevis oocytes. Biochem J 1991; 278:605-607.
14. +-nucleoside purine (N1) transporter. Pharm Res 1998; 15:950-952.
15. Nebert DW. Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes. Hum Mutat 2002; 20:463-472.
16. + nucleoside cotransporters hCNT1 and hCNT2. J Biol Chem 1999; 274:24475-24484.
17. Stephens JC, Schneider JA, Tanguay DA, Choi J, Acharya T, Stanley SE, et al. Haplotype variation and linkage disequilibrium in 313 human genes. Science 2001; 293:489-493.
18. Grantham R. Amino acid difference formula to help explain protein evolution. Science 1974; 185:862-864.
19. +-nucleoside transporter. J Biol Chem 1999; 274:2298-2302.
20. +-dependent nucleoside transporters. Pharm Res 1997; 14:1524-1532.