Developmental imaging genetics: Challenges and promises for translational research

Development and Psychopathology

Volumn 18, Issue 3, 2006, Pages 877-892

  Viding, Essi ^a   Williamson, Douglas E ^b   Hariri, Ahmad R ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; SEROTONIN AGONIST;

ANTISOCIAL BEHAVIOR; ANXIETY DISORDER; ARTICLE; BEHAVIOR DISORDER; BRAIN FUNCTION; DEPRESSION; DEVELOPMENTAL DISORDER; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC EPIDEMIOLOGY; GENETIC RISK; HUMAN; MAGNETOENCEPHALOGRAPHY; MEDICAL RESEARCH; MENTAL DISEASE; MOLECULAR BIOLOGY; MOOD DISORDER; NEUROIMAGING; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PANIC; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROGNOSIS; PUBLIC HEALTH; RISK FACTOR;

ANTISOCIAL PERSONALITY DISORDER; BRAIN; ELECTROENCEPHALOGRAPHY; HUMANS; INTERDISCIPLINARY COMMUNICATION; MAGNETIC RESONANCE IMAGING; MENTAL DISORDERS; RESEARCH; SEROTONIN;

EID: 33749020312     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579406060433     Document Type: Article

References (102)

1. Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004). Early-life blockade of the 5HT transporter alters emotional behavior in adult mice. Science, 306, 879-881.
2. Azmitia, E. C., & Gannon, P. J. (1986). The primate serotonergic system: A review of human and animal studies and a report on macaca fascicularis. Advances in Neurology, 43, 407-468.
3. Bailey, S. (2002). Expert paper: Antisocial personality disorder: Children and adolescents. London: NHS National Programme on Forensic Mental Health Research and Development.
4. Beauregard, M., Levesque, J., & Bourgouin, P. (2001). Neural correlates of conscious self-regulation of emotion. Journal of Neuroscience, 21, RC165.
5. Bennett, A. J., Lesch, K. P., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., et al. (2002). Early experience and serotonin transporter gene variation interact to influence primate CNS function. Molecular Psychiatry, 7, 118-122.
6. Bertolino, A., Arciero, G., Rubino, V., Latorre, V., De Candia, M., Mazzola, V., et al. (2005). Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style. Biological Psychiatry, 57, 1517-1525.
7. Blier, P., & de Montigny, C. (1999). Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology, 21(Suppl), 91S-98S.
8. Brown, S. M., Peet, E., Manuck, S. B., Williamson, D. E., Dahl, R. E., Ferrell, R. E., et al. (2005). A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular Psychiatry, 10, 884-888.
9. Canli, T., Omura, K., Haas, B. W., Fallgatter, A., Constable, R. T., & Lesch, K. P. (2005). Beyond affect: A role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences of the United States of America, 102, 12224-12229.
10. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
11. Champoux, M., Bennett, A., Shannon, C., Higley, J. D., Lesch, K. P., & Suomi, S. J. (2002). Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Molecular Psychiatry, 7, 1058-1063.
12. Cicchetti, D., & Cannon, T. D. (1999). Neurodevelopmental processes in the ontogenesis and epigenesis of psychopathology. Developmental Psychopathology, 11, 375-393.
13. Cloninger, C. R. (1986). A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatric Developments, 4, 167-226.
14. Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives in General Psychiatry, 50, 975-990.
15. Curtis, W. J., & Cicchetti, D. (2003). Moving research on resilience into the 21st century: Theoretical and methodological considerations in examining the biological contributors to resilience. Developmental Psychopathology, 15, 773-810.
16. Domschke, K., Braun, M., Ohrmann, P., Suslow, T., Kugel, H., Bauer, J., et al. (2005). Association of the functional - 1019c/g 5-HT 1a polymorphism with prefrontal cortex and amygdala activation measured with 3 t fMRI in panic disorder. International Journal of Neuropsychopharmacology, 9, 349-355.
17. Du, L., Bakish, D., & Hrdina, P. D. (2000). Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatric Genetics, 10, 159-164.
18. Eggers, B., Hermann, W., Barthel, H., Sabri, O., Wagner, A., & Hesse, S. (2003). The degree of depression in hamilton rating scale is correlated with the density of presynaptic serotonin transporters in 23 patients with Wilson's disease. Journal of Neurology, 250, 576-580.
19. Eley, T. C., Lichtenstein, P., & Moffitt, T. E. (2003). A longitudinal behavioral genetic analysis of the etiology of aggressive and nonaggressive antisocial behavior. Developmental Psychopathology, 15, 383-402.
20. Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., et al. (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908-915.
21. Esaki, T., Cook, M., Shimoji, K., Murphy, D. L., Sokoloff, L., & Holmes, A. (2005). Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Proceedings of the National Academy of Sciences of the United States of America, 102, 5582-5587.
22. Frick, P. J., Cornell, A. H., Barry, C. T., Bodin, S. D., & Dane, H. E. (2003). Callous-unemotional traits and conduct problems in the prediction of conduct problem severity, aggression, and self-report of delinquency. Journal of Abnormal Child Psychology, 31, 457-470.
23. Furmark, T., Tillfors, M., Garpenstrand, H., Marteinsdottir, I., Langstrom, B., Oreland, L., et al. (2004). Serotonin transporter polymorphism linked to amygdala excitability and symptom severity in patients with social phobia. Neuroscience Letters, 362, 1-4.
24. Garpenstrand, H., Annas, P., Ekblom, J., Oreland, L., & Fredrikson, M. (2001). Human fear conditioning is related to dopaminergic and serotonergic biological markers. Behavioral Neuroscience, 115, 358-364.
25. Gaspar, P. (2004). Genetic models to understand how serotonin acts during development. Journal de la Société de Biologie, 198, 18-21.
26. Gelernter, J., Kranzler, H., & Cubells, J. F. (1997). Serotonin transporter protein (slc6a4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Human Genetics, 101, 243-246.
27. Glatt, C. E., & Freimer, N. B. (2002). Association analysis of candidate genes for neuropsychiatric disease: The perpetual campaign. Trends in Genetics, 18, 307-312.
28. Hare, R. D., Hart, S. D., & Harpur, T. J. (1991). Psychopathy and the DSM-IV criteria for antisocial personality disorder. Journal of Abnormal Psychology, 100, 391-398.
29. Hariri, A. R., Bookheimer, S. Y., & Mazziotta, J. C. (2000). Modulating emotional responses: Effects of a neocortical network on the limbic system. Neuroreport, 11, 43-48.
30. Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives in General Psychiatry, 62, 146-152.
31. Hariri, A. R., Drabant, E. M., & Weinberger, D. R. (2006). Imaging genetics: Perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biological Psychiatry, 59, 888-897.
32. Hariri, A. R., Mattay, V. S., Tessitore, A., Fera, F., Smith, W. G., & Weinberger, D. R. (2002). Dextroamphetamine modulates the response of the human amygdala. Neuropsychopharmacology, 27, 1036-1040.
33. Hariri, A. R., Mattay, V. S., Tessitore, A., Fera, F., & Weinberger, D. R. (2003). Neocortical modulation of the amygdala response to fearful stimuli. Biological Psychiatry, 53, 494-501.
34. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400-403.
35. Hariri, A. R., Tessitore, A., Mattay, V. S., Fera, F., & Weinberger, D. R. (2002). The amygdala response to emotional stimuli: A comparison of faces and scenes. Neuroimage, 17, 317-323.
36. Hariri, A. R., & Weinberger, D. R. (2003a). Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes, Brain and Behavior, 2, 314-349.
37. Hariri, A. R., & Weinberger, D. R. (2003b). Imaging genomics. British Medical Bulletin, 65, 259-270.
38. Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D., et al. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 2621-2624.
39. Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., et al. (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience, 8, 20-21.
40. Heinz, A., Higley, J. D., Gorey, J. G., Saunders, R. C., Jones, D. W., Hommer, D., et al. (1998). In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. American Journal of Psychiatry, 155, 1023-1028.
41. Heinz, A., Jones, D. W., Bissette, G., Hommer, D., Ragan, P., Knable, M., et al. (2002). Relationship between cortisol and serotonin metabolites and transporters in alcoholism. Pharmacopsychiatry, 35, 127-134.
42. Heinz, A., Jones, D. W., Mazzanti, C., Goldman, D., Ragan, P., Hommer, D., et al. (2000). A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biological Psychiatry, 47, 643-649.
43. Holmes, A., & Hariri, A. R. (2003). The serotonin transporter gene-linked polymorphism and negative emotionality: Placing single gene effects in the context of genetic background and environment. Genes, Brain and Behavior, 2, 332-335.
44. Holmes, A., Lit, Q., Murphy, D. L., Gold, E., & Crawley, J. N. (2003). Abnormal anxiety-related behavior in serotonin transporter null mutant mice: The influence of genetic background. Genes, Brain and Behavior, 2, 365-380.
45. Katsuragi, S., Kunugi, H., Sano, A., Tsutsumi, T., Isogawa, K., Nanko, S., et al. (1999). Association between serotonin transporter gene polymorphism and anxiety-related traits. Biological Psychiatry, 45, 368-370.
46. Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J. H., et al. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences of the United States of America, 101, 17316-17321.
47. Keightley, M. L., Winocur, G., Graham, S. J., Mayberg, H. S., Hevenor, S. J., & Grady, C. L. (2003). An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuli. Neuropsychologia, 41, 585-596.
48. Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication. Archives in General Psychiatry, 62, 529-535.
49. Kim-Cohen, J., Caspi, A., Moffitt, T. E., Harrington, H., Milne, B. J., & Poulton, R. (2003). Prior juvenile diagnoses in adults with mental disorder: Developmental follow-back of a prospective-longitudinal cohort. Archives in General Psychiatry, 60, 709-717.
50. Kreek, M. J., & Koob, G. F. (1998). Drug dependence: Stress and dysregulation of brain reward pathways. Drug and Alcohol Dependence, 51, 23-47.
51. LaForge, K. S., Yuferov, V., & Kreek, M. J. (2000). Opioid receptor and peptide gene polymorphisms: Potential implications for addictions. European Journal of Pharmacology, 410, 249-268.
52. Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., et al. (2001). Initial sequencing and analysis of the human genome. Nature, 409, 860-921.
53. Lange, K., Williams, L. M., Young, A. W., Bullmore, E. T., Brammer, M. J., Williams, S. C., et al. (2003). Task instructions modulate neural responses to fearful facial expressions. Biological Psychiatry, 53, 226-232.
54. LeDoux, J. E. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23, 155-184.
55. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
56. Lesch, K. P., & Mossner, R. (1998). Genetically driven variation in serotonin uptake: Is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biological Psychiatry, 44, 179-192.
57. Lewis, D. A. (1997). Development of the prefrontal cortex during adolescence: Insights into vulnerable neural circuits in schizophrenia. Neuropsychopharmacology, 16, 385-398.
58. Little, K. Y., McLaughlin, D. P., Zhang, L., Livermore, C. S., Dalack, G. W., McFinton, P. R., et al. (1998). Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and MRNA levels. American Journal of Psychiatry, 155, 207-213.
59. Lucki, I. (1998). The spectrum of behaviors influenced by serotonin. Biological Psychiatry, 44, 151-162.
60. Luthar, S. S., Cicchetti, D., & Becker, B. (2000). The construct of resilience: A critical evaluation and guidelines for future work. Child Development, 71, 543-562.
61. Malhotra, A. K., & Goldman, D. (1999). Benefits and pitfalls encountered in psychiatric genetic association studies. Biological Psychiatry, 45, 544-550.
62. Malison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., et al. (1998). Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biological Psychiatry, 44, 1090-1098.
63. Mayberg, H. S. (2003a). Modulating dysfunctional limbic-cortical circuits in depression: Towards development of brain-based algorithms for diagnosis and optimised treatment. British Medical Bulletin, 65, 193-207.
64. Mayberg, H. S. (2003b). Positron emission tomography imaging in depression: A neural systems perspective. Neuroimaging Clinics of North America, 13, 805-815.
65. Mazzanti, C. M., Lappalainen, J., Long, J. C., Bengel, D., Naukkarinen, H., Eggert, M., et al. (1998). Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Archives in General Psychiatry, 55, 936-940.
66. Meaney, M. J., & Szyf, M. (2005). Environmental programming of stress responses through DNA methylation: Life at the interface between a dynamic environment and a fixed genome. Dialogues in Clinical Neuroscience, 7, 103-123.
67. Melke, J., Landen, M., Baghei, F., Rosmond, R., Holm, G., Bjorntorp, P., et al. (2001). Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women. American Journal of Medical Genetics, 105, 458-463.
68. Meyer-Lindenberg, A., Hariri, A. R., Munoz, K. E., Mervis, C. B., Mattay, V. S., Morris, C. A., et al. (2005). Neural correlates of genetically abnormal social cognition in williams syndrome. Nature Neuroscience, 8, 991-993.
69. Moldin, S. O., & Gottesman, II. (1997). At issue: Genes, experience, and chance in schizophrenia - Positioning for the 21st century. Schizophrenia Bulletin, 23, 547-561.
70. Moreno, F. A., Rowe, D. C., Kaiser, B., Chase, D., Michaels, T., Gelernter, J., et al. (2002). Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Molecular Psychiatry, 7, 213-216.
71. Munafo, M. R., Clark, T., & Flint, J. (2005). Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Molecular Psychiatry, 10, 415-419.
72. Murphy, D. L., Andrews, A. M., Wichems, C. H., Li, Q., Tohda, M., & Greenberg, B. (1998). Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. Journal of Clinical Psychiatry, 59(Suppl. 15), 4-12.
73. Nakamura, K., Kawashima, R., Nagumo, S., Ito, K., Sugiura, M., Kato, T., et al. (1998). Neuroanatomical correlates of the assessment of facial attractiveness. Neuroreport, 9, 753-757.
74. Narumoto, J., Yamada, H., Iidaka, T., Sadato, N., Fukui, K., Itoh, H., et al. (2000). Brain regions involved in verbal or non-verbal aspects of facial emotion recognition. Neuroreport, 11, 2571-2576.
75. Neumeister, A., Konstantinidis, A., Stastny, J., Schwarz, M. J., Vitouch, O., Willeit, M., et al. (2002). Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Archives in General Psychiatry, 59, 613-620.
76. Patkar, A. A., Berrettini, W. H., Mannelli, P., Gopalakrishnan, R., Hoehe, M. R., Bilal, L., et al. (2004). Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers. Psychiatry and Genetics, 14, 25-32.
77. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., et al. (2005). 5HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828-834.
78. Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003a). Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biological Psychiatry, 54, 504-514.
79. Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003b). Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry, 54, 515-528.
80. Plomin, R., Owen, M. J., & McGuffin, P. (1994). The genetic basis of complex human behaviors. Science, 264, 1733-1739.
81. Pohorecky, L. A. (1990). Interaction of ethanol and stress: Research with experimental animals - An update. Alcohol and Alcoholism, 25, 263-276.
82. Pohorecky, L. A. (1991). Stress and alcohol interaction: An update of human research. Alcoholism and Clinical Experimental Research, 15, 438-459.
83. Reif, A., & Lesch, K. P. (2003). Toward a molecular architecture of personality. Behavioural Brain Research, 139, 1-20.
84. Rosenkranz, J. A., Moore, H., & Grace, A. A. (2003). The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli. Journal of Neuroscience, 23, 11054-11064.
85. Rutter, M., Kim-Cohen, J., & Maughan, B. (2006). Continuities and discontinuities in psychopathology between childhood and adult life. Journal of Child Psychology and Psychiatry, 47, 276-295.
86. Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene-environment interplay and psychopathology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry and Allied Disciplines, 47, 226-261.
87. Sadikot, A. F., & Parent, A. (1990). The monoaminergic innervation of the amygdala in the squirrel monkey: An immunohistochemical study. Neuroscience, 36, 431-447.
88. Schinka, J. A., Busch, R. M., & Robichaux-Keene, N. (2004). A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Molecular Psychiatry, 9, 197-202.
89. Schuckit, M. A. (1998). Biological, psychological and environmental predictors of the alcoholism risk: A longitudinal study. Journal of the Studies on Alcohol, 59, 485-494.
90. Schwartz, C. E., Wright, C. I., Shin, L. M., Kagan, J., & Rauch, S. L. (2003). Inhibited and uninhibited infants "grown up": Adult amygdalar response to novelty. Science, 300, 1952-1953.
91. Scott, S., Knapp, M., Henderson, J., & Maughan, B. (2001). Financial cost of social exclusion: Follow up study of antisocial children into adulthood. British Medical Journal, 323(7306), 191-195.
92. Sen, S., Burmeister, M., & Ghosh, D. (2004). Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics, 127B, 85-89.
93. Shioe, K., Ichimiya, T., Suhara, T., Takano, A., Sudo, Y., Yasuno, F., et al. (2003). No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by pet. Synapse, 48, 184-188.
94. Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002). Can't shake that feeling: Event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biological Psychiatry, 51, 693-707.
95. Smith, H. R., Daunais, J. B., Nader, M. A., & Porrino, L. J. (1999). Distribution of [3H]citalopram binding sites in the nonhuman primate brain. Annals of the New York Academy of Science, 877, 700-702.
96. Tessitore, A., Hariri, A. R., Fera, F., Smith, W. G., Chase, T. N., Hyde, T. M., et al. (2002). Dopamine modulates the response of the human amygdala: A study in Parkinson's disease. Journal of Neuroscience, 22, 9099-9103.
97. van Dyck, C. H., Malison, R. T., Staley, J. K., Jacobsen, L. K., Seibyl, J. P., Laruelle, M., et al. (2004). Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. American Journal of Psychiatry, 161, 525-531.
98. Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., et al. (2001). The sequence of the human genome. Science, 291, 1304-1351.
99. Viding, E., Blair, R. J., Moffitt, T. E., & Plomin, R. (2005). Evidence for substantial genetic risk for psychopathy in 7-year-olds. Journal of Child Psychology and Psychiatry and Allied Disciplines, 46, 592-597.
100. Wand, G. S., McCaul, M., Yang, X., Reynolds, J., Gotjen, D., Lee, S., et al. (2002). The mu-opioid receptor gene polymorphism (a118g) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology, 26, 106-114.
101. Whale, R., Clifford, E. M., & Cowen, P. J. (2000). Does mirtazapine enhance serotonergic neurotransmission in depressed patients? Psychopharmacology (Berlin), 148, 325-326.
102. Willeit, M., Praschak-Rieder, N., Neumeister, A., Pirker, W., Asenbaum, S., Vitouch, O., et al. (2000). [123I]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder. Biological Psychiatry, 47, 482-489.