[123I]-β-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder

Biological Psychiatry

Volumn 47, Issue 6, 1999, Pages 482-489

  Willeit, Matthäus ^a   Praschak Rieder, Nicole ^a   Neumeister, Alexander ^a   Pirker, Walter ^a   Asenbaum, Susanne ^a   Vitouch, Oliver ^a   Tauscher, Johannes ^a   Hilger, Eva ^a   Stastny, Jürgen ^a   Brücke, Thomas ^a   Kasper, Siegfried ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

CIT; Depression; Seasonal affective disorder; Serotonin; Serotonin transporter; SPECT

Indexed keywords

2 BETA CARBOMETHOXY 3 BETA (4 IDOPHENYL)TROPANE; COCAINE DERIVATIVE; LIGAND; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; COCAINE; DRUG DERIVATIVE; SEROTONIN;

ADULT; AFFECTIVE NEUROSIS; ARTICLE; BINDING SITE; BRAIN REGION; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPOTHALAMUS; MALE; PATHOGENESIS; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS; BRAIN; MAJOR DEPRESSION; METABOLISM; MIDDLE AGED; SCINTISCANNING; SEASONAL AFFECTIVE DISORDER; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; BIOLOGICAL TRANSPORT; BRAIN; COCAINE; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; MALE; MIDDLE AGED; SEASONAL AFFECTIVE DISORDER; SEROTONIN; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0034652809     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00293-0     Document Type: Article

References (47)

1. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. 1994;American Psychiatric Press, Washington, DC.
2. 3H] paroxetine binding to serotonin uptake sites in human brain tissue. Brain Res. 486:1989;261-268.
3. Barker EL, Blakely RD (1995): Norepinephrine and serotonin transporters: Molecular targets of antidepressant drugs. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology, Fourth Generation of Progress. New York: Raven Press, 321-333.
4. 125I]RTI 55 to dopamine and serotonin transporters in the rat brain. Synapse. 12:1992;27-36.
5. Brewerton T.D., Berrettini W.H., Nurnberger J.I. Jr, Linnoila M. Analysis of seasonal fluctations of CSF monoamine metabolites and neuropeptides in normal controls. Psychiatry Res. 23:1988;257-265.
6. 123I]-β-CIT. Binding kinetics in the human brain. J Neural Transm. 94:1993;137-146.
7. Cagampang F.R., Inouye S.T. Diurnal and circadian changes of serotonin in the suprachiasmatic nuclei Regulation by light and an endogenous pacemaker . Brain Res. 639:1994;175-179.
8. Carlsson A., Svennerholm L., Winblad D. Seasonal and circadian monoamine variations in human brains examined post-mortem. Acta Psychiatr Scand. 61:1980;75-83.
9. 11C]-β-CIT binding to monoamine transporters in the monkey and human brain. Synapse. 16:1994;93-103.
10. Garcia-Borreguero D., Jacobsen F.M., Murphy D.L., Joseph-Vanderpool J.R., Chiara A., Rosenthal N.E. Hormonal responses to the administration of m-chlorophenylpiperazine in patients with seasonal affective disorder and controls. Biol Psychiatry. 37:1995;740-749.
11. 123I]-β-CIT. Eur J Pharmacol. 299:1991;369-370.
12. 123I]-β-CIT SPECT imaging in primate brain (abstract). J Nucl Med. 39:1998;42.
13. Kasper S (1991): Jahreszeit und Befindlichkeit in der Allgemeinbevölkerung. Eine Mehrebenenuntersuchung zur Epidemiologie, Biologie und therapeutischen Beeinflussbarkeit (Lichttherapie) saisonaler Befindlichkeitsschwankungen. In: Hippius H, Janzarik W, Müller C, editors. Monographien aus dem Gesamtgebiete der Psychiatrie. New York: Springer-Verlag, 135-136.
14. Kasper S, Neumeister A, Praschak-Rieder N, Ruhrmann S, Hesselmann B (1996): Serotonergic mechanisms in the pathophysiology and treatment of seasonal affective disorder. In: Holick MF, editor. Biologic Effects of Light 1995. Proceedings of a Symposium, Atlanta, USA, October 8-11, 1995. Berlin: de Gruyter, 325-331.
15. 3H-paroxetine to blood platelets in healthy volunteers Indication for a gender difference . Biol Psychiatry. 28:1990;509-517.
16. Lam R.W., Gorman C.P., Michalon M., Steiner M., Levitt A.J., Corral M.R., et al. A multi-centre, placebo-controlled study of fluoxetine in seasonal affective disorder. Am J Psychiatry. 152:1995;1765-1770.
17. Lam R.W., Zis A.P., Grewal A., Delgado P.L., Charney D.S., Krystal J.H. Effects of tryptophan depletion in patients with seasonal affective disorder in remission after light therapy. Arch Gen Psychiatry. 53:1996;41-44.
18. 123I]-β-CIT pharmacological characterization of brain uptake in nonhuman primates . Synapse. 13:1993;295-309.
19. 123I]-β-CIT binding to dopamine transporters in healthy human subjects. J Cereb Blood Flow Metab. 14:1994;982-994.
20. Lesch K.P., Aulakh C.S., Wolozin B.L., Tolliver T.J., Hill J.L., Murphy D.L. Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Mol Brain Res. 17:1993;31-35.
21. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of axiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1996;1527-1531.
22. Little K.Y., McLaughlin D.P., Zhang L., Livermore C.S., Dalack G.W., McFinton P.R., et al. Cocaine, ethanole, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry. 155:1998;207-213.
23. Losonczy M.F., Mohs R.C., Davils K.L. Seasonal variations of human lumbar C.S.F. neurotransmitter metabolite concentrations. Psychiatry Res. 12:1984;79-87.
24. 123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomograpy. Biol Psychiatry. 44:1998;1090-1098.
25. Mellerup E.T., Errebo I., Molin J., Plenge P., Dam H. Platelet paroxetine binding and light therapy in winter depression. J Affect Disord. 29:1993;11-15.
26. Neumaier J.F., Boot D.C., Hamblin M.W. Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus. Neuropsychopharmacology. 5:1996;515-522.
27. Neumeister A., Praschak-Rieder N., Hesselmann B., Rao M.L., Glück J., Kasper S. Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy. Arch Gen Psychiatry. 54:1998;133-138.
28. Neumeister A., Praschak-Rieder N., Hesselmann B., Vitouch O., Rauh M., Barocka A., et al. Effects of tryptophan depletion in fully remitted patients with seasonal affective disorder during summer. Psychol Med. 28:1997;257-264.
29. Neumeyer J.L., Tamangnan G., Wang S., Gao Y., Milius R.A., Kula N.S., Baldessarini R.J. N-substituted analogs of 2-β-carbomethoxy-3-β-(4′-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. J Med Chem. 39:1996;543-548.
30. 123I]-β-CIT) High affinity SPECT radiotracer of monoamine reuptake sites in brain . J Med Chem. 34:1991;3144-3146.
31. 2+ response, and 5-HT content in winter seasonal affective disorder. Biol Psychiatry. 36:1994;458-466.
32. Pirker W, Asenbaum S, Hauk M, Kandlhofer S, Tauscher J, Willeit M, et al (in press): Imaging serotonin and dopamine transporters with iodine-123-β-CIT SPECT: Binding kinetics and effects of normal aging. J Nucl Med.
33. Pirker W., Asenbaum S., Kasper S., Walter H., Angelberger P., Koch G., et al. β-CIT SPECT demonstrates blockade of 5-HT uptake sites by citalopram in the human brain in vivo. J Neural Transm. 100:1995;247-256.
34. Rosenthal N.E., Bradt G.H., Wehr T.A. Seasonal Pattern Assessment Questionnaire. 1987;National Institute of Mental Health, Washington, DC.
35. Rosenthal NE, Genhardt M, Sack DA, Skwerer RG, Wehr TA (1987): Seasonal affective disorder: Relevance for treatment and research of bulimia. In: Hudson JI, Pope HG, editors. Psychobiology of Bulimia. Washington, DC: American Psychiatric Press, 226-228.
36. Rosenthal N.E., Mazzanti C.M., Barnett R.L., Hardin T., Turner E.H., Lam G.K., et al. Short serotonin transporter gene regulatory region An allele for seasonality and a possible risk factor for seasonal affective disorder . Mol Psychiatry. 3:1998;175-177.
37. Rosenthal N.E., Sack D.A., Gillin J.C., Lewy A.J., Goodwin F.K., Davenport Y., et al. Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry. 41:1984;72-80.
38. Sakamoto K., Nakadaira S., Kamo K., Kamo T., Takasashi K. A longitudinal follow-up study of seasonal affective disorder. Am J Psychiatry. 152:1995;862-868.
39. Schwartz P.J., Murphy D.L., Wehr T.A., Garcia-Borreguero D., Oren D.A., Moul D.E., et al. Effects of mCCP infusions in patients with seasonal affective disorder and healthy control subjects Diurnal responses and nocturnal regulatory mechanisms . Arch Gen Psychiatry. 54:1997;375-385.
40. 125I]RTI-55 In vitro binding and autoradiographic characterization . J Neurochem. 62:1994;549-556.
41. 19F magnetic resonance spectroscopy. Am J Psychiatry. 155:1998;380-384.
42. Talairach J., Tournoux P. Coplanar Stereotaxic Atlas of the Human Brain. 1988;Thieme, New York.
43. 3H]-Nisoxetine A radioligand for quantification of norepinephrine uptake sites by autoradiography or homogenate binding . J Pharmacol Exp Ther. 260:1992;427-436.
44. 123I]-β-CIT SPECT in drug free depressed patients with seasonal affective disorder. Biol Psychiatry. 42:(suppl 1):1997;168.
45. Williams J.D., Link M.J., Rosenthal N.E., Terman M. Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorder Version (SIGH-SAD). 1988;New York Psychiatric Institute, New York.
46. Wirtz Justice A., Richter R. Seasonality in biochemical determinations A source of variance and a clue to the temporal incidence of affective illness . Psychiatry Res. 1:1979;53-60.
47. Yatham L.N., Lam R.W., Zis A.P. Growth hormone response to sumatriptan (5-HT1D agonist) challenge in seasonal affective disorder Effects of light therapy . Biol Psychiatry. 42:1997;24-29.