Relationship between seroton in transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers

Psychiatric Genetics

Volumn 14, Issue 1, 2004, Pages 25-32

  Patkar, Ashwin A ^a   Berrettini, Wade H ^b   Mannelli, Paolo ^a   Gopalakrishnan, Raman ^a   Hoehe, Margret R ^c   Bilal, Louai ^a   Weinstein, Stephen ^a   Vergare, Michael J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Cocaine; Serotonin; Serotonin transporter; Serotonin transporter gene

Indexed keywords

PAROXETINE; SEROTONIN TRANSPORTER; CARRIER PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; SLC6A4 PROTEIN, HUMAN;

ADULT; AFRICAN AMERICAN; ARTICLE; BASE PAIRING; COCAINE DEPENDENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; ALLELE; BLOOD; COMPARATIVE STUDY; ETHNOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; THROMBOCYTE;

INSERTION SEQUENCES;

ADULT; AFRICAN AMERICANS; ALLELES; BLOOD PLATELETS; CARRIER PROTEINS; COCAINE-RELATED DISORDERS; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; PAROXETINE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 1642271808     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-200403000-00004     Document Type: Article

References (51)

1. Adami H, Elliott A, Zetlmeisl M, McMahon R, Thaker G (2002). Use of telephone screens improves efficiency of healthy subject recruitment. Psychiatry Res 113:295-301.
2. Anderson GM, Gutknecht L, Cohen DJ, Brailly-Tabard S, Cohen JH, Ferrari P, et al. (2002). Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. Mol Psychiatry 7: 831-836.
3. Arranz B, Rosel P, Sarro S, Zaldivar E, Cano R, Navarro M, et al. (1999). Platelet serotonergic binding sites in alcohol-dependent patients. Alcohol Alcohol 34:726-732.
4. Baumann MH, Rothman RB (1998). Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans. Biol Psychiatry 44:578-591.
5. Beck AT, Steer RA (1987). Beck Depression Inventory. San Antonio, TX: The Psychological Corporation. Brace and Jovanovich, Harcourt.
6. Berrettini WH, Persico AM (1996). Dopamine D2 receptor gene polymorphisms and vulnerability to substance abuse in African-Americans. Biol Psychiatry 40:144-147.
7. Buydens-Branchey L, Branchey M, Fergeson P, Hudson J, McKemin P (1997). The meta-chlorophenylpiperazine challenge test in cocaine addicts: hormonal and psychological responses. Biol Psychiatry 41:1071-1086.
8. Castanon N, Scearce-Levie K, Lucas JJ, Rocha B, Hen R (2000). Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists. Pharmacol Biochem Behav 67:559-566.
9. Cohen J (1988). Statistical Power Analysis for the Social Sciences. New York: Academic Press.
10. Cunningham KA, Bradberry CW, Chang AS, Reith ME (1996). The role of serotonin in the actions of psychostimulants: molecular and pharmacological analyses. Behav Brain Res 73:93-102.
11. First MB, Spitzer RL, Gibbon M, Williams JBW (1997). Structured Clinical Interview for DSM-IV Disorders (SCID-IV). Washington, DC: American Psychiatric Press.
12. Flattem NL, Blakely RD (2000). Modified structure of the human serotonin transporter promoter. Mol Psychiatry 5:110-115.
13. Gelernter J, Pakstis AJ, Kidd KK (1995). Linkage mapping of serotonin transporter gene SLC6A4 on chromosome 17. Hum Genet 95:677-680.
14. Graham D, Langer SZ (1992). Advances in sodium-ion coupled biogenic amine transporters. Life Sci 51:631-645.
15. Greenberg BD, Tolliver TJ, Huang S-J, Li Q, Bengel D, Murphy DL (1999). Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88:83-87.
16. Handelsman L, Kahn RS, Sturiano C, Rinaldi PJ, Gabriel S, Schneidler JP, et al. (1998). Hostility is associated with a heightened prolactin response to meta-chlorophenylpiperazine in abstinent cocaine addicts. Psychiatry Res 80: 1-12.
17. Hanna GL, Himle JA, Curtis GC, Koram DQ, Veenstra-VanderWeele J, Leventhal BL, et al. (1998). Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder. Neuropsychopharmacology 18:102-111.
18. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, et al. (1996). Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
19. Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D, et al. (2000). A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 47:643-649.
20. Heidbreder CA, Oertle T, Feldon J (1999). Dopamine and serotonin imbalances in the left anterior cingulated and pyriform cortices following the repeated intermittent administration of cocaine. Neuroscience 89:701-715.
21. Humblot N, Thiriet N, Gobaille S, Aunis D, Zwiller J (1998). The serotonergic system modulates the cocaine-induced expression of the immediate early genes egr-1 and c-fos in rat brain. Ann NY Acad Sci 844:7-20.
22. Jacobsen LK, Staley JK, Malison RT, Zoghbi SS, Seibyl JP, Kosten TR, et al. (2000). Elevated central serotonin transporter binding availabilty in acutely abstinent cocaine-dependent patients. Am J Psychiatry 157: 1134-1140.
23. Kaiser R, Muller-Oerlinghausen B, Filler D, Tremblay PB, Berghofer A, Roots I, et al. (2002). Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter. Am J Med Genet 114:323-328.
24. Kleven MS, Koek W (1998). Discriminative properties of cocaine: enhancement by monamine reuptake blockers. J Pharmacol Exper Ther 284:1015-1025.
25. Kranzler H, Lappalainen J, Nellissery M, Gelernter J (2002). Association study of alcoholism subtypes with a functional polymorphism in the serotonin transporter protein gene. Alcohol Clin Exp Res 26:1330-1335.
26. Lerman C, Shields PG, Audrain J, Main D, Cobb B, Boyd NR, Caporaso N (1998). The role of the serotonin transporter gene in cigarette smoking. Cancer Epidemiol Biomarkers Prev 7:253-255.
27. Lesch K-P, Wolozin BL, Murphy DL, Reiderer P (1993). Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem 60:2319-2322.
28. Lesch K-P, Balling U, Gross J, Wolozin BL, Riederer P, Murphy DL (1994). Organization of the human serotonin transporter gene. J Neural Transm 95:157-162.
29. Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. (1996). Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
30. Lichtermann D, Hranilovic D, Trixler M, Franke P, Jernej B, Delmo CD, et al. (2000). Support for an association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcohol dependence. Am J Psychiatry 157:2045-2047.
31. Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, McFinton PR, et al. (1998). Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 155:207-213.
32. Lowry O, Rosebrough NJ, Farr AL, Randall RJ (1951). Protein measurement with the Folin Phenol reagent. J Biol Chem 193:265-275.
33. McGue M, Pickens RW, Svikis DS (1992). Sex and age effects on the inheritance of alcohol problems: a twin study. J Abnormal Psychol 101:3-17.
34. McLellan AT, Luborsky L, Cacciola J, Kushner H, Peters L, Smith I, et al. (1992). The fifth edition of the Addiction Severity Index: cautions, additions and normative data. J Nervous Mental Dis 168:26-33.
35. McMahon LR, Cunningham KA (2001). Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. J Pharmacol Exp Ther 297:357-363.
36. Mellerup E, Bennike B, Bolwig T, Dam H, Hasholt L, Jorgensen MB, et al. (2001). Platelet serotonin transporters and the transporter gene in control subjects unipolar patients and bipolar patients. Acta Psychiatr Scand 103:229-233.
37. Miller SA, Dykes D, Plessky HF (1988). A simple salting out procedure for extracting DNA from human nucleated cells (Letter). Nucl Acids Res 16:1215.
38. Naylor L, Dean B, Pereira A, Mackinnon A, Kouzmenko A, Copolov D (1998). No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter in human hippocampus. Mol Med 4:671-674.
39. Nemeroff CB, Knight DL, Franks J, Craighead WE, Krishnan KR (1994). Further studies on platelet serotonin transporter binding in depression. Am J Psychiatry 151:1623-1625.
40. 2+ response and 5-HT, content in winter seasonal affective disorder. Biol Psychiatry 36:458-466.
41. Patkar AA, Berrettini WH, Hoehe M, Hill KP, Sterling RC, Gottheil E, Weinstein SP (2001). Serotonin transporter (5-HTT) gene polymorphisms and cocaine dependence among African-American individuals. Addict Biol 6:337-345.
42. Patkar AA, Gottheil E, Berrettini WH, Thornton CC, Hill KP, Weinstein SP (2003). Platelet tritiated paroxetine binding and treatment outcome among African-American cocaine dependent individuals. J Addict Dis 22:79-92.
43. 3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity. Psychiatry Res 96:51-61.
44. Sander T, Harms H, Lesch K-P, Defeu P, Kuhn S, Hoehe M, et al. (1997). Association analysis of regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res 21:1356-1359.
45. Schloss P, Williams DC (1998). The serotonin transporter: a primary target for antidepressant drugs. J Psychopharmacol 12:116-121.
46. Schuckit MA, Mazzanti C, Smith TL, Ahmed U, Radel M, Iwata N, et al. (1999). Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol Psychiatry 45:647-651.
47. 125I]RTI-55: in vitro binding and characterization. J Neurochem 62:549-556.
48. Stoltenberg SF, Burmeister M (2000). Recent progress in psychiatric genetics-some hope but no hype. Hum Mol Genet 12:927-935.
49. Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA, et al. (2002). Serotonin transporter promoter polymorphism, peripheral indices of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 114:230-234.
50. Willeit M, Stastny J, Pirker W, Praschak-Rieder N, Neumeister A, Asenbaum S, et al. (2001). No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism. Biol Psychiatry 50:8-12.
51. +/Cl-dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems. Pharmacol Ther 92:21-55.