Gene-environment interaction analysis of serotonin system markers with adolescent depression

Molecular Psychiatry

Volumn 9, Issue 10, 2004, Pages 908-915

  Eley, T C ^a   Sugden, K ^a   Corsico, A ^a   Gregory, A M ^a   Sham, P ^a   McGuffin, P ^a   Plomin, R ^a   Craig, I W ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Adolescence; Depression; Gene environment interaction; Monoamine oxidase A; Serotonin receptors; Serotonin transporter; Tryptophan hydroxylase

Indexed keywords

SEROTONIN;

5HTT GENE; 5HTTLPR GENE; ADOLESCENCE; ADOLESCENT; ADULT; CLINICAL FEATURE; CONFERENCE PAPER; DEPRESSION; DISEASE MARKER; DNA DETERMINATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FAMILY; FEMALE; GENE; GENE ENVIRONMENT INTERACTION; GENETIC HETEROGENEITY; GENETIC RISK; GENOTYPE; HEREDITY; HIGH RISK POPULATION; HTR2A GENE; HTR2C GENE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MAOA GENE; MARKER GENE; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; SEROTONINERGIC SYSTEM; SEX DIFFERENCE; SUICIDAL BEHAVIOR; TPH GENE; TPH2 GENE;

ADOLESCENT; ADOLESCENT PSYCHOLOGY; ADULT; BIOLOGICAL MARKERS; CHILD; DEPRESSION; ENVIRONMENT; FAMILY HEALTH; FEMALE; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MONOAMINE OXIDASE; NERVE TISSUE PROTEINS; PROMOTER REGIONS (GENETICS); QUESTIONNAIRES; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RISK; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS; TRYPTOPHAN HYDROXYLASE;

EID: 6044228097     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001546     Document Type: Conference Paper

References (49)

1. Plomin R, DeFries JC, Craig IW, McGuffin P. Behavioral Genetics in the Postgenomic Era. American Psychological Association: Washington, DC, 2003.
2. Rice F, Harold G, Thaper A. The genetic aetiology of childhood depression: a review. J Child Psychol Psychiatry Allied Discip 2002; 43: 65-80.
3. Elcy TC, Stevenson J. Specific life events and chronic experiences differentially associated with depression and anxiety in young twins. J Abnorm Child 2000; 28: 383-394.
4. Silberg J, Rutter M, Neale M, Eaves L. Genetic moderation of environmental risk for depression and anxiety in adolescent girls. Br J Psychiatry 2001; 179: 116-121.
5. Eley TC, Liang H, Plomin R, Sham P, Sterne A, Williamson R et al. Parental vulnerability, family environment and their interactions as predictors of depressive symptoms in adolescents. J Am Acad Child Adolescent Psychiatry 2004; 43: 298-306.
6. Claxton AJ, Li Z, McKendrick J. Selective serotonin reuptake inhibitor treatment in the UK: risk of relapse or recurrence of depression. Br J Psychiatry 2000; 177: 163-168.
7. Hrdina PD, Demeter E, Vu TB, Sotonyi P, Palkovits M. 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain Res 1993; 614: 37-44.
8. Hrdina PD, Bakish D, Chudzik J, Ravindran A, Lapierre YD. Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. J Psychiatry Neurosci 1995; 20: 11-19.
9. Lesch KP, Bengel D, Heils A, Zhang Sabol S, Greenburg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
10. Anguelova MB. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003; 8: 646-653.
11. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-389.
12. Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet 2000; 96: 56-60.
13. Geijer T, Frisch A, Persson ML, Wasserman D, Rockah R, Michaelovsky E et al. Search for association between suicide attempt and serotonergic polymorphisms. Psychiatr Genet 2000; 10: 19-26.
14. Papolos DF, Yu YM, Rosenbaum E, Lachman HM, Modulation of learned helplessness by 5-hydroxytryptamine2A receptor antisense oligodeoxynucleotides. Psychiatry Res 1996; 63: 197-203.
15. Turecki G, Briere R, Dewar K, Antonetti T, Lesage AD, Seguin M et al. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide [comment]. Am J Psychiatry 1999; 156: 1456-1458.
16. Turecki G, Sequeira A, Gingras Y, Seguin M, Lesage A, Tousignant M et al. Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. Am J Med Genet 2003; 118B: 36-40.
17. Lerer B, Macciardi F, Segman RH, Adolfsson R, Blackwood D, Blairy S et al. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Mol Psychiatry 2001; 6: 579-585.
18. Gutierrez B, Arias B, Papiol S, Rosa A, Fananas L. Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder. Neurosci Lett 2001; 309: 135-137.
19. Fehr C, Schleicher A, Szegedi A, Anghelescu I, Klawe C, Hiemke C et al. Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Prog Neuro-Psychopharmacol Biol Psychiatry 2001; 25: 965-982.
20. Schulze TG, Müller DJ, Krauss H, Scherk H, Ohlraun S, Syagailo et al. Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. Am J Med Genet 2000; 96: 801-803.
21. Ho LW, Furlong RA, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder. Am J Med Genet 2000; 96: 36-J2.
22. Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D et al. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 1999; 8: 621-624.
23. Eley TC, Tahir E, Angleitner A, Harriss K, McClay J, Plomin R et al. Association analysis of MAOA and COMT with Neuroticism assessed by peers. Neuropsychiatr Genet 2003; 120B: 90-96.
24. Du L, Bakish D, Hrdina PD. Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder. J Affect Disord 2001; 65: 37-44.
25. Serretti A, Zanardi R, Cusin C, Rossini D, Lorenzi C, Smeraldi E. Tryptophan hydroxylase gene associated with paroxetine antidepressant activity. Eur Neuropsychopharmacol 2001; 11: 375-380.
26. Abbar M, Courtet P, Bellivier F, Leboyer M, Boulenger JP, Castelhau D et al. Suicide attempts and the tryptophan hydroxylase gene. Mol Psychiatry 2001; 6: 268-273.
27. Zalsman G, Frisch A, King RA, Pauls DL, Grice DE, Gelernter J et al. Case control and family-based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents. Am J Med Genet 2001; 105: 451-457.
28. Fendrich M, Warner V, Weissman MM. Family risk factors, parental depression, and psychopathology in offspring. Dev Psychol 1990; 26: 40-50.
29. Beidel DC, Turner SM. At risk for anxiety: I. Psychopathology in the offspring of anxious parents. J Am Acad Child Adolescent Psychiatry 1997; 36: 918-924.
30. Eley TC. Depressive symptoms in children and adolescents: etiological links between normality and abnormality: a research note. J Child Psychol Psychiatry 1997; 38: 861-866.
31. Sham PC, Sterne A, Purcell S, Cherny SS, Webster M, Rijsdijk FV et al. GENESiS: creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings. Twin Res 2000; 3: 316-322.
32. Angold A, Costello EJ, Messer SC, Pickles A, Winder F, Silver D. The development of a short questionnaire for use in epidemiological studies of depression in children and adolescents. Int J Methods Psychiatr Res 1995; 5: 1-12.
33. Freeman B, Powell J, Ball DM, Hill L, Craig IW, Plomin R. DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behav Genet 1997; 27: 251-257.
34. Corney R. Development and use of a short self-rating instrument to screen for psychosocial disorder. J R College Practioners 1988; 38: 263-266.
35. Brugha TS, Cragg D. The List of Threatening Experiences: the reliability and validity of a brief life events questionnaire. Acta Psychiatr Scand 1990; 82: 77-81.
36. Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 1997; 101: 243-246.
37. Warren Jr JT, Peacock ML, Rodriguez LC, Fink JK. An MspI polymorphism in the hyman serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis. Hum Mol Genet 1993; 2: 338.
38. Yuan X, Yamada K, Ishiyama-Shigemoto S, Koyama W, Nonaka. Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia 2000; 43: 373-376.
39. Paoloni-Giacobino A, Mouthon D, Lambercy C, Vessaz M, Coutant-Zimmerli S, Rudolph W et al. Identification and analysis of new sequence variants in the human tryptophan hydroxylase (TpH) gene. Mol Psychiatry 2000; 5: 49-55.
40. Walther DJ, Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 2003; 66: 1673-1800.
41. Stata Corporation. STATA. 2002; http://www.stata.com.
42. Nash MW, Sugden K, Huezo-Diaz P, Williamson RJ, Viding E, Sterne A et al. Association analysis of monoamine genes with depression and anxiety-related traits. Am J Med Genet 2003 (in press).
43. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003; 299: 76.
44. Steiner M, Dunn E, Born L. Hormones and mood: from menarche to menopause and beyond. J Affect Disord 2003; 74: 67-83.
45. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297: 400-403.
46. Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch KP et al. Genetic perspectives on the serotonin transporter. Brain Res Bull 2001; 56: 487-J94.
47. Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE et al. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 2002; 7: 118-122.
48. Lesch KP. Neuroticism and serotonin: a developmental genetic perspective. In: Plomin R, DeFries JC, Craig IW, McGuffin P (eds). Behavioral Genetics in the Postgenomic Era. American Psychological Association: Washington, DC, 2003; 389-423.
49. Santarelliu L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S et al. Requirement of hippocampal neurogenesis for the behavioural effects of antidepressants. Science 2003; 301: 805-809.