메뉴 건너뛰기




Volumn 3, Issue 4, 2006, Pages 351-358

Molecular mechanisms of ischemic neuronal cell death - With relevance to Alzheimer's disease

Author keywords

Alzheimer's disease; Cell death; Ischemia; Organelle

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; GLUTAMATE RECEPTOR ANTAGONIST;

EID: 33748446616     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720506778249498     Document Type: Review
Times cited : (10)

References (92)
  • 1
    • 0036734118 scopus 로고    scopus 로고
    • Limitations in the brain repair
    • Snyder EY and Park KI. Limitations in the brain repair. Nat Med 8: 928-930 (2002).
    • (2002) Nat Med , vol.8 , pp. 928-930
    • Snyder, E.Y.1    Park, K.I.2
  • 2
    • 0036735672 scopus 로고    scopus 로고
    • Neuronal replacement from endogenous precursors in the adult brain after stroke
    • Arvidsson A, Collin T, Kirik D, Kokaia Z and Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 8: 963-970 (2002).
    • (2002) Nat Med , vol.8 , pp. 963-970
    • Arvidsson, A.1    Collin, T.2    Kirik, D.3    Kokaia, Z.4    Lindvall, O.5
  • 3
    • 0027058613 scopus 로고
    • Energy metabolism at the cellular level of the CNS
    • Hertz L and Peng L. Energy metabolism at the cellular level of the CNS. Can J Physiol Pharmacol 70: S14 (1992).
    • (1992) Can J Physiol Pharmacol , vol.70
    • Hertz, L.1    Peng, L.2
  • 4
    • 10344255002 scopus 로고
    • Carbohydrate and energy metabolism of the central nervous system: Biochemical approach
    • North-Holland Publishing Company, Amsterdam
    • Bachelard HS. Carbohydrate and energy metabolism of the central nervous system: Biochemical approach. In 'Handbook of Neurology vol 27', North-Holland Publishing Company, Amsterdam, p1 (1976).
    • (1976) Handbook of Neurology Vol 27 , vol.27 , pp. 1
    • Bachelard, H.S.1
  • 5
    • 0016197163 scopus 로고
    • Cerebral infarction: Evolution of histopathological changes after occlusion of a middle cerebral artery in primates
    • Garcia JH and Kamijyo Y. Cerebral infarction: Evolution of histopathological changes after occlusion of a middle cerebral artery in primates. Exp Neurol 33: 408-421 (1974).
    • (1974) Exp Neurol , vol.33 , pp. 408-421
    • Garcia, J.H.1    Kamijyo, Y.2
  • 6
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • Benveniste H, Drejer J, Schousboe A and Diemer NH. Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43: 1369-1374 (1984).
    • (1984) J Neurochem , vol.43 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.H.4
  • 7
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634 (1988).
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 8
    • 0021363366 scopus 로고
    • Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals
    • Chan PH, Schmidley JW, Fishman RA and Longar SM. Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals. Neurology 34: 315-320 (1984).
    • (1984) Neurology , vol.34 , pp. 315-320
    • Chan, P.H.1    Schmidley, J.W.2    Fishman, R.A.3    Longar, S.M.4
  • 9
    • 0033789565 scopus 로고    scopus 로고
    • Free radical pathways in CNS injury
    • Lewen A, Matz P and Chan PH. Free radical pathways in CNS injury. J Neurotrauma 17: 871-890 (2000).
    • (2000) J Neurotrauma , vol.17 , pp. 871-890
    • Lewen, A.1    Matz, P.2    Chan, P.H.3
  • 10
    • 1542328963 scopus 로고    scopus 로고
    • An update on thrombolytic therapy for acute stroke
    • Schellinger PD, Kaste M and Hacke W. An update on thrombolytic therapy for acute stroke. Curr Opin Neurol 17: 69-77 (2004).
    • (2004) Curr Opin Neurol , vol.17 , pp. 69-77
    • Schellinger, P.D.1    Kaste, M.2    Hacke, W.3
  • 11
    • 0030759007 scopus 로고    scopus 로고
    • Brain single-photon emission CT with HMPAO and safety of thrombolytic therapy in acute ischemic stroke
    • Proceedings of the meeting of the SPECT Safe Thrombolysis Study Collaborators and the members of the Brain Imaging Council of the Society of Nuclear Medicine
    • Alexandrov AV, Masdeu JC, Devous MD Sr, Black SE and Grotta JC. Brain single-photon emission CT with HMPAO and safety of thrombolytic therapy in acute ischemic stroke. Proceedings of the meeting of the SPECT Safe Thrombolysis Study Collaborators and the members of the Brain Imaging Council of the Society of Nuclear Medicine. Stroke 28:1830-1834 (1997).
    • (1997) Stroke , vol.28 , pp. 1830-1834
    • Alexandrov, A.V.1    Masdeu, J.C.2    Devous Sr., M.D.3    Black, S.E.4    Grotta, J.C.5
  • 13
    • 10344240894 scopus 로고    scopus 로고
    • Ischemic neuronal cell death and organellae damage
    • Hayashi T and Abe K. Ischemic neuronal cell death and organellae damage. Neurol Res 26: 827-834 (2004).
    • (2004) Neurol Res , vol.26 , pp. 827-834
    • Hayashi, T.1    Abe, K.2
  • 14
    • 0010737535 scopus 로고    scopus 로고
    • Loss of neuronal calcium homeostasis in ischemia
    • (Ed: Welch KMA, Caplan LR, Reis DJ, Siesjo BK and Weir B), Academic Press, San Diego
    • Erecinska M and Silver IA. Loss of neuronal calcium homeostasis in ischemia. In 'Primer on cerebrovascular diseases' (Ed: Welch KMA, Caplan LR, Reis DJ, Siesjo BK and Weir B), Academic Press, San Diego, p178-183 1997.
    • (1997) Primer on Cerebrovascular Diseases , pp. 178-183
    • Erecinska, M.1    Silver, I.A.2
  • 15
    • 0028217760 scopus 로고
    • Ions and energy in mammalian brain
    • Erecinska M and Silver IA. Ions and energy in mammalian brain. Prog Neurobiol 43: 27-71 (1994).
    • (1994) Prog Neurobiol , vol.43 , pp. 27-71
    • Erecinska, M.1    Silver, I.A.2
  • 16
    • 0027517101 scopus 로고
    • + currents that fail to inactivate
    • + currents that fail to inactivate. Trends Neurosci 16: 455-460 (1993).
    • (1993) Trends Neurosci , vol.16 , pp. 455-460
    • Taylor, C.P.1
  • 17
    • 0002788154 scopus 로고    scopus 로고
    • NMDA and AMPA receptor antagonists in global and focal ischemia
    • (Ed: Welch KMA, Caplan LR, Reis DJ, Siesjo BK and Weir B), Academic Press, San Diego
    • Small DL and Buchan AM. NMDA and AMPA receptor antagonists in global and focal ischemia. In 'Primer on cerebrovascular diseases' (Ed: Welch KMA, Caplan LR, Reis DJ, Siesjo BK and Weir B), Academic Press, San Diego, pp. 244-247 (1997).
    • (1997) Primer on Cerebrovascular Diseases , pp. 244-247
    • Small, D.L.1    Buchan, A.M.2
  • 18
    • 0024513668 scopus 로고
    • Phenytoin protects against ischemia-produced neuronal cell death
    • Taft WC, Clifton GL, Blair RE and Delorenzo RJ. Phenytoin protects against ischemia-produced neuronal cell death. Brain Res 483: 143-148 (1989).
    • (1989) Brain Res , vol.483 , pp. 143-148
    • Taft, W.C.1    Clifton, G.L.2    Blair, R.E.3    Delorenzo, R.J.4
  • 19
    • 0342618284 scopus 로고    scopus 로고
    • Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest
    • Crumrine RC, Bergstrand K, Cooper AT, Faison WL, Cooper BR. Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest. Stroke 28: 2230-2236 (1997).
    • (1997) Stroke , vol.28 , pp. 2230-2236
    • Crumrine, R.C.1    Bergstrand, K.2    Cooper, A.T.3    Faison, W.L.4    Cooper, B.R.5
  • 20
    • 0007504744 scopus 로고    scopus 로고
    • Sodium channel antagonists
    • (Ed: Welch KMA, Caplan LR, Reis DJ, Siesjo BK and Weir B), Academic Press, San Diego
    • Meldrum B. Sodium channel antagonists. In 'Primer on cerebrovascular diseases' (Ed: Welch KMA, Caplan LR, Reis DJ, Siesjo BK and Weir B), Academic Press, San Diego, pp. 248-250 (1997).
    • (1997) Primer on Cerebrovascular Diseases , pp. 248-250
    • Meldrum, B.1
  • 21
    • 0023153653 scopus 로고
    • Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischemia
    • Desphande JK, Siesjo BK and Wieloch T. Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischemia. J Cereb Blood Flow Metab 7: 89-95 (1987).
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 89-95
    • Desphande, J.K.1    Siesjo, B.K.2    Wieloch, T.3
  • 22
    • 0344699919 scopus 로고    scopus 로고
    • Cell calcium homeostasis and calcium-related ischemic damage
    • (Ed: Welch KMA, Caplan LR, Reis DJ, Siesjo BK and Weir B), Academic Press, San Diego
    • Siesjo BK and Kristian T. Cell calcium homeostasis and calcium-related ischemic damage. In 'Primer on cerebrovascular diseases' (Ed: Welch KMA, Caplan LR, Reis DJ, Siesjo BK and Weir B), Academic Press, San Diego, pp. 172-178 (1997).
    • (1997) Primer on Cerebrovascular Diseases , pp. 172-178
    • Siesjo, B.K.1    Kristian, T.2
  • 23
    • 0031840150 scopus 로고    scopus 로고
    • Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion
    • Kristian T, Gido G, Kuroda S, Schutz A and Siesjo BK. Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion. Exp Brain Res 120: 503-509 (1998).
    • (1998) Exp Brain Res , vol.120 , pp. 503-509
    • Kristian, T.1    Gido, G.2    Kuroda, S.3    Schutz, A.4    Siesjo, B.K.5
  • 24
    • 0023225212 scopus 로고
    • The therapeutic value of nimodipine in experimental focal cerebral ischemia. Neurological outcome and histopathological findings
    • Germano IM, Bartkowski HM, Cassel ME and Pitts LH. The therapeutic value of nimodipine in experimental focal cerebral ischemia. Neurological outcome and histopathological findings. J Neurosurg 67: 81-87 (1987).
    • (1987) J Neurosurg , vol.67 , pp. 81-87
    • Germano, I.M.1    Bartkowski, H.M.2    Cassel, M.E.3    Pitts, L.H.4
  • 25
    • 0035134235 scopus 로고    scopus 로고
    • Calcium antagonists for ischemic stroke. A systematic review
    • Horn J and Limburg M. Calcium antagonists for ischemic stroke. A systematic review. Stroke 32: 570-576 (2001).
    • (2001) Stroke , vol.32 , pp. 570-576
    • Horn, J.1    Limburg, M.2
  • 26
    • 4344566337 scopus 로고    scopus 로고
    • Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimer's disease
    • Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, et al. Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. Am J Pathol 165: 795-805 (2004).
    • (2004) Am J Pathol , vol.165 , pp. 795-805
    • Veeranna1    Kaji, T.2    Boland, B.3    Odrljin, T.4    Mohan, P.5    Basavarajappa, B.S.6
  • 27
    • 0025320360 scopus 로고
    • Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia
    • Tollefson GD. Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia. Biol Psychiatry 27: 1133-42 (1990).
    • (1990) Biol Psychiatry , vol.27 , pp. 1133-1142
    • Tollefson, G.D.1
  • 28
    • 0026497926 scopus 로고
    • Excitotoxic cell death
    • Choi DW. Excitotoxic cell death. J Neurobiol 23: 1261-1276 (1992).
    • (1992) J Neurobiol , vol.23 , pp. 1261-1276
    • Choi, D.W.1
  • 30
    • 0027495382 scopus 로고
    • AMPA antagonists: Do they hold more promise for clinical stroke trials than NMDA antagonists?
    • Buchan AM, Lesiuk H, Barnes KA, Li H, Huang ZG, Smith KE, et al. AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists? Stroke 24(Suppl): I148-52 (1993).
    • (1993) Stroke , vol.24 , Issue.SUPPL.
    • Buchan, A.M.1    Lesiuk, H.2    Barnes, K.A.3    Li, H.4    Huang, Z.G.5    Smith, K.E.6
  • 31
    • 0023788688 scopus 로고
    • The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat
    • Park CK, Nehls DG, Graham DI, Teasdale GM and McCulloch J. The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann Neurol 24: 543-51 (1988).
    • (1988) Ann Neurol , vol.24 , pp. 543-551
    • Park, C.K.1    Nehls, D.G.2    Graham, D.I.3    Teasdale, G.M.4    McCulloch, J.5
  • 32
    • 0029554339 scopus 로고
    • Clinical pharmacology of CNS 1102 in volunteers
    • Muir KW, Grosset DG and Lees KR. Clinical pharmacology of CNS 1102 in volunteers. Ann N Y Acad Sci. 765: 279-89 (1995).
    • (1995) Ann N Y Acad Sci , vol.765 , pp. 279-289
    • Muir, K.W.1    Grosset, D.G.2    Lees, K.R.3
  • 33
    • 0028500548 scopus 로고
    • The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia
    • Gill R. The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia. Cerebrovasc Brain Metab Rev 6: 225-256 (1994).
    • (1994) Cerebrovasc Brain Metab Rev , vol.6 , pp. 225-256
    • Gill, R.1
  • 34
    • 13444291406 scopus 로고    scopus 로고
    • Paradigm shift in NMDA receptor antagonist drug development: Molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders
    • Lipton SA. Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders. J Alzheimers Dis 6(6 Suppl): S61-74 (2004).
    • (2004) J Alzheimers Dis , vol.6 , Issue.6 SUPPL.
    • Lipton, S.A.1
  • 35
    • 4644368367 scopus 로고    scopus 로고
    • Memantine hydrochloride: Pharmacological and clinical profile
    • Barc
    • Mobius HJ, Stoffler A and Graham SM. Memantine hydrochloride: pharmacological and clinical profile. Drugs Today (Barc) 40: 685-695 (2004).
    • (2004) Drugs Today , vol.40 , pp. 685-695
    • Mobius, H.J.1    Stoffler, A.2    Graham, S.M.3
  • 36
  • 37
    • 0037443605 scopus 로고    scopus 로고
    • Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke
    • Liu S, Liu M, Peterson S, Miyake M, Vallyathan V and Liu KJ. Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke. J Neurosci Res 71: 882-888 (2003).
    • (2003) J Neurosci Res , vol.71 , pp. 882-888
    • Liu, S.1    Liu, M.2    Peterson, S.3    Miyake, M.4    Vallyathan, V.5    Liu, K.J.6
  • 39
    • 11844282198 scopus 로고    scopus 로고
    • Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons
    • Hayashi T, Saito A, Okuno S, Ferrand-Drake M, Dodd RL and Chan PH. Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons. J Cereb Blood Flow Metab 25: 41-53 (2005).
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 41-53
    • Hayashi, T.1    Saito, A.2    Okuno, S.3    Ferrand-Drake, M.4    Dodd, R.L.5    Chan, P.H.6
  • 40
    • 0036138386 scopus 로고    scopus 로고
    • Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation
    • Sugawara T, Noshita N, Lewen A, Gasche Y, Ferrand-Drake M, Fujimura M, et al. Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci 22: 209-217 (2002).
    • (2002) J Neurosci , vol.22 , pp. 209-217
    • Sugawara, T.1    Noshita, N.2    Lewen, A.3    Gasche, Y.4    Ferrand-Drake, M.5    Fujimura, M.6
  • 41
    • 0033789565 scopus 로고    scopus 로고
    • Free radical pathways in CNS injury
    • Lewen A, Matz P and Chan PH. Free radical pathways in CNS injury. J Neurotrauma 17:871-890 (2000).
    • (2000) J Neurotrauma , vol.17 , pp. 871-890
    • Lewen, A.1    Matz, P.2    Chan, P.H.3
  • 42
    • 0000994567 scopus 로고    scopus 로고
    • Oxidative stress: Adaptation, damage, repair and death
    • (Ed: Halliwell B and Gutteridge JMC), Oxford University Press, New York
    • Halliwell B and Gutteridge JMC. Oxidative stress: adaptation, damage, repair and death. In: 'Free radicals in biology and medicine'. (Ed: Halliwell B and Gutteridge JMC), Oxford University Press, New York, (1999).
    • (1999) Free Radicals in Biology and Medicine
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 43
    • 0029888311 scopus 로고    scopus 로고
    • Role of oxidants in ischemic brain damage
    • Chan PH. Role of oxidants in ischemic brain damage. Stroke 27: 1124-1129 (1996).
    • (1996) Stroke , vol.27 , pp. 1124-1129
    • Chan, P.H.1
  • 44
    • 0032531916 scopus 로고    scopus 로고
    • Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion
    • Chan PH, Kawase M, Murakami K, Chen SF, Li Y, Calagui B, et al. Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J Neurosci 18: 8292-8299 (1998).
    • (1998) J Neurosci , vol.18 , pp. 8292-8299
    • Chan, P.H.1    Kawase, M.2    Murakami, K.3    Chen, S.F.4    Li, Y.5    Calagui, B.6
  • 45
    • 0031661220 scopus 로고    scopus 로고
    • Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia
    • Fullerton HJ, Ditelberg JS, Chen SF, Sarco DP, Chan PH, Epstein CJ et al. Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Ann Neurol 44: 357-364 (1998).
    • (1998) Ann Neurol , vol.44 , pp. 357-364
    • Fullerton, H.J.1    Ditelberg, J.S.2    Chen, S.F.3    Sarco, D.P.4    Chan, P.H.5    Epstein, C.J.6
  • 46
    • 2342429376 scopus 로고    scopus 로고
    • Alzheimer disease: Evidence for a central pathogenic role of iron-mediated reactive oxygen species
    • Casadesus G, Smith MA, Zhu X, Aliev G, Cash AD, Honda K, et al. Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. J Alzheimers Dis 6: 165-169 (2004).
    • (2004) J Alzheimers Dis , vol.6 , pp. 165-169
    • Casadesus, G.1    Smith, M.A.2    Zhu, X.3    Aliev, G.4    Cash, A.D.5    Honda, K.6
  • 47
    • 11844272073 scopus 로고    scopus 로고
    • Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice
    • Schuessel K, Schafer S, Bayer TA, Czech C, Pradier L, Muller-Spahn F, et al. Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice. Neurobiol Dis 18: 89-99 (2005).
    • (2005) Neurobiol Dis , vol.18 , pp. 89-99
    • Schuessel, K.1    Schafer, S.2    Bayer, T.A.3    Czech, C.4    Pradier, L.5    Muller-Spahn, F.6
  • 48
    • 15744398884 scopus 로고    scopus 로고
    • Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases
    • Choi J, Rees HD, Weintraub ST, Levey AI, Chin LS and Li L. Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases. J Biol Chem 280: 11648-11655 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 11648-11655
    • Choi, J.1    Rees, H.D.2    Weintraub, S.T.3    Levey, A.I.4    Chin, L.S.5    Li, L.6
  • 50
    • 0027216632 scopus 로고
    • Changes of mitochondrial DNA and heat shock protein gene expressions in gerbil hippocampus after transient forebrain ischemia
    • Abe K, Kawagoe J, Aoki M and Kogure K. Changes of mitochondrial DNA and heat shock protein gene expressions in gerbil hippocampus after transient forebrain ischemia. J Cereb Blood Flow Metab 13: 773-780 (1993).
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 773-780
    • Abe, K.1    Kawagoe, J.2    Aoki, M.3    Kogure, K.4
  • 51
    • 0031974368 scopus 로고    scopus 로고
    • Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
    • Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, et al. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18: 205-213 (1998).
    • (1998) J Neurosci , vol.18 , pp. 205-213
    • Murakami, K.1    Kondo, T.2    Kawase, M.3    Li, Y.4    Sato, S.5    Chen, S.F.6
  • 54
    • 2542632121 scopus 로고    scopus 로고
    • Oxidative stress is associated with XIAP and Smac/DIABLO signaling pathways in mouse brains after transient focal cerebral ischemia
    • Saito A, Hayashi T, Okuno S, Nishi T and Chan PH. Oxidative stress is associated with XIAP and Smac/DIABLO signaling pathways in mouse brains after transient focal cerebral ischemia. Stroke 35: 1443-1448 (2004).
    • (2004) Stroke , vol.35 , pp. 1443-1448
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Nishi, T.4    Chan, P.H.5
  • 55
    • 0033495895 scopus 로고    scopus 로고
    • Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion
    • Matsumoto S, Friberg H, Ferrand-Drake M and Wieloch T. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 19: 736-741 (1999).
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 736-741
    • Matsumoto, S.1    Friberg, H.2    Ferrand-Drake, M.3    Wieloch, T.4
  • 56
    • 0035045290 scopus 로고    scopus 로고
    • Intracellular Bax translocation after transient cerebral ischemia: Implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death
    • Cao G, Minami M, Pei W, Yan C, Chen D, O'Horo C, et al. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. J Cereb Blood Flow Metab 21: 321-333 (2001).
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 321-333
    • Cao, G.1    Minami, M.2    Pei, W.3    Yan, C.4    Chen, D.5    O'Horo, C.6
  • 57
    • 0036548511 scopus 로고    scopus 로고
    • The permeability transition pore signals apoptosis by directing Bax translocation and multimerization
    • De Giorgi F, Lartigue L, Bauer MK, Schubert A, Grimm S, Hanson GT, et al. The permeability transition pore signals apoptosis by directing Bax translocation and multimerization. FASEB J 16: 607-609 (2002).
    • (2002) FASEB J , vol.16 , pp. 607-609
    • De Giorgi, F.1    Lartigue, L.2    Bauer, M.K.3    Schubert, A.4    Grimm, S.5    Hanson, G.T.6
  • 58
    • 4544255383 scopus 로고    scopus 로고
    • The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia
    • Okuno S, Saito A, Hayashi T and Chan PH. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J Neurosci 24 : 7879-7887 (2004).
    • (2004) J Neurosci , vol.24 , pp. 7879-7887
    • Okuno, S.1    Saito, A.2    Hayashi, T.3    Chan, P.H.4
  • 59
    • 0034655765 scopus 로고    scopus 로고
    • The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice
    • Fujimura M, Morita-Fujimura Y, Noshita N, Sugawara T, Kawase M and Chan PH. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J Neurosci 20: 2817-2824 (2000).
    • (2000) J Neurosci , vol.20 , pp. 2817-2824
    • Fujimura, M.1    Morita-Fujimura, Y.2    Noshita, N.3    Sugawara, T.4    Kawase, M.5    Chan, P.H.6
  • 60
    • 4243220914 scopus 로고    scopus 로고
    • Neuronal RNA oxidation and mitochondrial proliferation denote profound metabolic abnormalities in Alzheimer disease
    • Hirai K, Smith MA, Wade R and Perry G. Neuronal RNA oxidation and mitochondrial proliferation denote profound metabolic abnormalities in Alzheimer disease. Neurobiol Aging 19(Suppl 4S): S4-5 (1998).
    • (1998) Neurobiol Aging , vol.19 , Issue.SUPPL. 4S
    • Hirai, K.1    Smith, M.A.2    Wade, R.3    Perry, G.4
  • 61
    • 18244390483 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
    • Bubber P, Haroutunian V, Fisch G, Blass JP and Gibson GE. Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol 57: 695-703 (2005).
    • (2005) Ann Neurol , vol.57 , pp. 695-703
    • Bubber, P.1    Haroutunian, V.2    Fisch, G.3    Blass, J.P.4    Gibson, G.E.5
  • 63
    • 0036968953 scopus 로고    scopus 로고
    • Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain
    • Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW and Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis 11: 341-354 (2002).
    • (2002) Neurobiol Dis , vol.11 , pp. 341-354
    • Rohn, T.T.1    Rissman, R.A.2    Davis, M.C.3    Kim, Y.E.4    Cotman, C.W.5    Head, E.6
  • 64
    • 5044220307 scopus 로고    scopus 로고
    • Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease
    • Tacconi S, Perri R, Balestrieri E, Grelli S, Bernardini S, Annichiarico R, et al. Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease. Exp Neurol 190: 254-262 (2004).
    • (2004) Exp Neurol , vol.190 , pp. 254-262
    • Tacconi, S.1    Perri, R.2    Balestrieri, E.3    Grelli, S.4    Bernardini, S.5    Annichiarico, R.6
  • 65
    • 0021968895 scopus 로고
    • Changes in brain energy metabolism and protein synthesis following transient bilateral ischemia in the gerbil
    • Nowak TS Jr, Fried RL, Lust WD and Passonneau JV. Changes in brain energy metabolism and protein synthesis following transient bilateral ischemia in the gerbil. J Neurochem 44: 487-494 (1985).
    • (1985) J Neurochem , vol.44 , pp. 487-494
    • Nowak Jr., T.S.1    Fried, R.L.2    Lust, W.D.3    Passonneau, J.V.4
  • 66
    • 2942755868 scopus 로고    scopus 로고
    • Signaling the unfolded protein response from the endoplasmic reticulum
    • Zhang K and Kaufman RJ. Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 279: 25935-25938 (2004).
    • (2004) J Biol Chem , vol.279 , pp. 25935-25938
    • Zhang, K.1    Kaufman, R.J.2
  • 67
    • 0032079873 scopus 로고    scopus 로고
    • Regulation of translation initiation factors by signal transduction
    • Kleijn M, Scheper GC, Voorma HO and Thomas AA. Regulation of translation initiation factors by signal transduction. Eur J Biochem 253: 531-544 (1998).
    • (1998) Eur J Biochem , vol.253 , pp. 531-544
    • Kleijn, M.1    Scheper, G.C.2    Voorma, H.O.3    Thomas, A.A.4
  • 68
    • 0023878562 scopus 로고
    • The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2
    • Rowlands AG, Panniers R and Henshaw EC. The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2. J Biol Chem 263: 5526-5533 (1988).
    • (1988) J Biol Chem , vol.263 , pp. 5526-5533
    • Rowlands, A.G.1    Panniers, R.2    Henshaw, E.C.3
  • 69
    • 0030730131 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 2B (eIF2B)
    • Webb BL and Proud CG. Eukaryotic initiation factor 2B (eIF2B). Int J Biochem Cell Biol 29: 1127-1131 (1997).
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 1127-1131
    • Webb, B.L.1    Proud, C.G.2
  • 70
    • 0034889904 scopus 로고    scopus 로고
    • Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice
    • Althausen S, Mengesdorf T, Mies G, Olah L, Nairn AC, Proud CG, et al. Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice. J Neurochem 78: 779-787 (2001).
    • (2001) J Neurochem , vol.78 , pp. 779-787
    • Althausen, S.1    Mengesdorf, T.2    Mies, G.3    Olah, L.4    Nairn, A.C.5    Proud, C.G.6
  • 71
    • 0035901755 scopus 로고    scopus 로고
    • Ischemia-induced inhibition of the initiation factor 2α phosphatase activity in the rat brain
    • de la Vega CM, Burda J and Salinas M. Ischemia-induced inhibition of the initiation factor 2α phosphatase activity in the rat brain. Neuroreport 12: 1021-1025 (2001).
    • (2001) Neuroreport , vol.12 , pp. 1021-1025
    • De La Vega, C.M.1    Burda, J.2    Salinas, M.3
  • 72
    • 0034996080 scopus 로고    scopus 로고
    • Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK
    • Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, et al. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK. J Neurochem 77: 1418-1421 (2001).
    • (2001) J Neurochem , vol.77 , pp. 1418-1421
    • Kumar, R.1    Azam, S.2    Sullivan, J.M.3    Owen, C.4    Cavener, D.R.5    Zhang, P.6
  • 73
    • 0041568574 scopus 로고    scopus 로고
    • Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death
    • Hayashi T, Saito A, Okuno S, Ferrand-Drake M, Chan PH. Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death. J Cereb Blood Flow Metab 23: 949-961 (2003).
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 949-961
    • Hayashi, T.1    Saito, A.2    Okuno, S.3    Ferrand-Drake, M.4    Chan, P.H.5
  • 74
    • 4444232905 scopus 로고    scopus 로고
    • The unfolded protein response - A stress signaling pathway of the endoplasmic reticulum
    • Shen X, Zhang K and Kaufman RJ. The unfolded protein response - a stress signaling pathway of the endoplasmic reticulum. J Chem Neuroanat 28: 79-92 (2004).
    • (2004) J Chem Neuroanat , vol.28 , pp. 79-92
    • Shen, X.1    Zhang, K.2    Kaufman, R.J.3
  • 75
    • 1542300773 scopus 로고    scopus 로고
    • Oxidative injury to the endoplasmic reticulum in mouse brains after transient focal ischemia
    • Hayashi T, Saito A, Okuno S, Ferrand-Drake M, Dodd RL, Chan PH. Oxidative injury to the endoplasmic reticulum in mouse brains after transient focal ischemia. Neurobiol Dis 15: 229-39 (2004).
    • (2004) Neurobiol Dis , vol.15 , pp. 229-239
    • Hayashi, T.1    Saito, A.2    Okuno, S.3    Ferrand-Drake, M.4    Dodd, R.L.5    Chan, P.H.6
  • 76
    • 0032979420 scopus 로고    scopus 로고
    • Disturbances of the functioning of endoplasmic reticulum: A key mechanism underlying neuronal cell injury?
    • Paschen W and Doutheil J. Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury? J Cereb Blood Flow Metab 19: 1-18 (1999).
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1-18
    • Paschen, W.1    Doutheil, J.2
  • 79
    • 20444390622 scopus 로고    scopus 로고
    • The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers
    • Li F, Hayashi T, Jin G, Deguchi K, Nagotani S, Nagano I, et al. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Brain Res 1048: 59-68 (2005).
    • (2005) Brain Res , vol.1048 , pp. 59-68
    • Li, F.1    Hayashi, T.2    Jin, G.3    Deguchi, K.4    Nagotani, S.5    Nagano, I.6
  • 80
    • 0037428823 scopus 로고    scopus 로고
    • Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat
    • Mouw G, Zechel JL, Gamboa J, Lust WD, Selman WR, Ratcheson RA. Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat. Neuroreport 14: 183-186 (2003).
    • (2003) Neuroreport , vol.14 , pp. 183-186
    • Mouw, G.1    Zechel, J.L.2    Gamboa, J.3    Lust, W.D.4    Selman, W.R.5    Ratcheson, R.A.6
  • 81
    • 0037426614 scopus 로고    scopus 로고
    • Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice
    • Shibata M, Hattori H, Sasaki T, Gotoh J, Hamada J, Fukuuchi Y. Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice. Neuroscience 118: 491-499 (2003).
    • (2003) Neuroscience , vol.118 , pp. 491-499
    • Shibata, M.1    Hattori, H.2    Sasaki, T.3    Gotoh, J.4    Hamada, J.5    Fukuuchi, Y.6
  • 82
    • 0033016172 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
    • Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, et al. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med 5: 101-106 (1999).
    • (1999) Nat Med , vol.5 , pp. 101-106
    • Guo, Q.1    Fu, W.2    Sopher, B.L.3    Miller, M.W.4    Ware, C.B.5    Martin, G.M.6
  • 83
    • 0035900779 scopus 로고    scopus 로고
    • Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations
    • Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, et al. Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations. J Biol Chem 276: 43446-54 (2001).
    • (2001) J Biol Chem , vol.276 , pp. 43446-43454
    • Katayama, T.1    Imaizumi, K.2    Honda, A.3    Yoneda, T.4    Kudo, T.5    Takeda, M.6
  • 85
    • 0033258544 scopus 로고    scopus 로고
    • Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
    • Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, et al. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Bio 1: 479-485 (1999).
    • (1999) Nat Cell Bio , vol.1 , pp. 479-485
    • Katayama, T.1    Imaizumi, K.2    Sato, N.3    Miyoshi, K.4    Kudo, T.5    Hitomi, J.6
  • 87
    • 0036897873 scopus 로고    scopus 로고
    • Caspase-independent cell deaths
    • Locksin RA and Zakeri Z. Caspase-independent cell deaths. Curr Opin Cell Biol 14: 727-733 (2002).
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 727-733
    • Locksin, R.A.1    Zakeri, Z.2
  • 88
    • 0034304390 scopus 로고    scopus 로고
    • The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: A review
    • Nixon RA, Cataldo AM and Mathews PM. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochem Res 25: 1161-1172 (2000).
    • (2000) Neurochem Res , vol.25 , pp. 1161-1172
    • Nixon, R.A.1    Cataldo, A.M.2    Mathews, P.M.3
  • 89
    • 17744402995 scopus 로고    scopus 로고
    • Evaluation of lipid peroxidation, cathepsin L and acid phosphatase activities in experimental brain ischemia-reperfusion
    • Islekel H, Islekel S, Guner G and Ozdamar N. Evaluation of lipid peroxidation, cathepsin L and acid phosphatase activities in experimental brain ischemia-reperfusion. Brain Res 843: 18-24 (1999).
    • (1999) Brain Res , vol.843 , pp. 18-24
    • Islekel, H.1    Islekel, S.2    Guner, G.3    Ozdamar, N.4
  • 90
    • 0030836345 scopus 로고    scopus 로고
    • Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased beta-amyloidogenesis
    • Cataldo AM, Barnett JL, Pieroni C and Nixon RA. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. J Neurosci 17: 6142-6151 (1997).
    • (1997) J Neurosci , vol.17 , pp. 6142-6151
    • Cataldo, A.M.1    Barnett, J.L.2    Pieroni, C.3    Nixon, R.A.4
  • 91
    • 0032526652 scopus 로고    scopus 로고
    • Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis
    • Yang AJ, Chandswangbhuvana D, Margol L and Glabe CG. Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis. J Neurosci Res 52: 691-698 (1998).
    • (1998) J Neurosci Res , vol.52 , pp. 691-698
    • Yang, A.J.1    Chandswangbhuvana, D.2    Margol, L.3    Glabe, C.G.4
  • 92
    • 20444430784 scopus 로고    scopus 로고
    • Is Alzheimer's disease preceded by neurodegeneration or cerebral hypoperfusion?
    • de la Torre JC. Is Alzheimer's disease preceded by neurodegeneration or cerebral hypoperfusion? Ann Neurol 57: 783-784 (2005).
    • (2005) Ann Neurol , vol.57 , pp. 783-784
    • De La Torre, J.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.