Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion

Experimental Brain Research

Volumn 120, Issue 4, 1998, Pages 503-509

  Kristián, Tibor ^a,b   Gidö, Gunilla ^a   Kuroda, Satoshi ^a   Schütz, Andrejs ^a   Siesjö, Bo K ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b QUEEN S MEDICAL CENTER   (United States)

Author keywords

Extracellular calcium concentration; Middle cerebral artery occlusion; Rat; Reperfusion; Total tissue calcium content

Indexed keywords

CALCIUM ION; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BRAIN EDEMA; CALCIUM METABOLISM; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; EXTRACELLULAR CALCIUM; INTRACELLULAR FLUID; ION SELECTIVE ELECTRODE; MALE; MICROELECTRODE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; WATER CONTENT;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; BRAIN CHEMISTRY; CALCIUM; CEREBRAL INFARCTION; EXTRACELLULAR SPACE; ISCHEMIC ATTACK, TRANSIENT; MALE; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 0031840150     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050424     Document Type: Article

References (57)

1. Back T, Kohono K, Hossmann K-A (1994) Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: effect on blood flow tissue oxygenation, and electroencephalogram. J Cereb Blood Flow Metab 14:12-19
2. Bederson J, Pitts L, Tsuji M, Nishimura M, Davis R, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurological examination (abstract). Stroke 17:472
3. Bernardi P, Petronilli V (1996) The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal. J Bioenerg Biomemor 28:131-137
4. Bradbury M, Kleeman C, Bagdoyan H, Berberian A (1968) The calcium and magnesion content of skeletal muscle, brain, and cerebrospinal fluid as determined by atomic absorption flame photometry. J Lab Clin Med 71:884-892
5. Carafoli E (1987) Intracellular calcium homeostasis. Annu Rev Biochem 56:395-433
6. 2+ dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem J 255:357-360
7. Deshpande JK, Siesjö BK, Wieloch T (1987) Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischemia. J Cereb Blood Flow Metab 7:89-95
8. Dienel GA (1984) Regional accumulation of calcium in postischemic rat brain. J Neurochem 43:913-925
9. Duchen M, Mcguinness O, Brown L, Crompton M (1993) On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury. Cardiovasc Res 27:1790-1794
10. Dux E, Mies G, Hossmann K-A, Siklos L (1987) Calcium in the mitochondria following brief ischemia of gerbil brain. Neurosci Lett 78:295-300
11. Ekholm A, Siesjö BK (1992) A technique for brain temperature control during ischemia suitable for measurements with ion sensitive microelectrodes. J Neurol Anesth 4:272-277
12. Ekholm A, Kristián T, Siesjö B (1995) Influence of hyperglycemia and of hypercapnia on cellular calcium during reversible brain ischemia. Exp Brain Res 104:462-466
13. Erecinska M, Silver I (1994) Ions and energy in mammalian brain. Prog Neurobiol 43:37-71
14. Folbergrová J, Zhao Q, Katsura K, Siesjö B (1995) N-tert-butyl-a-phenylnitrone improves recovery of brain energy state in the rats following transient focal ischemia. Proc Natl Acad Sci USA 92:5057-5061
15. Gidö G, Kristián T, Siesjö BK (1997) Extracellular potassium in a neocortical core area after transient focal ischemia. Stroke 28:206-210
16. Gill R, Andiné P, Hillered L, Persson L, Hagberg H (1992) The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischemia in the rat. J Cereb Blood Flow Metab 12:371-379
17. Hansen AJ (1985) Effects of anoxia on ion distribution in the brain. Physiol Rev 65:101-148
18. Hansen A, Zeuthen T (1981) Extracellular ion concentration during spreading depression and ischemia in the rat brain cortex. Acta Physiol Scand 113:437-445
19. Harris RJ, Symon L, Branston NM, Bayhan M (1981) Changes in extracellular calcium activity in cerebral ischaemia. J Cereb Blood Flow Metab 1:203-209
20. Hossmann K-A (1994) Glutamate-mediated injury in focal cerebral ischemia: the excitotoxin hypothesis revised. Brain Pathol 4:23-36
21. Iijima T, Mies G, Hossmann K-A (1992) Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J Cereb Blood Flow Metab 12:727-733
22. Kato H, Kogure K, Sakamoto N, Watanabe T (1987) Greater disturbance of water and ion homeostasis in the periphery of experimental focal cerebral ischemia. Exp Neurol 96:118-126
23. Katzman R, Pappius H (1973) Brain electrolytes and fluid metabolism. Williams and Wilkins, Baltimore
24. Kirino T, Robinson H, Miwa A, Tamura A, Kawai N (1992) Disturbance of membrane function preceding ischemic delayed neuronal death in the gerbil hippocampus. J Cereb Blood Flow Metab 12:408-417
25. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischemic brain edema, 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8:1-8
26. Kristián T, Siesjö BK (1996a) Changes in ionic fluxes during cerebral ischemia. Int Rev Neurobiol 27-45
27. Kristián T, Siesjö B (1996b) Calcium-related damage in ischemia. Life Sci 59:357-367
28. Kristián T, Gidö G, Siesjö BK (1993) Brain calcium metabolism in hypoglycemic coma. J Cereb Blood Flow Metab 13:955-961
29. Kristián T, Katsura K, Gidö G, Siesjö BK (1994) The influence of pH on cellular calcium influx during ischemia. Brain Res 641:295-302
30. Kristián T, Gidö G, Siesjö BK (1995) Temporal profile of extracellular ion concentrations following transient middle cerebral artery occlusion in the rat. Soc Neurosci Abstr 216
31. Kuroda S, Katsura K, Tsuchidate R, Siesjö B (1995) Secondary bioenergetic failure after transient focal ischemia is due to mitochondrial injury. Acta Physiol Scand 156:149-150
32. Kuroda S, Katsura K, Hillered L, Bates T, Siesjö B (1996) Delayed treatment with α-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiol Dis 3:149-157
33. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
34. Martins E, Inamura K, Themner K, Malmqvist KG, Siesjö BK (1988) Accumulation of calcium and loss of potassium in the hippocampus following transient cerebral ischemia: a proton microprobe study. J Cereb Blood Flow Metab 8:531-538
35. Memezawa H, Smith M-L, Siesjö BK (1992) Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 23:552-559
36. 2+ homeostasis. Prog Neurobiol 37:255-285
37. 45Ca into brain and cerebrospinal fluid from plasma during chronic hypocalcemia in rats. Brain Res 454:315-320
38. Nedergaard M, Hansen AJ (1993) Characterization of cortical depolarizations evoked in focal cerebral ischemia. J Cereb Blood Flow Metab 13:568-574
39. Nicholson C, Bruggencate GT, Steinberg R, Stockle H (1977) Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette. Proc Natl Acad Sci USA 74:1287-1290
40. Pontén U, Ratcheson RA, Salford LG, Siesjö BK (1973) Optimal freezing conditions for cerebral metabolites in rats. J Neurochem 21:1127-1138
41. Pulsinelli W (1992) Pathophysiology of acute ischemic stroke. Lancet 339:533-536
42. Pulsinelli W, Jacewicz M, Buchan A (1992) Antagonists of excitatory amino acid neurotransmitters: a comparison of their effects on global versus focal ischemia. (Drug research related to neuroactive amino acids). Munksgaard, Copenhagen
43. Rappaport ZH, Young W, Flamm ES (1987) Regional brain calcium changes in the rat middle cerebral artery occlusion model of ischemia. Stroke 18:760-764
44. Shirotani T, Shima K, Iwata M, Kita H, Chigasaki H (1994) Calcium accumulation following middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. J Cereb Blood Flow Metab 14:831-836
45. Siemkowicz E, Hansen AJ (1981) Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo-and hyperglycemic rats. Stroke 12:236-240
46. Siesjö BK (1992a) Pathophysiology and treatment of focal cerebral ischemia. I. Pathophysiology. J Neurosurg 77:169-184
47. Siesjö BK (1992b) Pathophysiology and treatment of focal cerebral ischemia. II. Mechanisms of damage and treatment. J Neurosurg 77:337-354
48. Siesjö B, Siesjö P (1996) Mechanisms of secondary brain injury. Eur J Anesth 13:247-268
49. Siesjö BK, Ekholm A, Katsura K, Memezawa H, Ohta S, Smith M-L (1990) The type of ischemia determines the pathophysiology of brain lesions and the therapeutic response to calcium channel blockade. In: Krieglstein J, Oberpichler H (eds) Pharmacology of cerebral ischemia. Stuttgart, pp 79-88
50. 2+] in hypoxia and ischemia in rat brain in vivo. J Gen Physiol 95:837-866
51. + in the hippocampus during recovery from short-term transient ischemia. J Cereb Blood Flow Metab 12:759-772
52. Simon RP, Griffiths T, Evans MC, Swan JH, Meldrum BS (1984) Calcium overload in selectively vulnerable neurons of the hippocampus during and after ischemia: an electron microscopy study in the rat. J Cereb Blood Flow Metab 4:350-361
53. Uchino H, Elmér E, Uchino K, Lindvall O, Siesjö B (1995) Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischemia in the rat. Acta Physiol Scand 155:469-471
54. Young W, DeCrescito V, Flamm ES, Hadani M, Rappaport H, Cornu P (1986) Tissue Na, K, and Ca changes in regional cerebral ischemia: their measurement and interpretation. Cent Nerv Syst Trauma 3:215-234
55. Zaidan E, Sims N (1994) The calcium content of mitochondria from brain subregions following short-term forebrain ischemia and recirculation in the rat. J Neurochem 63:1812-1819
56. Zhao Q, Memezawa H, Smith M-L, Siesjö BK (1994) Hyperthermia complicates middle cerebral artery occlusion induced by an intraluminal filament. Brain Res 649:353-259
57. Zoratti M, Szabó I (1995) The mitochondrial permeability transition. Biochim Biophys Acta 1241:139-176