Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5462-5467

  Cain, James P ^a   Mayorov, Alexander V ^a   Cai, Minying ^a   Wang, Hui ^a   Tan, Bahar ^a   Chandler, Kevin ^a   Lee, YeonSun ^a   Petrov, Ravil R ^a   Trivedi, Dev ^a   Hruby, Victor J ^a  

^a University of Arizona   (United States)

Author keywords

GPCRs; Melanocortins; Peptide mimetics

Indexed keywords

AMINO ACID; BICYCLO COMPOUND; FUNCTIONAL GROUP; G PROTEIN COUPLED RECEPTOR; HMC 001; HMC 002; HMC 009; HMC 010; HMC 013; HMC 014; HMC 021; HMC 025; MELANOCORTIN RECEPTOR; PEPTIDE DERIVATIVE; RECEPTOR SUBTYPE; SMALL MOLECULE PEPTIDE MIMETIC; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; CANCER; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENERGY BALANCE; HOMEOSTASIS; HUMAN; HUMAN CELL; INFLAMMATION; MOLECULAR MODEL; OBESITY; PAIN; PENIS ERECTION; PHARMACOPHORE; PIGMENTATION; RECEPTOR AFFINITY; STEREOCHEMISTRY; STEREOISOMERISM; STEROIDOGENESIS;

BINDING SITES; CELL LINE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PEPTIDES; RECEPTORS, MELANOCORTIN; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748324542     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.015     Document Type: Article

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