The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 17, 1999, Pages 2497-2502

  Cody, Wayne L ^a   Cai, Cuiman ^a   Doherty, Annette M ^a   Edmunds, Jeremy J ^a   He, John X ^a   Narasimhan, Lakshmi S ^a   Plummer, Janet S ^a   Rapundalo, Stephen T ^a   Rubin, J Ronald ^a   Van Huis, Chad A ^a   Yves, St Denis ^b   Winocour, Peter D ^b   Siddiqui, M Arshad ^b  

^a PFIZER INC   (United States)

^b Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; PIPERAZINEDIONE; SERINE; THROMBIN; THROMBIN INHIBITOR; TRYPSIN;

ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ANTITHROMBINS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MODELS, MOLECULAR; PIPERAZINES;

EID: 0033530133     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00418-7     Document Type: Article

References (11)

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