Biological and conformational study of β-substituted prolines in MT-II template: Steric effects leading to human MC5 receptor selectivity

Journal of Peptide Research

Volumn 63, Issue 2, 2004, Pages 116-131

  Cai, M ^a   Cai, C ^a,b   Mayorov, A V ^a   Xiong, C ^a   Cabello, C M ^a   Soloshonok, V A ^a,c   Swift, J R ^a   Trivedi, D ^a   Hruby, V J ^a  

^a University of Arizona   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

MSH; hMC5R; Melanocortin receptors; Melanotropin agonists; Melanotropin antagonists; MT II; Selective ligands; Steric constraints

Indexed keywords

HISTIDINE; INTERMEDIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 5 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; N ACETYLNORLEUCYLCYCLO(ASPARTYL 3 PHENYLPROLYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE)AMIDE; N ACETYLNORLEUCYLCYCLO(ASPARTYLHISTIDYL DEXTRO 3 PHENYLPROLYLARGINYLTRYPTOPHYLLYSINE)AMIDE; N ACETYLNORLEUCYLCYCLO(ASPARTYLHISTIDYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE)AMIDE; N ACETYLNORLEUCYLCYCLO[ASPARTYL 3 (4 BROMOPHENYL)PROLYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE]AMIDE; N ACETYLNORLEUCYLCYCLO[ASPARTYL 3 (4 CHLOROPHENYL)PROLYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE]AMIDE; N ACETYLNORLEUCYLCYCLO[ASPARTYL 3 (4 METHOXYPHENYL)PROLYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE]AMIDE; N ACETYLNORLEUCYLCYCLO[ASPARTYL 3 (4 TRIFLUOROMETHYLPHENYL)PROLYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE]AMIDE; PEPTIDE; PHENYLALANINE; PROLINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR INTRINSIC ACTIVITY; SIMULATION;

ADENYLATE CYCLASE; ALPHA-MSH; BINDING, COMPETITIVE; CELL LINE; HUMANS; MELANOCYTE-STIMULATING HORMONES; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDES; PROLINE; PROTEIN CONFORMATION; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1542725948     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2003.00105.x     Document Type: Article

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