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Volumn 118, Issue 3, 2003, Pages 755-762

Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors

Author keywords

MSH; MT II; Rats; Sex behavior; SHU 9119; Spinal cord

Indexed keywords

ACETYLNORLEUCINE CYCLO(ASPARTYLHISTIDYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLLYSINE)AMIDE; AMIDE; BRAIN RECEPTOR; MELANOCORTIN; MELANOCORTIN RECEPTOR; MT II; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; UNCLASSIFIED DRUG;

EID: 0242418191     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00866-7     Document Type: Article
Times cited : (64)

References (42)
  • 1
    • 0024310869 scopus 로고
    • Potent and prolonged acting cyclic lactam analogues of α-melanotropin: Design based on molecular dynamics
    • Al-Obeidi F., de La Castrucci A.M., Hadley M.E., Hruby V.J. Potent and prolonged acting cyclic lactam analogues of α-melanotropin design based on molecular dynamics . J Med Chem. 32:1989;2555-2561.
    • (1989) J Med Chem , vol.32 , pp. 2555-2561
    • Al-Obeidi, F.1    De La Castrucci, A.M.2    Hadley, M.E.3    Hruby, V.J.4
  • 2
    • 0034849563 scopus 로고    scopus 로고
    • Pharmacology of penile erection
    • Andersson K.E. Pharmacology of penile erection. Pharmacol Rev. 53:2001;417-450.
    • (2001) Pharmacol Rev , vol.53 , pp. 417-450
    • Andersson, K.E.1
  • 3
    • 0023712068 scopus 로고
    • Yawning and penile erection: Central dopamine-oxytocin-adrenocorticotropin connection
    • Argiolas A., Melis M.R., Gessa G.L. Yawning and penile erection central dopamine-oxytocin-adrenocorticotropin connection . Ann N Y Acad Sci. 525:1988;330-337.
    • (1988) Ann N Y Acad Sci , vol.525 , pp. 330-337
    • Argiolas, A.1    Melis, M.R.2    Gessa, G.L.3
  • 4
    • 0034014197 scopus 로고    scopus 로고
    • ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: Site of action in the brain and role of melanocortin receptors
    • Argiolas A., Melis M.R., Murgia S., Schioth H.B. ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats site of action in the brain and role of melanocortin receptors . Brain Res Bull. 51:2000;425-431.
    • (2000) Brain Res Bull , vol.51 , pp. 425-431
    • Argiolas, A.1    Melis, M.R.2    Murgia, S.3    Schioth, H.B.4
  • 5
    • 0018568670 scopus 로고
    • Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats
    • Benassi-Benelli A., Ferrari F., Quarantotti B.P. Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats. Arch Int Pharmacodyn Ther. 242:1979;241-247.
    • (1979) Arch Int Pharmacodyn Ther , vol.242 , pp. 241-247
    • Benassi-Benelli, A.1    Ferrari, F.2    Quarantotti, B.P.3
  • 6
    • 0033023938 scopus 로고    scopus 로고
    • Intracavernous pressure during erection in rats: An integrative approach based on telemetric recording
    • Bernabe J., Rampin O., Sachs B.D., Giuliano F. Intracavernous pressure during erection in rats an integrative approach based on telemetric recording . Am J Physiol. 276:1999;R441-R449.
    • (1999) Am J Physiol , vol.276
    • Bernabe, J.1    Rampin, O.2    Sachs, B.D.3    Giuliano, F.4
  • 7
    • 0019407158 scopus 로고
    • Behavioral effects of ACTH-MSH peptides
    • Bertolini A., Gessa G.L. Behavioral effects of ACTH-MSH peptides. J Endocrinol Invest. 4:1981;241-251.
    • (1981) J Endocrinol Invest , vol.4 , pp. 241-251
    • Bertolini, A.1    Gessa, G.L.2
  • 8
    • 0018129989 scopus 로고
    • Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
    • Buijs R.M., Swaab D.F., Dogterom J., van Leeuwen F.W. Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Cell Tissue Res. 186:1978;423-433.
    • (1978) Cell Tissue Res , vol.186 , pp. 423-433
    • Buijs, R.M.1    Swaab, D.F.2    Dogterom, J.3    Van Leeuwen, F.W.4
  • 10
    • 0027257671 scopus 로고
    • Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior
    • Dornan W.A., Vink K.L., Malen P., Short K., Struthers W., Barrett C. Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior. Physiol Behav. 54:1993;249-258.
    • (1993) Physiol Behav , vol.54 , pp. 249-258
    • Dornan, W.A.1    Vink, K.L.2    Malen, P.3    Short, K.4    Struthers, W.5    Barrett, C.6
  • 11
    • 0029980737 scopus 로고    scopus 로고
    • Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study
    • Dorr R.T., Lines R., Levine N., Brooks C., Xiang L., Hruby V.J., Hadley M.E. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 58:1996;1777-1784.
    • (1996) Life Sci , vol.58 , pp. 1777-1784
    • Dorr, R.T.1    Lines, R.2    Levine, N.3    Brooks, C.4    Xiang, L.5    Hruby, V.J.6    Hadley, M.E.7
  • 12
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W., Boston B.A., Kesterson R.A., Hruby V.J., Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385:1997;165-168.
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 15
    • 0034130955 scopus 로고    scopus 로고
    • Central neural regulation of penile erection
    • Giuliano F., Rampin O. Central neural regulation of penile erection. Neurosci Biobehav Rev. 24:2000;517-533.
    • (2000) Neurosci Biobehav Rev , vol.24 , pp. 517-533
    • Giuliano, F.1    Rampin, O.2
  • 18
    • 0033998015 scopus 로고    scopus 로고
    • Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions
    • Haskell-Luevano C., Lim S., Yuan W., Cone R.D., Hruby V.J. Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions. Peptides. 21:2000;49-57.
    • (2000) Peptides , vol.21 , pp. 49-57
    • Haskell-Luevano, C.1    Lim, S.2    Yuan, W.3    Cone, R.D.4    Hruby, V.J.5
  • 19
    • 0018360118 scopus 로고
    • Identification and distribution of the spinal and hypophyseal projection neurons in the paraventricular nucleus of the rat: A light and electron microscopic study with the horseradish peroxidase method
    • Hosoya Y., Matsushita M. Identification and distribution of the spinal and hypophyseal projection neurons in the paraventricular nucleus of the rat a light and electron microscopic study with the horseradish peroxidase method . Exp Brain Res. 35:1979;315-331.
    • (1979) Exp Brain Res , vol.35 , pp. 315-331
    • Hosoya, Y.1    Matsushita, M.2
  • 20
    • 0029154516 scopus 로고
    • Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors
    • Hruby V.J., Lu D., Sharma S.D., Castrucci A.L., Kesterson R.A., al-Obeidi F.A., Hadley M.E., Cone R.D. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J Med Chem. 38:1995;3454-3461.
    • (1995) J Med Chem , vol.38 , pp. 3454-3461
    • Hruby, V.J.1    Lu, D.2    Sharma, S.D.3    Castrucci, A.L.4    Kesterson, R.A.5    Al-Obeidi, F.A.6    Hadley, M.E.7    Cone, R.D.8
  • 21
    • 0023775836 scopus 로고
    • The effects of simultaneous or separate infusions of some pro-opiomelanocortin-derived peptides (beta-endorphin, melanocyte stimulating hormone, and corticotrophin-like intermediate polypeptide) and their acetylated derivatives upon sexual and ingestive behaviour of male rats
    • Hughes A.M., Everitt B.J., Herbert J. The effects of simultaneous or separate infusions of some pro-opiomelanocortin-derived peptides (beta-endorphin, melanocyte stimulating hormone, and corticotrophin-like intermediate polypeptide) and their acetylated derivatives upon sexual and ingestive behaviour of male rats. Neuroscience. 27:1988;689-698.
    • (1988) Neuroscience , vol.27 , pp. 689-698
    • Hughes, A.M.1    Everitt, B.J.2    Herbert, J.3
  • 22
    • 0033540646 scopus 로고    scopus 로고
    • Sexual dysfunction in the United States: Prevalence and predictors
    • Laumann O., Paik A., Rosen R.C. Sexual dysfunction in the United States prevalence and predictors . JAMA. 281:1999;537-544.
    • (1999) JAMA , vol.281 , pp. 537-544
    • Laumann, O.1    Paik, A.2    Rosen, R.C.3
  • 23
    • 0023011642 scopus 로고
    • Intracerebroventricular injections in mice
    • Laursen S.E., Belknap J.K. Intracerebroventricular injections in mice. J Pharmacol Methods. 16:1986;355-357.
    • (1986) J Pharmacol Methods , vol.16 , pp. 355-357
    • Laursen, S.E.1    Belknap, J.K.2
  • 24
    • 0034660235 scopus 로고    scopus 로고
    • Erectile dysfunction
    • Lue T.F. Erectile dysfunction. N Engl J Med. 342:2000;1802-1813.
    • (2000) N Engl J Med , vol.342 , pp. 1802-1813
    • Lue, T.F.1
  • 26
    • 0033429342 scopus 로고    scopus 로고
    • Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogs
    • Marsh D.J., Miura G.I., Yagaloff K.A., Schwartz M.W., Barsh G.S., Palmiter R.D. Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogs. Brain Res. 848:1999;66-77.
    • (1999) Brain Res , vol.848 , pp. 66-77
    • Marsh, D.J.1    Miura, G.I.2    Yagaloff, K.A.3    Schwartz, M.W.4    Barsh, G.S.5    Palmiter, R.D.6
  • 27
    • 0031728655 scopus 로고    scopus 로고
    • The inter-relationship between gonadal steroids and POMC peptides, beta-endorphin and alpha-MSH, in the control of sexual behavior in the female rat
    • Medina F., Siddiqui A., Scimonelli T., Fenske C., Wilson C.A., Celis M.E. The inter-relationship between gonadal steroids and POMC peptides, beta-endorphin and alpha-MSH, in the control of sexual behavior in the female rat. Peptides. 19:1998;1309-1316.
    • (1998) Peptides , vol.19 , pp. 1309-1316
    • Medina, F.1    Siddiqui, A.2    Scimonelli, T.3    Fenske, C.4    Wilson, C.A.5    Celis, M.E.6
  • 28
    • 0029963477 scopus 로고    scopus 로고
    • Dopamine agonists increase nitric oxide production in the paraventricular nucleus of the hypothalamus: Correlation with penile erection and yawning
    • Melis M.R., Succu S., Argiolas A. Dopamine agonists increase nitric oxide production in the paraventricular nucleus of the hypothalamus correlation with penile erection and yawning . Eur J Neurosci. 8:1996;2056-2063.
    • (1996) Eur J Neurosci , vol.8 , pp. 2056-2063
    • Melis, M.R.1    Succu, S.2    Argiolas, A.3
  • 29
    • 0017041864 scopus 로고
    • Effect of ACTH 4-10 on copulatory behavior and on the response for socio-sexual motivation in the female rat
    • Meyerson B.J., Bohus B. Effect of ACTH 4-10 on copulatory behavior and on the response for socio-sexual motivation in the female rat. Pharmacol Biochem Behav. 5:1976;539-545.
    • (1976) Pharmacol Biochem Behav , vol.5 , pp. 539-545
    • Meyerson, B.J.1    Bohus, B.2
  • 30
    • 0036141886 scopus 로고    scopus 로고
    • Alpha-Melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat
    • Mizusawa H., Hedlund P., Andersson K.E. alpha-Melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat. J Urol. 167:2002;757-760.
    • (2002) J Urol , vol.167 , pp. 757-760
    • Mizusawa, H.1    Hedlund, P.2    Andersson, K.E.3
  • 32
    • 0028054953 scopus 로고
    • Kinetics of degradation of a cyclic lactam analog of alpha-melanotropin (MT-II) in aqueous solution
    • Ugwo S.O., Lan E.L., Sharma S., Hruby V.J., Blanchard J. Kinetics of degradation of a cyclic lactam analog of alpha-melanotropin (MT-II) in aqueous solution. Int J Pharm. 102:1994;193-199.
    • (1994) Int J Pharm , vol.102 , pp. 193-199
    • Ugwo, S.O.1    Lan, E.L.2    Sharma, S.3    Hruby, V.J.4    Blanchard, J.5
  • 33
    • 0031733790 scopus 로고    scopus 로고
    • Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands
    • van der Kraan M., Adan R.A., Entwistle M.L., Gispen W.H., Burbach J.P., Tatro J.B. Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands. Endocrinology. 139:1998;2348-2355.
    • (1998) Endocrinology , vol.139 , pp. 2348-2355
    • Van der Kraan, M.1    Adan, R.A.2    Entwistle, M.L.3    Gispen, W.H.4    Burbach, J.P.5    Tatro, J.B.6
  • 34
    • 0033534419 scopus 로고    scopus 로고
    • Expression of melanocortin receptors and pro-opiomelanocortin in the rat spinal cord in relation to neurotrophic effects of melanocortins
    • van der Kraan M., Tatro J.B., Entwistle M.L., Brakkee J.H., Burbach J.P., Adan R.A., Gispen W.H. Expression of melanocortin receptors and pro-opiomelanocortin in the rat spinal cord in relation to neurotrophic effects of melanocortins. Brain Res Mol Brain Res. 63:1999;276-286.
    • (1999) Brain Res Mol Brain Res , vol.63 , pp. 276-286
    • Van der Kraan, M.1    Tatro, J.B.2    Entwistle, M.L.3    Brakkee, J.H.4    Burbach, J.P.5    Adan, R.A.6    Gispen, W.H.7
  • 36
    • 0035675402 scopus 로고    scopus 로고
    • Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO
    • Vemulapalli R.K.S., Salisbury B., Parker E., Davis H. Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO. Br J Pharmacol. 134:2001;1705-1710.
    • (2001) Br J Pharmacol , vol.134 , pp. 1705-1710
    • Vemulapalli, R.K.S.1    Salisbury, B.2    Parker, E.3    Davis, H.4
  • 37
    • 0032409056 scopus 로고    scopus 로고
    • Differential influence of a selective melanocortin MC4 receptor antagonist (HS014) on melanocortin-induced behavioral effects in rats
    • Vergoni A.V., Bertolini A., Mutulis F., Wikberg J.E.S., Schioth H.B. Differential influence of a selective melanocortin MC4 receptor antagonist (HS014) on melanocortin-induced behavioral effects in rats. Eur J Pharmacol. 362:1998;95-101.
    • (1998) Eur J Pharmacol , vol.362 , pp. 95-101
    • Vergoni, A.V.1    Bertolini, A.2    Mutulis, F.3    Wikberg, J.E.S.4    Schioth, H.B.5
  • 39
    • 0032323804 scopus 로고    scopus 로고
    • Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind, placebo controlled crossover study
    • Wessells H., Fuciarelli K., Hansen J., Hadley M.E., Hruby V.J., Dorr R., Levine N. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction double-blind, placebo controlled crossover study . J Urol. 160:1998;389-393.
    • (1998) J Urol , vol.160 , pp. 389-393
    • Wessells, H.1    Fuciarelli, K.2    Hansen, J.3    Hadley, M.E.4    Hruby, V.J.5    Dorr, R.6    Levine, N.7
  • 40
    • 0033829159 scopus 로고    scopus 로고
    • Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction
    • Wessells H., Gralnek D., Dorr R., Hruby V.J., Hadley M.E., Levine N. Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology. 56:2000;641-646.
    • (2000) Urology , vol.56 , pp. 641-646
    • Wessells, H.1    Gralnek, D.2    Dorr, R.3    Hruby, V.J.4    Hadley, M.E.5    Levine, N.6
  • 42
    • 0017126435 scopus 로고
    • Analgesia mediated by a direct spinal action of narcotics
    • Yaksh T.L., Rudy T.A. Analgesia mediated by a direct spinal action of narcotics. Science. 192:1976;1357-1358.
    • (1976) Science , vol.192 , pp. 1357-1358
    • Yaksh, T.L.1    Rudy, T.A.2


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