A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells

Blood

Volumn 106, Issue 12, 2005, Pages 3867-3873

  Underhill, Greg H ^b   Zisoulis, Dimitrios G ^b   Kolli, K Pallav ^b   Ellies, Lesley G ^b   Marth, Jamey D ^b   Kansas, Geoffrey S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FUCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE; INTERLEUKIN 12; LIGAND; N ACETYLGLUCOSAMINYLTRANSFERASE; PADGEM PROTEIN; RETROVIRUS VECTOR; SIALYLTRANSFERASE; STAT4 PROTEIN; TRANSCRIPTION FACTOR T BET;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; ENZYME ANALYSIS; EXAMINATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MEDICAL DOCUMENTATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TH1 CELL; UPREGULATION; VIRAL GENE THERAPY; WILD TYPE;

EID: 28444433752     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-03-0984     Document Type: Article

References (32)

1. Ley K, Kansas GS. Selectins in T cell recruitment to non-lymphoid tissues and sites of inflammation. Nat Rev Immunol. 2004;4:325-335.
2. Austrup F, Vestweber D, Borges E, et al. P- and E-selectin mediate recruitment of T helper 1 but not T helper 2 cells into inflamed tissues. Nature. 1997;385:81-83.
3. Wagers AJ, Waters CM, Stoolman LM, Kansas GS. IL-12 and IL-4 control T cell adhesion to endothelial selectins through opposite effects on FucT-VII gene expression. J Exp Med. 1998;188:2225-2231.
4. van Wely CA, Blanchard AD, Britten CJ. Differential expression of alpha3 fucosyltransferases in Th1 and Th2 cells correlates with their ability to bind P-selectin. Biochem Biophys Res Comm. 1998;18:307-311.
5. Knibbs RN, Craig RA, Maly P, et al. α1,3-fucosyltransferase VII dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts. J Immunol. 1998;161:6305-6315.
6. Maly P, Thall AD, Petryniak B, et al. The α(1,3) fucosyltransferase FucT-VII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell. 1996;86:643-653.
7. Barry SM, Zisoulis DG, Neal JW, Clipstone NA, Kansas GS. Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells. Blood. 2003;102:1771-1778.
8. Zisoulis DG, Kansas GS. H-Ras and PI3K cooperate to induce FucT-VII expression in Jurkat T cells. J Biol Chem. 2004;279:39495-39505.
9. White SJ, Underhill GH, Kaplan MH, Kansas GS. Cutting Edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells. J Immunol. 2001;167:628-631.
10. Ellies LG, Tsuboi S, Petryniak B, Lowe JB, Fukuda M, Marth JD. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity. 1998;9:881-890.
11. Snapp KR, Heitzig CE, Ellies LG, Marth JD, Kansas GS. Differential requirements for the O-linked branching enzyme core 2 β1-6-N- glucosaminyltransferase (C2GlcNAcT-I) in biosynthesis of ligands for E-selectin and P-selectin. Blood. 2001;97:3806-3812.
12. Sperandio M, Thatte A, Foy D, Ellies LG, Marth JD, Ley K. Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase- deficient mice. Blood. 2001;97:3812-3819.
13. Kumar R, Camphausen RT, Sullivan FX, Cumming DA. Core 2 β-1,6-N-Acetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin. Blood. 1996;88:3872-3879.
14. Ouyang Y-B, Lane WS, Moore KL. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. Proc Natl Acad Sci U S A. 1998;95:2896-2901.
15. Ouyang Y-B, Moore KL. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. J Biol Chem. 1998;273:24770-24774.
16. Moore KL. The biology and enzymology of protein tyrosine O-sulfation. J Biol Chem. 2003;278:24243-24246.
17. Ellies LG, Sperandio M, Underhill GH, et al. Sialyltransferase specificity in selectin ligand formation. Blood. 2002;100:3618-3625.
18. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100:655-669.
19. Szabo SJ, Sullivan BM, Stemman C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in Th1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002;295:338-342.
20. Mullen AC, High FA, Hutchins AS, et al. Role of T-bet in commitment of Th1 cells before IL-12-dependent selection. Science. 2001;292:1907-1910.
21. Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 1996;382:174-177.
22. Underhill GH, Minges Wols HA, Fornek JL, Witte PL, Kansas GS. IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Blood. 2002;99:2905-2912.
23. Underhill GH, George D, Bremer EG, Kansas GS. Gene expression profiling reveals a highly specialized genetic program of plasma cells. Blood. 2003;101:4013-4021.
24. + T cells. Nat Immunol. 2002;3:549-557.
25. Kono M, Takashima S, Liu H, et al. Molecular cloning and functional expression of a fifth type alpha 2,3-sialytransferase (mST3Gal V:GM3 synthase). Biochem Biophys Res Comm. 1998;253:170-175.
26. Yamashita T, Hashiramoto A, Haluzik M, et al. Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A. 2003;100:3445-3449.
27. Okajima T, Fukumoto S, Miyazaki H, et al. Molecular cloning of a novel alpha 2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. J Biol Chem. 1999;274:11479-11486.
28. Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not Stat1, prevents the development of experimental autoimmune encephalitis. J Exp Med. 2004;200:79-87.
29. Juedes AE, Rodrigo E, Togher L, Glimcher LH, von Herrath MG. T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J Exp Med. 2004;199:1153-1162.
30. Neurath MF, Weigmann B, Finotto S, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med. 2002;195:1129-1143.
31. Smithson G, Rogers CE, Smith PL, et al. FucTVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with FucT-IV, regulates naive T cell trafficking to lymph nodes. J Exp Med. 2001;194:601-614.
32. Lord GM, Rao RM, Choe H, et al. T-bet is required for optimal pro-inflammatory CD4 T cell trafficking. Blood. Prepublished on July 12, 2005, as DOI 10.1182/blood-2005-04-1393.