Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease

Journal of Medicinal Chemistry

Volumn 49, Issue 17, 2006, Pages 5154-5161

  Lu, I Lin ^a,b   Mahindroo, Neeraj ^b   Liang, Po Huang ^c   Peng, Yi Hui ^d   Kuo, Chih Jung ^c   Tsai, Keng Chang ^b   Hsieh, Hsing Pang ^b   Chao, Yu Sheng ^b   Wu, Su Ying ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[[3 (4 CHLOROPHENYL) 1,2,4 OXADIAZOL 5 YL]METHYL]THIO] 4,5 DIHYDRO 1H IMIDAZOL 3 IUM CHLORIDE; 6 METHOXY 3 NITRO 2 (PHENYLSULFONYL)PYRIDINE; CINANSERIN; CYSTEINE; ETACRYNIC ACID; HISTIDINE; ISATIN DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; COVALENT BOND; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; IC 50; LIFE CYCLE; NONHUMAN; PROTEIN CONFORMATION; SARS CORONAVIRUS; VIROGENESIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; DATABASES, FACTUAL; DRUG DESIGN; HYDROGEN BONDING; IMIDAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXADIAZOLES; PROTEASE INHIBITORS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; SARS VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; VIRAL PROTEINS;

EID: 33747458480     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060207o     Document Type: Article

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