From genome to drug lead: Identification of a small-molecule inhibitor of the SARS virus

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 4, 2006, Pages 830-833

  Dooley, Andrea J ^a   Shindo, Nice ^b   Taggart, Barbara ^b   Park, Jewn Giew ^a   Pang, Yuan Ping ^a  

^a MAYO CLINIC   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Anti SARS agents; Antiviral agents; Chemical databases; Docking; Drug lead identification; In silico screening; Small molecule inhibitor leads

Indexed keywords

CYSTEINE PROTEINASE; ENZYME INHIBITOR;

ARTICLE; AVIAN INFLUENZA; CELL ASSAY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; GENOME; GENOMICS; INFECTION; NONHUMAN; SARS CORONAVIRUS; SCREENING;

AMINOBENZOIC ACIDS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SARS VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP;

AVES; CORONAVIRUS; SARS CORONAVIRUS;

EID: 30344480804     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.018     Document Type: Article

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