Structure-activity relationship studies: Methods and ligand design for G-protein coupled peptide receptors

Current Protein and Peptide Science

Volumn 7, Issue 4, 2006, Pages 335-353

  Lang, Manja ^a   Beck Sickinger, Annette G ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Ca binding proteins; Growth hormone secretagogue receptor (GHS R); Receptor conformation; Second messenger; Signal transduction

Indexed keywords

3 AMINO 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; BIBN 4096; CALCITONIN GENE RELATED PEPTIDE; CALCIUM; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR; IBUTAMOREN; INOSITOL 1,4,5 TRISPHOSPHATE; LIGAND; NEW DRUG; OLCEGEPANT; OREXIN; RADIOLIGAND;

BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CELL ACTIVITY; CELL MEMBRANE; CYCLIZATION; DISEASE SEVERITY; DOWNSTREAM PROCESSING; DRUG DESIGN; DRUG RECEPTOR BINDING; FLUOROMETRY; HUMAN; IC 50; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MODIFICATION; RADIOASSAY; RECEPTOR BINDING; REVIEW; SEPARATION TECHNIQUE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; VALIDATION PROCESS;

AMINO ACID SEQUENCE; ANIMALS; DRUG DESIGN; GROWTH HORMONE; HUMANS; KINETICS; LIGANDS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN ENGINEERING; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747245071     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920306778017981     Document Type: Review

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