Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues

Biochemical and Biophysical Research Communications

Volumn 284, Issue 3, 2001, Pages 655-659

  Matsumoto, Masaru ^a   Kitajima, Yasuo ^a   Iwanami, Tatsuya ^a   Hayashi, Yujiro ^a   Tanaka, Shoji ^a   Minamitake, Yoshiharu ^a   Hosoda, Hiroshi ^b   Kojima, Masayasu ^b   Matsuo, Hisayuki ^b   Kangawa, Kenji ^b  

^a SUNTORY LTD   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Ghrelin; Growth hormone secretagogues (GHS's); Ipamorelin; n octanoyl; Structure activity

Indexed keywords

GHRELIN DERIVATIVE; GROWTH HORMONE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; GEOMETRY; GROWTH HORMONE RELEASE; HORMONE STRUCTURE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION;

EID: 0034817074     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5014     Document Type: Article

References (12)

1. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
2. GH releasing peptides - Structure and kinetics
3. GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats
4. Design and biological activities of L-163,191 (MK-0677): A potent, orally active growth hormone secretagogue
5. Ipamorelin, the first selective growth hormone secretagogue
6. Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential
7. A receptor in pituitary and hypothalamus that functions in growth hormone release
8. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
9. Structure-activity relationship of ghrelin: Pharmacological study of mammalian ghrelin peptide and its derivatives
10. Structure-activity relationships of ghrelin - Endogenous growth hormone secretagogue
11. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
12. Polymer-bound oxime esters as supports for solid-phase peptide synthesis. Preparation of protected peptide fragments