Pseudoprolines (ΨPro) in drug design: Direct insertion of ΨPro systems into cyclosporin C

Chemistry - A European Journal

Volumn 6, Issue 23, 2000, Pages 4358-4363

  Keller, Michael ^a   Wöhr, Torsten ^a   Dumy, Pascal ^a   Patiny, Luc ^a   Mutter, Manfred ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Amirno acids; Cyclosporin derivatives; Drug research; Isomerases; Peptides; Pseudoprolines

Indexed keywords

ACETAL DERIVATIVE; CYCLOPHILIN A; CYCLOSPORIN C; HYDROXYL GROUP; ISOMERASE; NITROGEN; OXAZOLIDINE DERIVATIVE; PEPTIDE; PROLINE DERIVATIVE; CYCLOSPORIN DERIVATIVE; DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; IMMUNOSUPPRESSIVE AGENT; PROLINE;

ARTICLE; DRUG DESIGN; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; ENZYMOLOGY; SYNTHESIS; THYMUS;

ANIMALS; CATTLE; CYCLOPHILIN A; CYCLOSPORINS; DRUG DESIGN; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROLINE; THYMUS GLAND;

EID: 0034405086     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3765(20001201)6:23<4358::AID-CHEM4358>3.0.CO;2-W     Document Type: Article

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