Immortalized fibroblasts from NF-κB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor α after transformation by v-Ras

Oncogene

Volumn 24, Issue 43, 2005, Pages 6574-6583

  Gapuzan, Maria Emily R ^a   Schmah, Oliver ^b   Pollock, Ashley D ^a   Hoffmann, Alexander ^b   Gilmore, Thomas D ^a  

^a Boston University   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Malignant transformation; Mouse knockout cells; NF B; Ras; RelA; Tumor necrosis factor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; PROTEIN P53; RAS PROTEIN; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

AGAR MEDIUM; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL IMMORTALIZATION; CELL STRAIN 3T3; CELL STRUCTURE; CELL TYPE; COLONY FORMING CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FIBROBLAST CULTURE; GENE REPRESSION; GENETIC HETEROGENEITY; INDUCED MUTATION; KNOCKOUT MOUSE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE RAS; PHASE TRANSITION; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INDUCTION; PROTEIN TARGETING; RETROVIRUS; VIRUS CARCINOGENESIS; ANIMAL; BINDING SITE; CELL LINE; CELL TRANSFORMATION; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; FIBROBLAST; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHENOTYPE; PROTO ONCOGENE;

ALPHAVIRUS; ANIMALIA;

ANIMALS; BINDING SITES; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GENES, RAS; GENES, REL; MICE; MICE, KNOCKOUT; NF-KAPPA B; PHENOTYPE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 26944478633     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208809     Document Type: Article

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