Neuroscience: Genetic tracing shows segregation of taste neuronal circuitries for bitter and sweet

Science

Volumn 309, Issue 5735, 2005, Pages 781-785

  Sugita, Makoto ^a   Shiba, Yoshiki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; GENETIC ENGINEERING; LIVING SYSTEMS STUDIES; SENSORY PERCEPTION;

GENETIC TRACING; NEURONAL BASES; NEURONAL CIRCUITRIES; TASTE RECEPTORS;

NEUROLOGY;

TRACER; G PROTEIN COUPLED RECEPTOR; HYBRID PROTEIN; T1R RECEPTOR; T2R TASTE RECEPTORS; WHEAT GERM AGGLUTININ;

GENETIC ANALYSIS; TASTE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BITTER TASTE; BRAIN; CONTROLLED STUDY; EMBRYO; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MOUSE; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWEETNESS; SYNAPSE; TASTE; TASTE BUD; TASTE DISCRIMINATION; ANIMAL; BRAIN MAPPING; CELL LINE; CELL STRAIN COS1; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METABOLISM; NERVE CELL; NERVE TRACT; PHYSIOLOGY; PROMOTER REGION; TRANSGENIC MOUSE;

ANIMALIA; MAMMALIA;

ANIMALS; BRAIN; BRAIN MAPPING; CELL LINE; COS CELLS; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; NEURAL PATHWAYS; NEURONS; PROMOTER REGIONS (GENETICS); RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; TASTE; TASTE BUDS; TRANSFECTION; WHEAT GERM AGGLUTININS;

EID: 23044469366     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1110787     Document Type: Article

References (22)

1. B. Lindemann, Nature 413, 219 (2001).
2. D. E. Berman, Y. Dudai, Science 291, 2417 (2001).
3. H. Matsunami, J. P. Montmayeur, L. B. Buck, Nature 404, 601 (2000).
4. E. Adler et al., Cell 100, 693 (2000).
5. J. Chandrashekar et al., Cell 100, 703 (2000).
6. G. Nelson et al., Cell 106, 381 (2001).
7. G. Nelson et al., Nature 416, 199 (2002).
8. Y. Zhang et al., Cell 112, 293 (2003).
9. G. Q. Zhao et al., Cell 115, 255 (2003).
10. K. L. Mueller et al., Nature 434, 225 (2005).
11. R. Norgren, in The Rat Nervous System, G. Paxinos, Ed. (Academic Press, San Diego, 1995), pp. 751-771.
12. H. Herbert, M. M. Moga, C. B. Saper, J. Comp. Neurol. 293, 540 (1990).
13. J. F. Bernard, M. Alden, J. M. Besson, J. Comp. Neurol. 329, 201 (1993).
14. H. Bester, L. Bourgeais, L. Villanueva, J. M. Besson, J. F. Bernard, J. Comp. Neurol. 405, 421 (1999).
15. Y. Yoshihara et al., Neuron 22, 33 (1999).
16. Z. Zou, L. F. Horowitz, J.-P. Montmayeur, S. Snapper, L. B. Buck, Nature 414, 173 (2001).
17. M. Sugita, unpublished results.
18. R. B. Hamilton, R. Norgren, J. Comp. Neurol. 222, 560 (1984).
19. R. Norgren, J. Comp. Neurol. 166, 17 (1976).
20. G. V. Allen, C. B. Saper, K. M. Hurley, D. F. Cechetto, J. Comp. Neurol. 311, 1 (1991).
21. C. L. Yee, K. R. Jones, T. E. Finger, J. Comp. Neurol. 459, 15 (2003).
22. We are grateful to the members in Research Facilities for Laboratory Animal Science, Natural Science Center for Basic Research and Development, Hiroshima University, for supporting animal experiment. We thank H. Ohishi for expert help in calcium imaging, Y. Yoshihara for truncated WGA, S. Offermanns and M. I. Simon for Gα 15, and P. Mombaerts for ETLpA-/LTNL. This research was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan, and the Sumitomo Foundation (to M.S.).