Phosphodiesterases in the CNS: Targets for drug development

Nature Reviews Drug Discovery

Volumn 5, Issue 8, 2006, Pages 660-670

  Menniti, Frank S ^a   Faraci, W Stephen ^a   Schmidt, Christopher J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 (2 HYDROXY 3 NONYL)ADENINE; BAY 60 7550; BAY 73 6691; CILOSTAMIDE; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; ENZYME INHIBITOR; GUANINE DERIVATIVE; IC 224; MESSENGER RNA; MILRINONE; PAPAVERINE; PHOSPHODIESTERASE IB INHIBITOR; PHOSPHODIESTERASE II INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE IX INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VII INHIBITOR; PHOSPHODIESTERASE VIIIA INHIBITOR; PHOSPHODIESTERASE X INHIBITOR; PQ 10; PQ 20; ROLIPRAM; SILDENAFIL; TADALAFIL; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARDENAFIL; VINPOCETINE;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; BINDING AFFINITY; BLOOD BRAIN BARRIER; CELL ACTIVITY; CELL COMPARTMENTALIZATION; CENTRAL NERVOUS SYSTEM; COGNITIVE DEFECT; DEGENERATIVE DISEASE; DEPRESSION; DRUG APPROVAL; DRUG EFFICACY; DRUG INDICATION; DRUG PENETRATION; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TRANSPORT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME SPECIFICITY; ERECTILE DYSFUNCTION; GENE SEQUENCE; GENOME ANALYSIS; HUMAN; HUMAN GENOME; MENTAL DISEASE; NAUSEA AND VOMITING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; PSYCHOSIS; PULMONARY HYPERTENSION; REVIEW; SCHIZOPHRENIA; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; BRAIN DISEASES; DRUG DESIGN; HUMANS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; SIGNAL TRANSDUCTION;

EID: 33746629480     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2058     Document Type: Review

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